Inactivation of Thrombin by a Fucosylated Chondroitin Sulfate from Echinoderm

• Published in: Thrombosis research Vol. 102; no. 2; pp. 167 - 176
• Main Authors: Mourão, Paulo A.S, Boisson-Vidal, Catherine, Tapon-Bretaudière, Jacqueline, Drouet, Bruno, Bros, Andrée, Fischer, Anne-Marie
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Ltd 15.04.2001; Elsevier Science
• Subjects: Animals; Anticoagulant activity; Anticoagulants - chemistry; Anticoagulants - pharmacology; Biological and medical sciences; Blood Coagulation Tests; Blood. Blood coagulation. Reticuloendothelial system; Chondroitin Sulfates - chemistry; Chondroitin Sulfates - pharmacology; Echinodermata - chemistry; Fucose - analysis; Fucose - chemistry; Fucosylated chondroitin sulfate; Hemostatics - antagonists & inhibitors; Humans; Inhibitory Concentration 50; Kinetics; Medical sciences; Molecular Structure; Pharmacology. Drug treatments; Sea Cucumbers - chemistry; Sulfated fucan; Thrombin - antagonists & inhibitors; Thrombin inhibition; Sulfated fucan; Thrombin inhibition; Anticoagulant activity; Fucosylated chondroitin sulfate; Peptidases; Serine endopeptidases; Enzyme; Echinodermata; Animal; Hydrolases; Thrombin; Anticoagulant; Chondroitin sulfate; Invertebrata; Biological activity

A polysaccharide extracted from the sea cucumber body wall has the same backbone structure as the mammalian chondroitin sulfate, but some of the glucuronic acid residues display sulfated fucose branches. These branches confer high anticoagulant activity to the polysaccharide. Since the sea cucumber...