Carbamazepine-Induced Toxic Effects and HLA-B1502 Screening in Taiwan
In this prospective study, Han Chinese subjects who were candidates for carbamazepine therapy were screened for the HLA-B*1502 allele because of its association with the Stevens–Johnson syndrome and toxic epidermal necrolysis. The Stevens–Johnson syndrome (SJS) and its related disease, toxic epiderm...
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| Published in | The New England journal of medicine Vol. 364; no. 12; pp. 1126 - 1133 |
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| Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Waltham, MA
Massachusetts Medical Society
24.03.2011
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| Subjects | |
| Online Access | Get full text |
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| Abstract | In this prospective study, Han Chinese subjects who were candidates for carbamazepine therapy were screened for the HLA-B*1502 allele because of its association with the Stevens–Johnson syndrome and toxic epidermal necrolysis.
The Stevens–Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), are two of the most serious adverse reactions caused by drugs. SJS is characterized by high fever, malaise, and a rapidly developing, blistering exanthema of macular papules and target-like lesions, accompanied by mucosal involvement. This condition is associated with a rate of death of approximately 5%. TEN has a similar presentation, with even more extensive skin detachment and a death rate of 25 to 35%.
1
Carbamazepine, an anticonvulsant and specific analgesic agent for trigeminal neuralgia, is the most common cause of SJS–TEN in Southeast Asian countries.
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We previously . . . |
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| AbstractList | In this prospective study, Han Chinese subjects who were candidates for carbamazepine therapy were screened for the HLA-B*1502 allele because of its association with the Stevens–Johnson syndrome and toxic epidermal necrolysis.
The Stevens–Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), are two of the most serious adverse reactions caused by drugs. SJS is characterized by high fever, malaise, and a rapidly developing, blistering exanthema of macular papules and target-like lesions, accompanied by mucosal involvement. This condition is associated with a rate of death of approximately 5%. TEN has a similar presentation, with even more extensive skin detachment and a death rate of 25 to 35%.
1
Carbamazepine, an anticonvulsant and specific analgesic agent for trigeminal neuralgia, is the most common cause of SJS–TEN in Southeast Asian countries.
2
We previously . . . Carbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main cause of the Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), in Southeast Asian countries. Carbamazepine-induced SJS-TEN is strongly associated with the HLA-B*1502 allele. We sought to prevent carbamazepine-induced SJS-TEN by using HLA-B*1502 screening to prospectively identify subjects at genetic risk for the condition. From 23 hospitals in Taiwan, we recruited 4877 candidate subjects who had not taken carbamazepine. We genotyped DNA purified from the subjects' peripheral blood to determine whether they carried the HLA-B*1502 allele. Those testing positive for HLA-B*1502 (7.7% of the total) were advised not to take carbamazepine and were given an alternative medication or advised to continue taking their prestudy medication; those testing negative (92.3%) were advised to take carbamazepine. We interviewed the subjects by telephone once a week for 2 months to monitor them for symptoms. We used the estimated historical incidence of SJS-TEN as a control. Mild, transient rash developed in 4.3% of subjects; more widespread rash developed in 0.1% of subjects, who were hospitalized. SJS-TEN did not develop in any of the HLA-B*1502-negative subjects receiving carbamazepine. In contrast, the estimated historical incidence of carbamazepine-induced SJS-TEN (0.23%) would translate into approximately 10 cases among study subjects (P<0.001). The identification of subjects carrying the HLA-B*1502 allele and the avoidance of carbamazepine therapy in these subjects was strongly associated with a decrease in the incidence of carbamazepine-induced SJS-TEN. (Funded by the National Science Council of Taiwan and the Taiwan Drug Relief Foundation.). Carbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main cause of the Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), in Southeast Asian countries. Carbamazepine-induced SJS-TEN is strongly associated with