Interactome analysis of the EV71 5′ untranslated region in differentiated neuronal cells SH-SY5Y and regulatory role of FBP3 in viral replication

• Published in: Proteomics (Weinheim) Vol. 16; no. 17; pp. 2351 - 2362
• Main Authors: Huang, Hsing-I, Chang, Ying-Ying, Lin, Jhao-Yin, Kuo, Rei-Lin, Liu, Hao-Ping, Shih, Shin-Ru, Wu, Chih-Ching
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 01.09.2016; Wiley Subscription Services, Inc
• Subjects: 5' Untranslated Regions; Cell differentiation; Cell Line; Differentiated neuronal cells; DNA-Binding Proteins - metabolism; Enterovirus; Enterovirus A, Human - genetics; Enterovirus A, Human - physiology; Enterovirus Infections - metabolism; Enterovirus Infections - pathology; EV71; FBP3; Humans; Internal ribosomal entry site; Microbiology; Neurons - metabolism; Neurons - pathology; Neurons - virology; Protein folding; Proteins; RNA, Viral - genetics; RNA, Viral - metabolism; Transcription Factors - metabolism; Virus Replication; Differentiated neuronal cells; Internal ribosomal entry site; EV71; Microbiology; FBP3

Enterovirus 71 (EV71), a single‐stranded RNA virus, is one of the most serious neurotropic pathogens in the Asia‐Pacific region. Through interactions with host proteins, the 5′ untranslated region (5′UTR) of EV71 is important for viral replication. To gain a protein profile that interact with the EV...