Agrobacteria reprogram virulence gene expression by controlled release of host-conjugated signals

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 116; no. 44; pp. 22331 - 22340
• Main Authors: Wang, Chao, Ye, Fuzhou, Chang, Changqing, Liu, Xiaoling, Wang, Jianhe, Wang, Jinpei, Yan, Xin-Fu, Fu, Qinqin, Zhou, Jianuan, Chen, Shaohua, Gao, Yong-Gui, Zhang, Lian-Hui
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 29.10.2019
• Series: PNAS Plus
• Subjects: Agrobacterium tumefaciens - genetics; Agrobacterium tumefaciens - pathogenicity; Arabidopsis - metabolism; Arabidopsis - microbiology; Bacteria; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biological Sciences; Controlled release; Disruption; Gene expression; Host-Pathogen Interactions; Hydrolase; Hydrolases - genetics; Hydrolases - metabolism; Infections; Metabolites; Mutation; PNAS Plus; Salicylic acid; Salicylic Acid - metabolism; Shutdowns; Signal Transduction; Sucrose; Sucrose - metabolism; Sugar; Transcription Factors - genetics; Transcription Factors - metabolism; Tumors; Virulence; Virulence Factors - genetics; Agrobacterium; glucosidase; cost–pathogen interaction; sucrose; chemical signaling

It is highly intriguing how bacterial pathogens can quickly shut down energy-costly infection machinery once successful infection is established. This study depicts that mutation of repressor SghR increases the expression of hydrolase SghA in Agrobacterium tumefaciens, which releases plant defense s...