the HLA-B*1502 allele. We sought to prevent carbamazepine-induced SJS-TEN by using HLA-B*1502 screening to prospectively identify subjects at genetic risk for the condition.BACKGROUNDCarbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main cause of the Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), in Southeast Asian countries. Carbamazepine-induced SJS-TEN is strongly associated with the HLA-B*1502 allele. We sought to prevent carbamazepine-induced SJS-TEN by using HLA-B*1502 screening to prospectively identify subjects at genetic risk for the condition.From 23 hospitals in Taiwan, we recruited 4877 candidate subjects who had not taken carbamazepine. We genotyped DNA purified from the subjects' peripheral blood to determine whether they carried the HLA-B*1502 allele. Those testing positive for HLA-B*1502 (7.7% of the total) were advised not to take carbamazepine and were given an alternative medication or advised to continue taking their prestudy medication; those testing negative (92.3%) were advised to take carbamazepine. We interviewed the subjects by telephone once a week for 2 months to monitor them for symptoms. We used the estimated historical incidence of SJS-TEN as a control.METHODSFrom 23 hospitals in Taiwan, we recruited 4877 candidate subjects who had not taken carbamazepine. We genotyped DNA purified from the subjects' peripheral blood to determine whether they carried the HLA-B*1502 allele. Those testing positive for HLA-B*1502 (7.7% of the total) were advised not to take carbamazepine and were given an alternative medication or advised to continue taking their prestudy medication; those testing negative (92.3%) were advised to take carbamazepine. We interviewed the subjects by telephone once a week for 2 months to monitor them for symptoms. We used the estimated historical incidence of SJS-TEN as a control.Mild, transient rash developed in 4.3% of subjects; more widespread rash developed in 0.1% of subjects, who were hospitalized. SJS-TEN did not develop in any of the HLA-B*1502-negative subjects receiving carbamazepine. In contrast, the estimated historical incidence of carbamazepine-induced SJS-TEN (0.23%) would translate into approximately 10 cases among study subjects (P<0.001).RESULTSMild, transient rash developed in 4.3% of subjects; more widespread rash developed in 0.1% of subjects, who were hospitalized. SJS-TEN did not develop in any of the HLA-B*1502-negative subjects receiving carbamazepine. In contrast, the estimated historical incidence of carbamazepine-induced SJS-TEN (0.23%) would translate into approximately 10 cases among study subjects (P<0.001).The identification of subjects carrying the HLA-B*1502 allele and the avoidance of carbamazepine therapy in these subjects was strongly associated with a decrease in the incidence of carbamazepine-induced SJS-TEN. (Funded by the National Science Council of Taiwan and the Taiwan Drug Relief Foundation.).CONCLUSIONSThe identification of subjects carrying the HLA-B*1502 allele and the avoidance of carbamazepine therapy in these subjects was strongly associated with a decrease in the incidence of carbamazepine-induced SJS-TEN. (Funded by the National Science Council of Taiwan and the Taiwan Drug Relief Foundation.). Background Carbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main cause of the Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal necrolysis (TEN), in Southeast Asian countries. Carbamazepine-induced SJS-TEN is strongly associated with the HLA-B*1502 allele. We sought to prevent carbamazepine-induced SJS-TEN by using HLA-B*1502 screening to prospectively identify subjects at genetic risk for the condition. Methods From 23 hospitals in Taiwan, we recruited 4877 candidate subjects who had not taken carbamazepine. We genotyped DNA purified from the subjects' peripheral blood to determine whether they carried the HLA-B*1502 allele. Those testing positive for HLA-B*1502 (7.7% of the total) were advised not to take carbamazepine and were given an alternative medication or advised to continue taking their prestudy medication; those testing negative (92.3%) were advised to take carbamazepine. We interviewed the subjects by telephone once a week for 2 months to monitor them for symptoms. We used the estimated historical incidence of SJS-TEN as a control. Results Mild, transient rash developed in 4.3% of subjects; more widespread rash developed in 0.1% of subjects, who were hospitalized. SJS-TEN did not develop in any of the HLA-B*1502-negative subjects receiving carbamazepine. In contrast, the estimated historical incidence of carbamazepine-induced SJS-TEN (0.23%) would translate into approximately 10 cases among study subjects (P<0.001). Conclusions The identification of subjects carrying the HLA-B*1502 allele and the avoidance of carbamazepine therapy in these subjects was strongly associated with a decrease in the incidence of carbamazepine-induced SJS-TEN. (Funded by the National Science Council of Taiwan and the Taiwan Drug Relief Foundation.) |
