Association of apolipoprotein E (ApoE) polymorphisms with risk of primary hyperuricemia in Uygur men, Xinjiang, China
Background Apolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between ApoE polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China. Methods A total of 474 hyperuricemia patients and 518 healthy male co...
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| Published in | Lipids in health and disease Vol. 14; no. 1; p. 25 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
London
BioMed Central
12.04.2015
BioMed Central Ltd |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1476-511X 1476-511X |
| DOI | 10.1186/s12944-015-0025-2 |
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| Abstract | Background
Apolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between
ApoE
polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China.
Methods
A total of 474 hyperuricemia patients and 518 healthy male controls were recruited from the Health Screening Center, Uygur region of Xinjiang, China and subjected to ApoE genotyping using a multiplex amplification refractory mutation system PCR.
Results
Apolipoprotein
E3/3
genotype was the predominant type with a frequency of 67.7%, while
E2/2
was lower than
E4/4
in Uygur males. The frequencies of
ApoE2, E3,
and
E4
alleles were 8.5%, 80.1% and 11.4%, respectively. Distribution of ApoE genotypes was significantly different in hyperuricemia patients from the healthy controls (
p <
0.001). Particularly, the frequency of
ApoE E3/3
was 71.7%,
E2/3
9.3%,
E3/4
9.3%,
E4/4
3.2%,
E2/4
2.3%, and
E2/2
0.2% in patients vs. 68.1%, 4.6%, 2.9%, 12%, 0.6%, and 4.6% in controls, respectively. Moreover, frequency of
ApoE
E2 allele was greater in the healthy controls than in patients (
p <
0.001) and the highest level of uric acid occurred in those with
ApoE2/4
and
E3/4
genotypes, whereas the lowest uric acid level occurred in those with
ApoE E2/2
genotype. In addition, the subjects with the ApoE2 allele had a lower uric acid and LDL-C level than those with the ApoE3 allele and ApoE4 allele (p < 0.05). The risk of developing hyperuricemia in subjects without the ApoE2 allele was 1.7 fold higher than those subjects with the ApoE2 allele.
Conclusions
This study revealed frequencies and distributions of
ApoE
alleles and genotypes in Uygur males, which are different from Han Chinese.
ApoE
E4 was associated with a slightly higher risk of primary hyperuricemia, whereas
ApoE
E2 was associated with reduced risk of primary hyperuricemia and LDL-C level. |
|---|---|
| AbstractList | Background
Apolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between
ApoE
polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China.
Methods
A total of 474 hyperuricemia patients and 518 healthy male controls were recruited from the Health Screening Center, Uygur region of Xinjiang, China and subjected to ApoE genotyping using a multiplex amplification refractory mutation system PCR.
Results
Apolipoprotein
E3/3
genotype was the predominant type with a frequency of 67.7%, while
E2/2
was lower than
E4/4
in Uygur males. The frequencies of
ApoE2, E3,
and
E4
alleles were 8.5%, 80.1% and 11.4%, respectively. Distribution of ApoE genotypes was significantly different in hyperuricemia patients from the healthy controls (
p <
0.001). Particularly, the frequency of
ApoE E3/3
was 71.7%,
E2/3
9.3%,
E3/4
9.3%,
E4/4
3.2%,
E2/4
2.3%, and
E2/2
0.2% in patients vs. 68.1%, 4.6%, 2.9%, 12%, 0.6%, and 4.6% in controls, respectively. Moreover, frequency of
ApoE
E2 allele was greater in the healthy controls than in patients (
p <
0.001) and the highest level of uric acid occurred in those with
ApoE2/4
and
E3/4
genotypes, whereas the lowest uric acid level occurred in those with
ApoE E2/2
genotype. In addition, the subjects with the ApoE2 allele had a lower uric acid and LDL-C level than those with the ApoE3 allele and ApoE4 allele (p < 0.05). The risk of developing hyperuricemia in subjects without the ApoE2 allele was 1.7 fold higher than those subjects with the ApoE2 allele.
Conclusions
This study revealed frequencies and distributions of
ApoE
alleles and genotypes in Uygur males, which are different from Han Chinese.
