Carbamazepine-Induced Toxic Effects and HLA-B1502 Screening in Taiwan

• Published in: The New England journal of medicine Vol. 364; no. 12; pp. 1126 - 1133
• Main Authors: Chen, Pei, Chen, Chien-Hsiun, Chen, Ying-Ju, Chen, Yuan-Tsong, Chen, Luke, Lin, Shu-Yi, Lin, Juei-Jueng, Lin, Yu-Hsuan, Lu, Chung-Ta, Lu, Chin-Song, Lu, Cheng-Hsien, Ong, Cheung-Ter, Hsieh, Peiyuan F, Yang, Chih-Chao, Tai, Chih-Ta, Wu, Jer-Yuarn, Wu, Shey-Lin, Hsu, Yung-Chu, Yu, Hsiang-Yu, Ro, Long-Sun, Chu, Chun-Che, Tsai, Pei-Joung, Tsai, Jing-Jane, Su, Yu-Hsiang, Lan, Sheng-Hsing, Sung, Sheng-Feng, Chuang, Hui-Ping, Huang, Li-Chen, Liao, Hung-Ting, Chung, Wen-Hung, Hung, Shuen-Iu, Chang, Chi-Feng, Shen, Chen-Yang
• Format: Journal Article
• Language: English
• Published: Waltham, MA Massachusetts Medical Society 24.03.2011
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anticonvulsants - adverse effects; Anticonvulsants - therapeutic use; Anticonvulsants. Antiepileptics. Antiparkinson agents; Apoptosis; Asian Continental Ancestry Group - genetics; Biological and medical sciences; Carbamazepine - adverse effects; Carbamazepine - therapeutic use; Child; Child, Preschool; Clinical medicine; Confidence intervals; Drug-Related Side Effects and Adverse Reactions - genetics; Drug-Related Side Effects and Adverse Reactions - prevention & control; Female; General aspects; Genetic Testing; Genotype; HLA-B Antigens - genetics; HLA-B15 Antigen; Humans; Incidence; Infant; Male; Medical research; Medical sciences; Middle Aged; Neuropharmacology; Pharmacogenetics; Pharmacology. Drug treatments; Prevention and actions; Public health. Hygiene; Public health. Hygiene-occupational medicine; Stevens-Johnson Syndrome - chemically induced; Stevens-Johnson Syndrome - epidemiology; Stevens-Johnson Syndrome - genetics; Stevens-Johnson Syndrome - prevention & control; Taiwan; Young Adult; Asia; Taiwan; HLA-System; Toxicity; Major histocompatibility system; Anticonvulsant; Tricyclic compound; Medical screening; Carbamazepine; Medicine; Mood stabilizer; Carboxamide; Dibenzazepine derivatives; Class I histocompatibility antigen; HLA-B-Locus

In this prospective study, Han Chinese subjects who were candidates for carbamazepine therapy were screened for the HLA-B*1502 allele because of its association with the Stevens–Johnson syndrome and toxic epidermal necrolysis. The Stevens–Johnson syndrome (SJS) and its related disease, toxic epiderm...