SIRT5 stabilizes mitochondrial glutaminase and supports breast cancer tumorigenesis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 52; pp. 26625 - 26632
• Main Authors: Greene, Kai Su, Lukey, Michael J., Wang, Xueying, Blank, Bryant, Druso, Joseph E., Lin, Miao-chong J., Stalnecker, Clint A., Zhang, Chengliang, Abril, Yashira Negrón, Erickson, Jon W., Wilson, Kristin F., Lin, Hening, Weiss, Robert S., Cerione, Richard A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 26.12.2019
• Subjects: Biological Sciences; Breast cancer; Cancer; Glutaminase; Glutamine; Lysine; Metabolic pathways; Metabolism; Mitochondria; NAD; Transformed cells; Tumorigenesis; Ubiquitin; glutaminase; SIRT5; cancer; metabolism; sirtuin

The mitochondrial enzyme glutaminase (GLS) is frequently up-regulated during tumorigenesis and is being evaluated as a target for cancer therapy. GLS catalyzes the hydrolysis of glutamine to glutamate, which then supplies diverse metabolic pathways with carbon and/or nitrogen. Here, we report that S...