ApoE
E4 was associated with a slightly higher risk of primary hyperuricemia, whereas
ApoE
E2 was associated with reduced risk of primary hyperuricemia and LDL-C level. Apolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between ApoE polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China.BACKGROUNDApolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between ApoE polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China.A total of 474 hyperuricemia patients and 518 healthy male controls were recruited from the Health Screening Center, Uygur region of Xinjiang, China and subjected to ApoE genotyping using a multiplex amplification refractory mutation system PCR.METHODSA total of 474 hyperuricemia patients and 518 healthy male controls were recruited from the Health Screening Center, Uygur region of Xinjiang, China and subjected to ApoE genotyping using a multiplex amplification refractory mutation system PCR.Apolipoprotein E3/3 genotype was the predominant type with a frequency of 67.7%, while E2/2 was lower than E4/4 in Uygur males. The frequencies of ApoE2, E3, and E4 alleles were 8.5%, 80.1% and 11.4%, respectively. Distribution of ApoE genotypes was significantly different in hyperuricemia patients from the healthy controls (p<0.001). Particularly, the frequency of ApoE E3/3 was 71.7%, E2/3 9.3%, E3/4 9.3%, E4/4 3.2%, E2/4 2.3%, and E2/2 0.2% in patients vs. 68.1%, 4.6%, 2.9%, 12%, 0.6%, and 4.6% in controls, respectively. Moreover, frequency of ApoE E2 allele was greater in the healthy controls than in patients (p<0.001) and the highest level of uric acid occurred in those with ApoE2/4 and E3/4 genotypes, whereas the lowest uric acid level occurred in those with ApoE E2/2 genotype. In addition, the subjects with the ApoE2 allele had a lower uric acid and LDL-C level than those with the ApoE3 allele and ApoE4 allele (p<0.05). The risk of developing hyperuricemia in subjects without the ApoE2 allele was 1.7 fold higher than those subjects with the ApoE2 allele.RESULTSApolipoprotein E3/3 genotype was the predominant type with a frequency of 67.7%, while E2/2 was lower than E4/4 in Uygur males. The frequencies of ApoE2, E3, and E4 alleles were 8.5%, 80.1% and 11.4%, respectively. Distribution of ApoE genotypes was significantly different in hyperuricemia patients from the healthy controls (p<0.001). Particularly, the frequency of ApoE E3/3 was 71.7%, E2/3 9.3%, E3/4 9.3%, E4/4 3.2%, E2/4 2.3%, and E2/2 0.2% in patients vs. 68.1%, 4.6%, 2.9%, 12%, 0.6%, and 4.6% in controls, respectively. Moreover, frequency of ApoE E2 allele was greater in the healthy controls than in patients (p<0.001) and the highest level of uric acid occurred in those with ApoE2/4 and E3/4 genotypes, whereas the lowest uric acid level occurred in those with ApoE E2/2 genotype. In addition, the subjects with the ApoE2 allele had a lower uric acid and LDL-C level than those with the ApoE3 allele and ApoE4 allele (p<0.05). The risk of developing hyperuricemia in subjects without the ApoE2 allele was 1.7 fold higher than those subjects with the ApoE2 allele.This study revealed frequencies and distributions of ApoE alleles and genotypes in Uygur males, which are different from Han Chinese. ApoE E4 was associated with a slightly higher risk of primary hyperuricemia, whereas ApoE E2 was associated with reduced risk of primary hyperuricemia and LDL-C level.CONCLUSIONSThis study revealed frequencies and distributions of ApoE alleles and genotypes in Uygur males, which are different from Han Chinese. ApoE E4 was associated with a slightly higher risk of primary hyperuricemia, whereas ApoE E2 was associated with reduced risk of primary hyperuricemia and LDL-C level. Background Apolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between ApoE polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China. Methods A total of 474 hyperuricemia patients and 518 healthy male controls were recruited from the Health Screening Center, Uygur region of Xinjiang, China and subjected to ApoE genotyping using a multiplex amplification refractory mutation system PCR. Results Apolipoprotein E3/3 genotype was the predominant type with a frequency of 67.7%, while E2/2 was lower than E4/4 in Uygur males. The frequencies of ApoE2, E3, and E4 alleles were 8.5%, 80.1% and 11.4%, respectively. Distribution of ApoE genotypes was significantly different in hyperuricemia patients from the healthy controls (p < 0.001). Particularly, the frequency of ApoE E3/3 was 71.7%, E2/3 9.3%, E3/4 9.3%, E4/4 3.2%, E2/4 2.3%, and E2/2 0.2% in patients vs. 68.1%, 4.6%, 2.9%, 12%, 0.6%, and 4.6% in controls, respectively. Moreover, frequency of ApoE E2 allele was greater in the healthy controls than in patients (p < 0.001) and the highest level of uric acid occurred in those with ApoE2/4 and E3/4 genotypes, whereas the lowest uric acid level occurred in those with ApoE E2/2 genotype. In addition, the subjects with the ApoE2 allele had a lower uric acid and LDL-C level than those with the ApoE3 allele and ApoE4 allele (p < 0.05). The risk of developing hyperuricemia in subjects without the ApoE2 allele was 1.7 fold higher than those subjects with the ApoE2 allele. Conclusions This study revealed frequencies and distributions of ApoE alleles and genotypes in Uygur males, which are different from Han Chinese. ApoE E4 was associated with a slightly higher risk of primary hyperuricemia, whereas ApoE E2 was associated with reduced risk of primary hyperuricemia and LDL-C level. Keywords: Apolipoprotein E, Polymorphisms, Primary hyperuricemia, Uygur Apolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between ApoE polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China. A total of 474 hyperuricemia patients and 518 healthy male controls were recruited from the Health Screening Center, Uygur region of Xinjiang, China and subjected to ApoE genotyping using a multiplex amplification refractory mutation system PCR. Apolipoprotein E3/3 genotype was the predominant type with a frequency of 67.7%, while E2/2 was lower than E4/4 in Uygur males. The frequencies of ApoE2, E3, and E4 alleles were 8.5%, 80.1% and 11.4%, respectively. Distribution of ApoE genotypes was significantly different in hyperuricemia patients from the healthy controls (p<0.001). Particularly, the frequency of ApoE E3/3 was 71.7%, E2/3 9.3%, E3/4 9.3%, E4/4 3.2%, E2/4 2.3%, and E2/2 0.2% in patients vs. 68.1%, 4.6%, 2.9%, 12%, 0.6%, and 4.6% in controls, respectively. Moreover, frequency of ApoE E2 allele was greater in the healthy controls than in patients (p<0.001) and the highest level of uric acid occurred in those with ApoE2/4 and E3/4 genotypes, whereas the lowest uric acid level occurred in those with ApoE E2/2 genotype. In addition, the subjects with the ApoE2 allele had a lower uric acid and LDL-C level than those with the ApoE3 allele and ApoE4 allele (p<0.05). The risk of developing hyperuricemia in subjects without the ApoE2 allele was 1.7 fold higher than those subjects with the ApoE2 allele. This study revealed frequencies and distributions of ApoE alleles and genotypes in Uygur males, which are different from Han Chinese. ApoE E4 was associated with a slightly higher risk of primary hyperuricemia, whereas ApoE E2 was associated with reduced risk of primary hyperuricemia and LDL-C level. Apolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between ApoE polymorphisms with hyperuricemia and uric acid metabolism