Protective role of mirtazapine in adult female Mecp2+/− mice and patients with Rett syndrome

• Published in: Journal of neurodevelopmental disorders Vol. 12; no. 1; pp. 26 - 20
• Main Authors: Flores Gutiérrez, Javier, De Felice, Claudio, Natali, Giulia, Leoncini, Silvia, Signorini, Cinzia, Hayek, Joussef, Tongiorgi, Enrico
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 28.09.2020; BioMed Central; BMC
• Subjects: Age; Amygdala; Analysis; Animals; Antidepressants; Behavior; Biopsy; Cortex (barrel); Cortex (motor); Deoxyribonucleic acid; DNA; Ethanol; Females; Gene mutation; Genetic aspects; Genotype & phenotype; Hypersensitivity; Intellectual disabilities; Intellectual disability disorders; Irritability/aggressiveness; Laboratories; MeCP2 protein; Methyl-CpG binding protein; Mirtazapine; Mood; Motor learning deficits; Motor skill; Motor skill learning; Mutation; Neurodevelopmental disorders; Norepinephrine; Parvalbumin; Patients; Phenotypes; Rare diseases; Rett syndrome; Rodents; Sleep disorders; Social aspects; Social behavior; Somatosensory cortex; United States > US; Intellectual disability disorders; Somatosensory cortex; Irritability/aggressiveness; Parvalbumin neurons; Motor learning deficits; Antidepressants; Rett syndrome

Rett syndrome (RTT), an X-linked neurodevelopmental rare disease mainly caused by MECP2-gene mutations, is a prototypic intellectual disability disorder. Reversibility of RTT-like phenotypes in an adult mouse model lacking the Mecp2-gene has given hope of treating the disease at any age. However, ad...