A Mendelian randomization study of the entire phenome to explore the causal links between epilepsy

• Published in: Brain and behavior Vol. 14; no. 6; pp. e3602 - n/a
• Main Authors: Zhang, Wei, Zhang, Li‐Ming, Zhi, Lin, Qi, Ji, He, Jue
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.06.2024; John Wiley and Sons Inc; Wiley
• Subjects: Amygdala; biomarker; Biomarkers - blood; Consortia; Convulsions & seizures; Epilepsy; Epilepsy - epidemiology; Epilepsy - genetics; Estimates; Etiology; Genome-Wide Association Study; Genomes; Health care expenditures; Humans; lifestyle; Mendelian randomization; Mendelian Randomization Analysis; Original; phenome; Phenomics; Phenotype; Risk Factors; epilepsy; phenome; Mendelian randomization; biomarker; lifestyle

Objective The causes and triggering factors of epilepsy are still unknown. The results of genome‐wide association studies can be utilized for a phenome‐wide association study using Mendelian randomization (MR) to identify potential risk factors for epilepsy. Methods This study utilizes two‐sample MR...