in Uygur men, Xinjiang, China. A total of 474 hyperuricemia patients and 518 healthy male controls were recruited from the Health Screening Center, Uygur region of Xinjiang, China and subjected to ApoE genotyping using a multiplex amplification refractory mutation system PCR. Apolipoprotein E3/3 genotype was the predominant type with a frequency of 67.7%, while E2/2 was lower than E4/4 in Uygur males. The frequencies of ApoE2, E3, and E4 alleles were 8.5%, 80.1% and 11.4%, respectively. Distribution of ApoE genotypes was significantly different in hyperuricemia patients from the healthy controls (p < 0.001). Particularly, the frequency of ApoE E3/3 was 71.7%, E2/3 9.3%, E3/4 9.3%, E4/4 3.2%, E2/4 2.3%, and E2/2 0.2% in patients vs. 68.1%, 4.6%, 2.9%, 12%, 0.6%, and 4.6% in controls, respectively. Moreover, frequency of ApoE E2 allele was greater in the healthy controls than in patients (p < 0.001) and the highest level of uric acid occurred in those with ApoE2/4 and E3/4 genotypes, whereas the lowest uric acid level occurred in those with ApoE E2/2 genotype. In addition, the subjects with the ApoE2 allele had a lower uric acid and LDL-C level than those with the ApoE3 allele and ApoE4 allele (p < 0.05). The risk of developing hyperuricemia in subjects without the ApoE2 allele was 1.7 fold higher than those subjects with the ApoE2 allele. This study revealed frequencies and distributions of ApoE alleles and genotypes in Uygur males, which are different from Han Chinese. ApoE E4 was associated with a slightly higher risk of primary hyperuricemia, whereas ApoE E2 was associated with reduced risk of primary hyperuricemia and LDL-C level. |
| ArticleNumber | 25 |
| Audience | Academic |
| Author | Miao, Lei Wang, Xian-Min Yu, Jia-Hui Xin, Gao Yao, Hua Sun, Yu-Ping Luo, Li Zhang, Bei Ying, Lu Haliakpaer, Gulinizha Xia, He |
| Author_xml | – sequence: 1 givenname: Yu-Ping surname: Sun fullname: Sun, Yu-Ping organization: College of Basic Science, Xinjiang Medical University – sequence: 2 givenname: Bei surname: Zhang fullname: Zhang, Bei organization: College of Basic Science, Xinjiang Medical University – sequence: 3 givenname: Lei surname: Miao fullname: Miao, Lei organization: School of Public Health, Xinjiang Medical University – sequence: 4 givenname: Xian-Min surname: Wang fullname: Wang, Xian-Min organization: The Fourth Affiliated Hospital, Xinjiang Medical University – sequence: 5 givenname: Jia-Hui surname: Yu fullname: Yu, Jia-Hui organization: College of Basic Science, Xinjiang Medical University – sequence: 6 givenname: Li surname: Luo fullname: Luo, Li organization: The Key Laboratory of Metabolic Diseases, Department of Education, Xinjiang Uygur Autonomous Region, The First Affiliated Hospital, Xinjiang Medical University – sequence: 7 givenname: Lu surname: Ying fullname: Ying, Lu organization: The Key Laboratory of Metabolic Diseases, Department of Education, Xinjiang Uygur Autonomous Region, The First Affiliated Hospital, Xinjiang Medical University – sequence: 8 givenname: Gao surname: Xin fullname: Xin, Gao organization: The Fifth Affiliated Hospital, Xinjiang Medical University – sequence: 9 givenname: Gulinizha surname: Haliakpaer fullname: Haliakpaer, Gulinizha organization: The Municipal Hospital of Aletai – sequence: 10 givenname: He surname: Xia fullname: Xia, He organization: The Center for Disease Prevention and Control – sequence: 11 givenname: Hua surname: Yao fullname: Yao, Hua email: yaohua01@sina.com organization: The Key Laboratory of Metabolic Diseases, Department of Education, Xinjiang Uygur Autonomous Region, The First Affiliated Hospital, Xinjiang Medical University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25890021$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1002_dad2_12241 crossref_primary_10_3389_fgene_2018_00733 crossref_primary_10_1136_bmjopen_2015_010049 crossref_primary_10_1186_s12944_016_0205_8 crossref_primary_10_3389_fcvm_2022_1055790 crossref_primary_10_1007_s13577_021_00609_w crossref_primary_10_1111_ene_13378 crossref_primary_10_2217_pgs_2019_0048 crossref_primary_10_4103_ijmr_IJMR_1208_18 |
