Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division

• Published in: The Journal of biological chemistry Vol. 291; no. 33; pp. 17001 - 17008
• Main Authors: Gholkar, Ankur A., Cheung, Keith, Williams, Kevin J., Lo, Yu-Chen, Hamideh, Shadia A., Nnebe, Chelsea, Khuu, Cindy, Bensinger, Steven J., Torres, Jorge Z.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 12.08.2016; American Society for Biochemistry and Molecular Biology
• Subjects: Accelerated Communications; Betulin; cancer; cell death; cell division; Cell Division - drug effects; Fatostatin; G2 Phase - drug effects; HeLa Cells; Humans; lipid metabolism; mitosis; Neoplasm Proteins - antagonists & inhibitors; Neoplasm Proteins - metabolism; Neoplasms - drug therapy; Neoplasms - metabolism; Neoplasms - pathology; PF-429242; Pyridines - pharmacology; Spindle Apparatus - metabolism; SREBP; Sterol Regulatory Element Binding Proteins - antagonists & inhibitors; Sterol Regulatory Element Binding Proteins - metabolism; Thiazoles - pharmacology; Betulin; Fatostatin; SREBP; cell death; lipid metabolism; cell division; PF-429242; cancer; mitosis

The sterol regulatory element-binding protein (SREBP) transcription factors have become attractive targets for pharmacological inhibition in the treatment of metabolic diseases and cancer. SREBPs are critical for the production and metabolism of lipids and cholesterol, which are essential for cellul...