Mammalian Period represses and de-represses transcription by displacing CLOCK–BMAL1 from promoters in a Cryptochrome-dependent manner

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 41; pp. E6072 - E6079
• Main Authors: Chiou, Yi-Ying, Yang, Yanyan, Rashid, Naim, Ye, Rui, Selby, Christopher P., Sancar, Aziz
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 11.10.2016
• Series: PNAS Plus
• Subjects: Biological Sciences; Circadian rhythms; Genes; Mammals; PNAS Plus; Proteins; Ribonucleic acid; RNA; Transcription factors; Period; circadian; activator; transcription; DNA binding

The mammalian circadian clock is based on a transcription-translation feedback loop (TTFL) consolidated by secondary loops. In the primary TTFL, the circadian locomotor output cycles kaput (CLOCK)–brain and muscle Arnt-like protein-1 (BMAL1) heterodimer acts as the transcriptional activator, and Cry...