HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 46; pp. E7212 - E7221
• Main Authors: Chakraborty, Damayanti, Cui, Wei, Rosario, Gracy X., Scott, Regan L., Dhakal, Pramod, Renaud, Stephen J., Tachibana, Makoto, Rumi, M. A. Karim, Mason, Clifford W., Krieg, Adam J., Soares, Michael J.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 15.11.2016
• Series: PNAS Plus
• Subjects: Biological Sciences; Genes; Genotype & phenotype; Hypoxia; Mutation; Peptides; PNAS Plus; Stem cells; hypoxia; placenta; plasticity; epigenetics; trophoblast invasion

The hemochorial placenta develops from the coordinated multi-lineage differentiation of trophoblast stem (TS) cells. An invasive trophoblast cell lineage remodels uterine spiral arteries, facilitating nutrient flow, failure of which is associated with pathological conditions such as preeclampsia, in...