Soluble matrix protein is a potent modulator of mesenchymal stem cell performance

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 6; pp. 2042 - 2051
• Main Authors: Yeo, Giselle C., Weiss, Anthony S.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 05.02.2019
• Series: PNAS Plus
• Subjects: Biological Sciences; Cell Movement - drug effects; Cell Proliferation - drug effects; Cell surface; Deformation mechanisms; Elastic deformation; Extracellular matrix; Extracellular Matrix Proteins - metabolism; Extracellular Matrix Proteins - pharmacology; Fibroblast Growth Factor 2; Fibronectin; Growth factors; Homing; Insulin; Insulin-Like Growth Factor I - drug effects; Integrin alphaVbeta3; Integrins; Intercellular Signaling Peptides and Proteins - metabolism; Matrix protein; Mechanical properties; Mesenchymal Stem Cells - drug effects; Mesenchymal Stem Cells - metabolism; Mesenchyme; PNAS Plus; Proteins; Receptors, Vitronectin; Stem cells; Substrates; Synergistic effect; Tropoelastin; Tropoelastin - metabolism; Wound Healing; growth factor; migration; mesenchymal stem cells; expansion; tropoelastin

We challenge the conventional designation of structural matrix proteins primarily as supporting scaffolds for resident cells. The extracellular matrix protein tropoelastin is classically regarded as a structural component that confers mechanical strength and resilience to tissues subject to repetiti...