Antibody-dependent enhancement of severe dengue disease in humans

• Published in: Science (American Association for the Advancement of Science) Vol. 358; no. 6365; pp. 929 - 932
• Main Authors: Katzelnick, Leah C., Gresh, Lionel, Halloran, M. Elizabeth, Mercado, Juan Carlos, Kuan, Guillermina, Gordon, Aubree, Balmaseda, Angel, Harris, Eva
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 17.11.2017; The American Association for the Advancement of Science
• Subjects: Adolescent; Animal diseases; Animal models; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody-Dependent Enhancement; Aquatic insects; Child; Child, Preschool; Children; Cohort Studies; Complications; Dengue - blood; Dengue - immunology; Dengue - virology; Dengue fever; Dengue hemorrhagic fever; Dengue Vaccines - immunology; Disease; Disease transmission; Female; Fever; Humans; Immune response; Male; Pathogenesis; Vaccine development; Vaccines; Vector-borne diseases; Viral diseases; Virology; Viruses

For dengue viruses 1 to 4 (DENV1-4), a specific range of antibody titer has been shown to enhance viral replication in vitro and severe disease in animal models. Although suspected, such antibody-dependent enhancement of severe disease has not been shown to occur in humans. Using multiple statistica...