Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition

• Published in: Journal of lipid research Vol. 61; no. 1; pp. 54 - 69
• Main Authors: Honda, Akira, Miyazaki, Teruo, Iwamoto, Junichi, Hirayama, Takeshi, Morishita, Yukio, Monma, Tadakuni, Ueda, Hajime, Mizuno, Seiya, Sugiyama, Fumihiro, Takahashi, Satoru, Ikegami, Tadashi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.01.2020; The American Society for Biochemistry and Molecular Biology; Elsevier
• Subjects: 7α-hydroxy-4-cholesten-3-one 12α-hydroxylase; Animals; Aryl Hydrocarbon Hydroxylases - deficiency; Aryl Hydrocarbon Hydroxylases - genetics; Aryl Hydrocarbon Hydroxylases - metabolism; Bile Acids and Salts - chemistry; Bile Acids and Salts - metabolism; Chenodeoxycholic Acid - chemistry; Chenodeoxycholic Acid - metabolism; cholesterol 7α-hydroxylase; CRISPR-Cas9; CYP2A12; CYP2C70; Cytochrome P-450 Enzyme System - deficiency; Cytochrome P-450 Enzyme System - genetics; Cytochrome P-450 Enzyme System - metabolism; cytochrome P450; cytokines; Disease Models, Animal; farnesoid X receptor; Female; Hydrophobic and Hydrophilic Interactions; knockout mouse; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Structure; pregnane X receptor; Rats; Rats, Sprague-Dawley; Steroid Hydroxylases - deficiency; Steroid Hydroxylases - genetics; Steroid Hydroxylases - metabolism; CYP2A12; farnesoid X receptor; CRISPR-Cas9; cholesterol 7α-hydroxylase; cytokines; pregnane X receptor; cytochrome P450; CYP2C70; knockout mouse; 7α-hydroxy-4-cholesten-3-one 12α-hydroxylase

The bile acid (BA) composition in mice is substantially different from that in humans. Chenodeoxycholic acid (CDCA) is an end product in the human liver; however, mouse Cyp2c70 metabolizes CDCA to hydrophilic muricholic acids (MCAs). Moreover, in humans, the gut microbiota converts the primary BAs,...