Down-regulation of Myeloid Cell Leukemia-1 through Inhibiting Erk/Pin 1 Pathway by Sorafenib Facilitates Chemosensitization in Breast Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 68; no. 15; pp. 6109 - 6117
• Main Authors: Ding, Qingqing, Huo, Longfei, Yang, Jer-Yen, Xia, Weiya, Wei, Yongkun, Liao, Yong, Chang, Chun-Ju, Yang, Yan, Lai, Chien-Chen, Lee, Dung-Fang, Yen, Chia-Jui, Chen, Yun-Ju Rita, Hsu, Jung-Mao, Kuo, Hsu-Ping, Lin, Chun-Yi, Tsai, Fuu-Jen, Li, Long-Yuan, Tsai, Chang-Hai, Hung, Mien-Chie
• Format: Journal Article
• Language: English
• Published: United States 01.08.2008
• Subjects: Antineoplastic Agents - pharmacology; Benzenesulfonates - pharmacology; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Line, Tumor; Down-Regulation; Humans; MAP Kinase Signaling System; Mutagenesis, Site-Directed; Myeloid Cell Leukemia Sequence 1 Protein; Niacinamide - analogs & derivatives; NIMA-Interacting Peptidylprolyl Isomerase; Peptidylprolyl Isomerase - metabolism; Phenylurea Compounds; Phosphorylation; Proto-Oncogene Proteins c-bcl-2 - physiology; Pyridines - pharmacology; Sorafenib

Myeloid cell leukemia-1 (Mcl-1), a Bcl-2–like antiapoptotic protein, plays a role in cell immortalization and chemoresistance in a number of human malignancies. A peptidyl-prolyl cis/trans isomerase, Pin1 is involved in many cellular events, such as cell cycle progression, cell proliferation, and di...