Role of the nucleotidyl cyclase helical domain in catalytically active dimer formation - Vercellino, Irene; Rezabkova, Lenka; Olieric, Vincent; Polyhach, Yevhen; Weinert, Tobias; Kammerer, Richard A.; Jeschke, Gunnar; Korkhov, Volodymyr M. (Proceedings of the National Academy of Sciences - PNAS, 2017)
Keywords: Adenylyl Cyclases - chemistry; Adenylyl Cyclases - genetics; Adenylyl Cyclases - metabolism; Amino Acid Substitution; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biological Sciences; Catalysis; Catalytic Domain; Conserved Sequence; Crystallography, X-Ray; Cytosol - enzymology; Dimerization; Enzyme Activation; Enzyme Stability; Enzymes; Experiments; Guanylate cyclase; Guanylate Cyclase - chemistry; Guanylate Cyclase - genetics; Humans; Integrals; Machinery and equipment; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins - chemistry; Mutant Proteins - genetics; Mutant Proteins - metabolism; Mutation; Mycobacterium avium Complex - enzymology; Mycobacterium avium Complex - genetics; PNAS Plus; Protein Conformation; Protein families; Protein structure; Proteins; Receptors, Cell Surface - chemistry; Receptors, Cell Surface - genetics; Retina; Sequence Alignment; Sequence Analysis, Protein; Signal transduction; Signaling; adenylyl cyclase; dimerization; helical domain; Cya; X-ray structure