| Cites_doi | 10.1056/NEJMoa035700 10.1016/j.jacl.2011.06.017 10.1212/WNL.52.2.244 10.1186/1471-2458-11-832 10.1016/S0021-9258(18)88963-3 10.1185/030079904125002982 10.1111/1756-185X.12010 10.1161/01.ATV.8.1.1 10.1002/jcla.20083 10.1016/j.ehj.2012.11.002 10.1016/j.neuint.2009.09.016 10.1111/j.0954-6820.1987.tb09903.x 10.3109/13813455.2014.924145 10.1016/j.jstrokecerebrovasdis.2012.02.006 10.1097/SMJ.0000000000000082 10.4103/0019-5359.39613 10.1016/j.semnephrol.2011.08.004 10.1038/nature04001 10.1093/aje/155.6.487 10.1590/S0004-282X2001000100004 10.4274/jcrpe.521 10.1089/gtmb.2011.0379 10.1146/annurev.genom.1.1.507 10.1111/j.1600-0447.2005.00597.x 10.1136/ard.54.5.351 10.1210/jc.2004-1912 10.1093/clinchem/45.1.143 |
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| References | M Bazrgar (25_CR18) 2012; 16 B Liu (25_CR2) 2011; 11 F Cardona (25_CR7) 2005; 90 I Elmadbouh (25_CR28) 2013; 65 DY Ciftdogan (25_CR8) 2012; 6 S Sadigh-Eteghad (25_CR11) 2012; 17 J Davignon (25_CR14) 1988; 8 JE Eichner (25_CR15) 2002; 155 R Monastero (25_CR9) 2006; 113 H Nasiri (25_CR31) 2005; 19 HK Choi (25_CR4) 2004; 350 P van den Elzen (25_CR6) 2005; 437 HK Das (25_CR19) 1985; 260 PP Singh (25_CR29) 2008; 62 M Jacquier (25_CR10) 2001; 59 UK Misra (25_CR23) 2013; 22 Y Cui (25_CR24) 2002; 23 YH Rho (25_CR3) 2011; 31 P Miao (25_CR25) 2005; 4 F Cardona (25_CR17) 2003; 42 GG Donohoe (25_CR30) 1999; 45 DS Kim (25_CR33) 2000; 20 TL Innerarity (25_CR20) 1987; 715 RW Mahley (25_CR13) 2000; 1 DM Hallman (25_CR21) 1991; 49 M Alderman (25_CR22) 2004; 20 ME Atabek (25_CR26) 2012; 4 KD Torralba (25_CR5) 2012; 15 E Karis (25_CR32) 2014; 107 Y Moriwaki (25_CR27) 1995; 54 G Friedman (25_CR16) 1999; 52 S Ciarla (25_CR1) 2014; 120 CN Ferreira (25_CR12) 2010; 56 3035881 - Acta Med Scand Suppl. 1987;715:51-9 15025846 - Curr Med Res Opin. 2004 Mar;20(3):369-79 3277611 - Arteriosclerosis. 1988 Jan-Feb;8(1):1-21 19819279 - Neurochem Int. 2010 Jan;56(1):177-82 22410653 - J Stroke Cerebrovasc Dis. 2013 Aug;22(6):758-63 16208376 - Nature. 2005 Oct 6;437(7060):906-10 15014182 - N Engl J Med. 2004 Mar 11;350(11):1093-103 22000647 - Semin Nephrol. 2011 Sep;31(5):410-9 12626798 - Rheumatology (Oxford). 2003 Mar;42(3):468-72 11299424 - Arq Neuropsiquiatr. 2001 Mar;59(1):11-7 24914748 - Arch Physiol Biochem. 2014 Jul;120(3):119-22 3922972 - J Biol Chem. 1985 May 25;260(10):6240-7 7794039 - Ann Rheum Dis. 1995 May;54(5):351-4 16302208 - J Clin Lab Anal. 2005;19(6):229-32 22264578 - J Clin Lipidol. 2012 Jan-Feb;6(1):81-7 23253231 - Int J Rheum Dis. 2012 Dec;15(6):499-506 22394699 - J Clin Res Pediatr Endocrinol. 2012 Mar;4(1):8-13 22540367 - Genet Test Mol Biomarkers. 2012 Aug;16(8):920-3 15713714 - J Clin Endocrinol Metab. 2005 May;90(5):2972-5 23022896 - Neurosciences (Riyadh). 2012 Oct;17(4):321-6 22032610 - BMC Public Health. 2011;11:832 9932938 - Neurology. 1999 Jan 15;52(2):244-8 9895356 - Clin Chem. 1999 Jan;45(1):143-6 16390371 - Acta Psychiatr Scand. 2006 Jan;113(1):59-63 11701639 - Annu Rev Genomics Hum Genet. 2000;1:507-37 18376083 - Indian J Med Sci. 2008 Mar;62(3):105-12 1867194 - Am J Hum Genet. 1991 Aug;49(2):338-49 24937517 - South Med J. 2014 Apr;107(4):235-41 11882522 - Am J Epidemiol. 2002 Mar 15;155(6):487-95 |
