Real-time measurement of small molecules directly in awake, ambulatory animals

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 4; pp. 645 - 650
• Main Authors: Arroyo-Currás, Netzahualcóyotl, Somerson, Jacob, Vieira, Philip A., Ploense, Kyle L., Kippin, Tod E., Plaxco, Kevin W.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 24.01.2017
• Subjects: Animals; Aptamers, Nucleotide - metabolism; Biological Sciences; Biomarkers; Biosensing Techniques - methods; Cattle; Detection limits; Electrochemistry; Humans; Limit of Detection; Male; Medical treatment; Metabolites; Pharmaceutical Preparations - blood; Pharmaceutical Preparations - metabolism; Pharmacokinetics; Physical Sciences; Rats; Rats, Sprague-Dawley; Sensors; Small Molecule Libraries - metabolism; precision medicine; in vivo; square-wave voltammetry; aptamer; E-DNA

The development of a technology capable of tracking the levels of drugs, metabolites, and biomarkers in the body continuously and in real time would advance our understanding of health and our ability to detect and treat disease. It would, for example, enable therapies guided by high-resolution, pat...