Urinary metabonomic study of the surface layer of Poria cocos as an effective treatment for chronic renal injury in rats

• Published in: Journal of ethnopharmacology Vol. 148; no. 2; pp. 403 - 410
• Main Authors: Zhao, Ying-Yong, Li, Hai-Tao, Feng, Ya-Long, Bai, Xu, Lin, Rui-Chao
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 09.07.2013
• Subjects: adenine; Adenine - metabolism; algorithms; amino acid metabolism; animal models; Animals; biochemical pathways; biomarkers; Biomarkers - metabolism; Chromatography, High Pressure Liquid; Chromatography, High Pressure Liquid - methods; Chronic kidney disease; Cocos; creatine; data collection; discriminant analysis; Diuretics; Diuretics - pharmacology; drug effects; drug therapy; Drugs, Chinese Herbal; Drugs, Chinese Herbal - pharmacology; edema; Edema - drug therapy; fungi; hypoxanthine; Kidney; Kidney - drug effects; Kidney - metabolism; Kidney Failure, Chronic; Kidney Failure, Chronic - drug therapy; Kidney Failure, Chronic - metabolism; Kidney Failure, Chronic - urine; kidneys; least squares; Male; mass spectrometry; Mass spectrometryElevated Energy; Medicine, Chinese Traditional; Medicine, Chinese Traditional - methods; metabolism; Metabolomics; Metabolomics - methods; Metabonomics; methionine; methods; pharmacology; phenylalanine; Plant Preparations; Plant Preparations - pharmacology; Poria; Poria cocos; principal component analysis; Principal Component Analysis - methods; Rats; Rats, Sprague-Dawley; renoprotective effect; Ultra performance liquid chromatography; Urination; urine; Wolfiporia; Wolfiporia cocos; xanthurenic acid; Ultra performance liquid chromatography; Poria cocos; PLS-DA; Chronic kidney disease; Mass spectrometryElevated Energy; FLP; PCA; CRF; Metabonomics; BPI; CKD; UPLC Q-TOF/HSMS; MSE; TCM

Poria cocos Wolf (Polyporaceae) is a well-known medicinal fungus. The epidermis of the sclerotia (“Fu-Ling-Pi” in Chinese) is used as a diuretic and traditionally used for promoting urination and reduce edema. Traditional Chinese medicines (TCM) treat many diseases through multi-components, multi-wa...