| References_xml | – volume: 350 start-page: 1093 issue: 11 year: 2004 ident: 25_CR4 publication-title: N Engl J Med doi: 10.1056/NEJMoa035700 – volume: 6 start-page: 81 issue: 1 year: 2012 ident: 25_CR8 publication-title: J Clin Lipidol doi: 10.1016/j.jacl.2011.06.017 – volume: 49 start-page: 338 issue: 2 year: 1991 ident: 25_CR21 publication-title: Am J Hum Genet – volume: 23 start-page: 2278 issue: 12 year: 2002 ident: 25_CR24 publication-title: Chem J Chin Univ – volume: 52 start-page: 244 issue: 2 year: 1999 ident: 25_CR16 publication-title: Neurology doi: 10.1212/WNL.52.2.244 – volume: 11 start-page: 832 year: 2011 ident: 25_CR2 publication-title: BMC Public Health doi: 10.1186/1471-2458-11-832 – volume: 260 start-page: 6240 issue: 10 year: 1985 ident: 25_CR19 publication-title: J Biol Chem doi: 10.1016/S0021-9258(18)88963-3 – volume: 20 start-page: 369 issue: 3 year: 2004 ident: 25_CR22 publication-title: Curr Med Res Opin doi: 10.1185/030079904125002982 – volume: 4 start-page: 1 year: 2005 ident: 25_CR25 publication-title: The Western Regions Studies – volume: 15 start-page: 499 issue: 6 year: 2012 ident: 25_CR5 publication-title: Int J Rheum Dis doi: 10.1111/1756-185X.12010 – volume: 8 start-page: 1 issue: 1 year: 1988 ident: 25_CR14 publication-title: Arteriosclerosis doi: 10.1161/01.ATV.8.1.1 – volume: 19 start-page: 229 issue: 6 year: 2005 ident: 25_CR31 publication-title: J Clin Lab Anal doi: 10.1002/jcla.20083 – volume: 65( start-page: 71 issue: 2 year: 2013 ident: 25_CR28 publication-title: The Egyptian Heart Journal doi: 10.1016/j.ehj.2012.11.002 – volume: 56 start-page: 177 issue: 1 year: 2010 ident: 25_CR12 publication-title: Neurochem Int doi: 10.1016/j.neuint.2009.09.016 – volume: 715 start-page: 51 year: 1987 ident: 25_CR20 publication-title: Acta Med Scand Suppl doi: 10.1111/j.0954-6820.1987.tb09903.x – volume: 120 start-page: 119 issue: 3) year: 2014 ident: 25_CR1 publication-title: Arch Physiol Biochem doi: 10.3109/13813455.2014.924145 – volume: 22 start-page: 758 issue: 6 year: 2013 ident: 25_CR23 publication-title: J Stroke Cerebrovasc Dis doi: 10.1016/j.jstrokecerebrovasdis.2012.02.006 – volume: 107 start-page: 235 issue: 4 year: 2014 ident: 25_CR32 publication-title: South Med J doi: 10.1097/SMJ.0000000000000082 – volume: 62 start-page: 105 issue: 3 year: 2008 ident: 25_CR29 publication-title: Indian J Med Sci doi: 10.4103/0019-5359.39613 – volume: 31 start-page: 410 issue: 5 year: 2011 ident: 25_CR3 publication-title: Semin Nephrol doi: 10.1016/j.semnephrol.2011.08.004 – volume: 437 start-page: 906 issue: 7060 year: 2005 ident: 25_CR6 publication-title: Nature doi: 10.1038/nature04001 – volume: 155 start-page: 487 issue: 6 year: 2002 ident: 25_CR15 publication-title: Am J Epidemiol doi: 10.1093/aje/155.6.487 – volume: 20 start-page: 150 issue: 2 year: 2000 ident: 25_CR33 publication-title: Korean J Clin Pathol – volume: 59 start-page: 11 issue: 1 year: 2001 ident: 25_CR10 publication-title: Arq Neuropsiquiatr doi: 10.1590/S0004-282X2001000100004 – volume: 42 start-page: 468 issue: 3 year: 2003 ident: 25_CR17 publication-title: Rheumatology (Oxford) – volume: 4 start-page: 8 issue: 1 year: 2012 ident: 25_CR26 publication-title: J Clin Res Pediatr Endocrinol doi: 10.4274/jcrpe.521 – volume: 16 start-page: 920 issue: 8 year: 2012 ident: 25_CR18 publication-title: Genet Test Mol Biomarkers doi: 10.1089/gtmb.2011.0379 – volume: 1 start-page: 507 year: 2000 ident: 25_CR13 publication-title: Annu Rev Genomics Hum Genet doi: 10.1146/annurev.genom.1.1.507 – volume: 113 start-page: 59 issue: 1 year: 2006 ident: 25_CR9 publication-title: Acta Psychiatr Scand doi: 10.1111/j.1600-0447.2005.00597.x – volume: 54 start-page: 351 issue: 5 year: 1995 ident: 25_CR27 publication-title: Ann Rheum Dis doi: 10.1136/ard.54.5.351 – volume: 90 start-page: 2972 issue: 5 year: 2005 ident: 25_CR7 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-1912 – volume: 45 start-page: 143 issue: 1 year: 1999 ident: 25_CR30 publication-title: Clin Chem doi: 10.1093/clinchem/45.1.143 – volume: 17 start-page: 32 issue: 4 year: 2012 ident: 25_CR11 publication-title: Neurosciences (Riyadh) – reference: 11701639 - Annu Rev Genomics Hum Genet. 