Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply - Shao, Xuan; Cao, Guangming; Chen, Dunjin; Liu, Juan; Yu, Bolan; Liu, Ming; Li, Yu-Xia; Cao, Bin; Sadovsky, Yoel; Wang, Yan-Ling (Proceedings of the National Academy of Sciences - PNAS, 2021)
Keywords: Adaptation, Physiological; Amino acids; Amino Acids - deficiency; AMP-Activated Protein Kinases - genetics; AMP-Activated Protein Kinases - metabolism; Animals; Biological Sciences; Cell differentiation; Cell Line; Cell lines; Cell Nucleus - genetics; Cell Nucleus - metabolism; Cellular structure; Chorionic Villi - metabolism; Deprivation; Female; Fetal Growth Retardation - genetics; Fetal Growth Retardation - metabolism; Fetal Growth Retardation - pathology; Fetuses; Gene Expression Regulation; Humans; Maternal-Fetal Exchange - physiology; Mice; Nutrient status; Nutrients; Phenotypes; Pinocytosis - genetics; Placenta; Pregnancy; Pregnancy Proteins - genetics; Pregnancy Proteins - metabolism; Primary Cell Culture; Rapamycin; Ribosomal Protein S6 Kinases, 70-kDa - genetics; Ribosomal Protein S6 Kinases, 70-kDa - metabolism; Signal Transduction; Signaling; Sirolimus - pharmacology; TOR protein; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Trophoblasts; Trophoblasts - cytology; Trophoblasts - metabolism; mTOR; macropinocytosis; fetal growth; placental syncytiotrophoblast; amino acid shortage