Severe fetal anemia and hydrops fetalis associated with compound heterozygosity for Hb Zurich-Albisrieden (HBA2:c.178G>C) and Hb Quong Sze (HBA2:c.377T>C)

• Published in: Journal of international medical research Vol. 49; no. 7; p. 3000605211031429
• Main Authors: Du, Li, Bao, Xiuqin, He, Wei, Qin, Danqing, Wang, Jicheng, Xiong, Ying, Shi, Xiaomei, Ding, Hongke, Yao, Cuize, Wu, Jing
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.07.2021; Sage Publications Ltd; SAGE Publishing
• Subjects: Anemia; Case Reports; Fetuses; hydrops fetalis; Hemoglobin Zurich-Albisrieden; hemoglobin Quong Sze; fetal anemia; cardiomegaly; prenatal diagnosis

We report on a fetus with cardiomegaly and increased middle cerebral artery-peak systolic velocity at 25 weeks of gestation. Severe fetal anemia (hemoglobin (Hb) level 37 g/L) was confirmed by cordocentesis. Hb analysis showed that Hb Bart’s was 9% in cord blood. Molecular analysis of the proband’s...