2000;1:507-37 – reference: 23253231 - Int J Rheum Dis. 2012 Dec;15(6):499-506 – reference: 22032610 - BMC Public Health. 2011;11:832 – reference: 18376083 - Indian J Med Sci. 2008 Mar;62(3):105-12 – reference: 19819279 - Neurochem Int. 2010 Jan;56(1):177-82 – reference: 9895356 - Clin Chem. 1999 Jan;45(1):143-6 – reference: 1867194 - Am J Hum Genet. 1991 Aug;49(2):338-49 – reference: 11882522 - Am J Epidemiol. 2002 Mar 15;155(6):487-95 – reference: 15014182 - N Engl J Med. 2004 Mar 11;350(11):1093-103 – reference: 23022896 - Neurosciences (Riyadh). 2012 Oct;17(4):321-6 – reference: 15025846 - Curr Med Res Opin. 2004 Mar;20(3):369-79 – reference: 24914748 - Arch Physiol Biochem. 2014 Jul;120(3):119-22 – reference: 16302208 - J Clin Lab Anal. 2005;19(6):229-32 – reference: 22394699 - J Clin Res Pediatr Endocrinol. 2012 Mar;4(1):8-13 – reference: 11299424 - Arq Neuropsiquiatr. 2001 Mar;59(1):11-7 – reference: 22410653 - J Stroke Cerebrovasc Dis. 2013 Aug;22(6):758-63 – reference: 16390371 - Acta Psychiatr Scand. 2006 Jan;113(1):59-63 – reference: 16208376 - Nature. 2005 Oct 6;437(7060):906-10 – reference: 7794039 - Ann Rheum Dis. 1995 May;54(5):351-4 – reference: 3277611 - Arteriosclerosis. 1988 Jan-Feb;8(1):1-21 – reference: 12626798 - Rheumatology (Oxford). 2003 Mar;42(3):468-72 – reference: 15713714 - J Clin Endocrinol Metab. 2005 May;90(5):2972-5 – reference: 22000647 - Semin Nephrol. 2011 Sep;31(5):410-9 – reference: 3035881 - Acta Med Scand Suppl. 1987;715:51-9 – reference: 3922972 - J Biol Chem. 1985 May 25;260(10):6240-7 – reference: 22264578 - J Clin Lipidol. 2012 Jan-Feb;6(1):81-7 – reference: 22540367 - Genet Test Mol Biomarkers. 2012 Aug;16(8):920-3 – reference: 9932938 - Neurology. 1999 Jan 15;52(2):244-8 – reference: 24937517 - South Med J. 2014 Apr;107(4):235-41 |
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| Snippet | Background
Apolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between
ApoE
polymorphisms... Apolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between ApoE polymorphisms with... Background Apolipoprotein E (ApoE) participates in lipoprotein metabolism and immune regulation. This study assessed association between ApoE polymorphisms... |
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| SubjectTerms | Alleles Amino acids Apolipoprotein E2 - genetics Apolipoprotein E3 - genetics Apolipoprotein E4 - genetics Apolipoproteins Apolipoproteins E - genetics Asian Continental Ancestry Group - genetics Biomedical and Life Sciences Case-Control Studies China - epidemiology Clinical Nutrition European Continental Ancestry Group - genetics Genetic aspects Genetic Association Studies Genotype Humans Hyperuricemia - etiology Hyperuricemia - genetics Life Sciences Lipidology Male Medical Biochemistry Medical screening Middle Aged Physiological aspects Polymorphism, Genetic - genetics Risk Factors Uric Acid - blood Uric Acid - metabolism |
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| Title | Association of apolipoprotein E (ApoE) polymorphisms with risk of primary hyperuricemia in Uygur men, Xinjiang, China |
| URI | https://link.springer.com/article/10.1186/s12944-015-0025-2 https://www.ncbi.nlm.nih.gov/pubmed/25890021 https://www.proquest.com/docview/1684432204 https://pubmed.ncbi.nlm.nih.gov/PMC4446952 |
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