Intervertebral disc degeneration and how it leads to low back pain

• Published in: JOR-spine Vol. 6; no. 1; pp. e1231 - n/a
• Main Authors: Diwan, Ashish D., Melrose, James
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2023; Wiley
• Subjects: artificial intelligence; Back pain; Cartilage; Chronic pain; Cytokines; Degenerative disc disease; discogenic pain; facial recognition; Flexibility; GDF6; intervertebral disc degeneration; Ligaments; low back pain; Muscle pain; neuropathic pain; nociceptive pain; Population; Review; Reviews; Spinal cord; intervertebral disc degeneration; neuropathic pain; nociceptive pain; low back pain; facial recognition; GDF6; artificial intelligence; discogenic pain

The purpose of this review was to evaluate data generated by animal models of intervertebral disc (IVD) degeneration published in the last decade and show how this has made invaluable contributions to the identification of molecular events occurring in and contributing to pain generation. IVD degene...