Closed-loop control of targeted ultrasound drug delivery across the blood–brain/tumor barriers in a rat glioma model

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 48; pp. E10281 - E10290
• Main Authors: Sun, Tao, Zhang, Yongzhi, Power, Chanikarn, Alexander, Phillip M., Sutton, Jonathan T., Aryal, Muna, Vykhodtseva, Natalia, Miller, Eric L., McDannold, Nathan J.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 28.11.2017
• Series: PNAS Plus
• Subjects: Biological Sciences; Blood-brain barrier; Cavitation; Physical Sciences; PNAS Plus; Regression analysis; Rodents; Tumors; Ultrasonic imaging; acoustic cavitation; blood–brain barrier; drug delivery; focused ultrasound; treatment control

Cavitation-facilitated microbubble-mediated focused ultrasound therapy is a promising method of drug delivery across the blood–brain barrier (BBB) for treating many neurological disorders. Unlike ultrasound thermal therapies, during which magnetic resonance thermometry can serve as a reliable treatm...