| Author | Lu, Chin-Song Su, Yu-Hsiang Lin, Yu-Hsuan Hsu, Yung-Chu Liao, Hung-Ting Lan, Sheng-Hsing Wu, Shey-Lin Chung, Wen-Hung Tai, Chih-Ta Chen, Yuan-Tsong Huang, Li-Chen Hung, Shuen-Iu Chuang, Hui-Ping Tsai, Jing-Jane Wu, Jer-Yuarn Lin, Juei-Jueng Lin, Shu-Yi Chang, Chi-Feng Shen, Chen-Yang Chen, Luke Lu, Chung-Ta Hsieh, Peiyuan F Ro, Long-Sun Tsai, Pei-Joung Yu, Hsiang-Yu Chen, Ying-Ju Lu, Cheng-Hsien Ong, Cheung-Ter Chen, Pei Sung, Sheng-Feng Chen, Chien-Hsiun Yang, Chih-Chao Chu, Chun-Che |
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| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=23976057$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/21428768$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1097/01.fpc.0000199500.46842.4a 10.1111/j.1528-1167.2007.01022.x 10.1001/archderm.136.3.323 10.1038/nm.1884 10.1093/hmg/ddq537 10.2165/00128071-200001060-00003 10.4103/0378-6323.57718 10.1038/sj.tpj.6500356 10.1038/428486a 10.1111/j.1528-1167.2010.02533.x 10.1056/NEJM199411103311906 10.2217/17410541.2.3.225 10.1111/j.1528-1167.2008.01719.x 10.1038/clpt.2009.39 10.1056/NEJMoa1013297 10.1016/j.jaci.2007.06.017 |
| ContentType | Journal Article |
| Contributor | Chang, T Y Ke, D R Hsu, Y T Chang, C A Chien, H U Liu, C S Wu, T C Huang, C C Yu, C M Kao, Y H Chang, C Y Lai, T C Tsai, Y T Chou, C H Huang, C R Chang, W N Chung, W H Huang, K L Chiang, T R Yeh, P S Kuo, Y T Fung, H C Chuang, Y C Hu, C J Lin, J C Shen, J J Yang, Y W Lee, M J Liu, C H Tsai, P C Ruy, S J Tsai, T C Yeh, T H His, M S Kuo, H C Lai, S L Chou, P C Yuan, R Y Lyu, R K Lai, S C Sung, J Y Wu, Y L Chen, Y C Lee, Y Y Wu, Y R Su, J J Wang, H P Lin, K L Chen, R S Tseng, K Y Lin, K P Yip, B S Tsai, C H Lin, K C Hsiao, M C Hong, C J Kuo, H T Lin, K H Wong, T W Kuo, T M Lee, T H Huang, Y Z Sung, C Y Hsieh, M J Chuang, W L Cheng, M Y Chou, I C Yen, D J Wang, K C Hsu, W C Chang, M Y Hsu, C Y Chang, Y J Chuang, C P Liou, C W Weng, Y H Lin, T K Lee, C D Wang, C J Hung, P H Chen, S T Su, M S Yeh, J H Lin, H J Liao, K K Chen, C Chu, N S Wu, C S Hsieh, H Y Chen, C M Wu, C Y Chen, C C Chang, H S Jen, H M Wang, H C Cheng, T J Khor, G T |
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| Copyright | Copyright © 2011 Massachusetts Medical Society. All rights reserved. 2015 INIST-CNRS |
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| Keywords | HLA-System Toxicity Major histocompatibility system Anticonvulsant Tricyclic compound Medical screening Carbamazepine Medicine Mood stabilizer Carboxamide Dibenzazepine derivatives Class I histocompatibility antigen HLA-B-Locus |
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| Snippet | In this prospective study, Han Chinese subjects who were candidates for carbamazepine therapy were screened for the HLA-B*1502 allele because of its... Carbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main cause of the Stevens-Johnson syndrome (SJS) and its related disease, toxic epidermal... Background Carbamazepine, an anticonvulsant and a mood-stabilizing drug, is the main cause of the Stevens-Johnson syndrome (SJS) and its related disease, toxic... |
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| SubjectTerms | Adolescent Adult Aged Aged, 80 and over Anticonvulsants - adverse effects Anticonvulsants - therapeutic use Anticonvulsants. Antiepileptics. Antiparkinson agents Apoptosis Asian Continental Ancestry Group - genetics Biological and medical sciences Carbamazepine - adverse effects Carbamazepine - therapeutic use Child Child, Preschool Clinical medicine Confidence intervals Drug-Related Side Effects and Adverse Reactions - genetics Drug-Related Side Effects and Adverse Reactions - prevention & control Female General aspects Genetic Testing Genotype HLA-B Antigens - genetics HLA-B15 Antigen Humans Incidence Infant Male Medical research Medical sciences Middle Aged Neuropharmacology Pharmacogenetics Pharmacology. Drug treatments Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine Stevens-Johnson Syndrome - chemically induced Stevens-Johnson Syndrome - epidemiology Stevens-Johnson Syndrome - genetics Stevens-Johnson Syndrome - prevention & control Taiwan Young Adult |
| Title | Carbamazepine-Induced Toxic Effects and HLA-B1502 Screening in Taiwan |
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