Characters of KRT80 and its roles in neoplasms diseases

• Published in: Cancer medicine (Malden, MA) Vol. 12; no. 13; pp. 13991 - 14003
• Main Authors: Wei, Xin‐Yuan, Zhao, Jie, Tong, Hao‐Bin, Cheng, Shang‐Jie, He, Na, Song, Fei‐Xue
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.07.2023; John Wiley and Sons Inc; Wiley
• Subjects: Apoptosis; Cancer; cancers; Cell migration; Cell proliferation; Chromosomes; Cytoskeleton; Cytoskeleton - metabolism; Epithelial cells; Epithelial Cells - metabolism; Esophageal cancer; Filaments; Genes; Hair; Humans; Intermediate filaments; Invasiveness; Keratin; Keratins - genetics; Keratins - metabolism; KRT80; mechanism; neoplasms; Neoplasms - genetics; Neoplasms - metabolism; Prognosis; Proteins; Review; REVIEWS; Roles; Therapeutic applications; Therapeutic targets; Tumors; cancers; keratin; KRT80; mechanism; neoplasms; intermediate filaments
• ISSN: 2045-7634; 2045-7634
• DOI: 10.1002/cam4.6040

Background KRT80 is a human epithelial intermediate filament type II gene; its expression product is a component of intracellular intermediate filaments (IFs) and is involved in the assembly of the cytoskeleton. There is evidence that IFs form a dense network mainly in the perinuclear area, but they can also reach the cortex. They are essential for mechanical cushioning of cells, organelle positioning, cell apoptosis, migration, adhesion, and interactions with other cytoskeletal components. Humans possess 54 functional keratin genes, and KRT80 is one of the more unique genes. It is widely expressed in almost all epithelial cells, although it is structurally more similar to type II hair keratins than to type II epithelial keratins. Aim In this review, we summarize the basic facts about the keratin family and KRT80, the essential role of KRT80 in neoplasms, and its potential as a therapeutic target. We hope that this review will inspire researchers to at least partially focus on this area. Result In many neoplastic diseases, the high expression status of KRT80 and its role in regulating the biological functions of cancer cells have been well established. KRT80 can effectively enhance the proliferation, invasiveness and migration of cancer cells. However, the effects of KRT80 on prognosis and clinically relevant indices in patients with various cancers have not been extensively studied, and even opposite conclusions have been reached in different studies of the same cancer. Based on this, we should add more clinically relevant studies to clarify the prospect of clinical application of KRT80. Many researchers have made great progress in studying the mechanism of action of KRT80. However, their studies should be extended to more cancers to find common regulators and signaling pathways of KRT80 in different cancers. KRT80 may have far‐reaching effects on the human body, and this marker may play a crucial role in the function of cancer cells and the prognosis of cancer patients, so it has a promising future in the field of neoplasms. Conclusion In neoplastic diseases, KRT80 is overexpressed in many cancers and plays an essential role in promoting proliferation, migration, invasiveness and poor prognosis. The mechanisms of KRT80 functions in cancer have been partially elucidated, suggesting that KRT80 is a potentially useful cancer therapeutic target. However, more systematic, in‐depth and comprehensive studies are still needed in this field.