Urinary metabonomic study of the surface layer of Poria cocos as an effective treatment for chronic renal injury in rats
Poria cocos Wolf (Polyporaceae) is a well-known medicinal fungus. The epidermis of the sclerotia (“Fu-Ling-Pi” in Chinese) is used as a diuretic and traditionally used for promoting urination and reduce edema. Traditional Chinese medicines (TCM) treat many diseases through multi-components, multi-wa...
Saved in:
| Published in | Journal of ethnopharmacology Vol. 148; no. 2; pp. 403 - 410 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Ireland
Elsevier Ireland Ltd
09.07.2013
|
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Poria cocos Wolf (Polyporaceae) is a well-known medicinal fungus. The epidermis of the sclerotia (“Fu-Ling-Pi” in Chinese) is used as a diuretic and traditionally used for promoting urination and reduce edema.
Traditional Chinese medicines (TCM) treat many diseases through multi-components, multi-ways and multi-targets. However, the molecular mechanisms of TCM are not yet well understood. In the present work, ultra performance liquid chromatography-based metabonomics analysis was applied to investigate the urinary metabolite profiling of the renoprotective effect of FLP on adenine-induced chronic kidney disease (CKD) rat model and involved possible mechanism.
A metabonomic approach based on ultra performance liquid chromatography coupled with quadrupole time-of-flight high-sensitivity mass spectrometry and a novel mass spectrometryElevated Energy data collection technique was developed. The resulting dataset was analyzed by principal component analysis and partial least squares discriminant analysis. The identification of all potential biomarkers was performed using reference standard by comparing their mass spectra, MSE fragments information, isotopic pattern and MassLynx i-FIT algorithm.
By partial least squares-discriminate analysis, 15 biomarkers in rat urine were identified and 11 of them were related to the pathway of adenine metabolism and amino acid metabolism. Among these biomarkers, eight biomarkers like adenine, l-acetylcarnitine, 8-hydroxyadenine, hypoxanthine, creatine, methionine, phytosphingosine and phenylalanine were reversed to the control level in FLP-treated group and six biomarkers like 2,8-dihydroxyadenine, indole-3-carboxylic acid, 3-methyldioxyindole, ethyl-N2-acetyl-l-argininate, 3-O-methyldopa and xanthurenic acid were reversed to high control group by FLP, which indicates that the urinary metabolic pattern significantly changed after FLP treatment.
Our study indicates that FLP treatment can ameliorate CKD by intervening in some dominating metabolic pathways, such as adenine metabolism and amino acid metabolism. The metabonomic results not only supplied a systematic view of the development and progression of CKD and mechanism studies of FLP but also provided the theoretical basis for the prevention or treatment of CKD.
[Display omitted] |
|---|---|
| AbstractList | Poria cocos Wolf (Polyporaceae) is a well-known medicinal fungus. The epidermis of the sclerotia ("Fu-Ling-Pi" in Chinese) is used as a diuretic and traditionally used for promoting urination and reduce edema.
Traditional Chinese medicines (TCM) treat many diseases through multi-components, multi-ways and multi-targets. However, the molecular mechanisms of TCM are not yet well understood. In the present work, ultra performance liquid chromatography-based metabonomics analysis was applied to investigate the urinary metabolite profiling of the renoprotective effect of FLP on adenine-induced chronic kidney disease (CKD) rat model and involved possible mechanism.
A metabonomic approach based on ultra performance liquid chromatography coupled with quadrupole time-of-flight high-sensitivity mass spectrometry and a novel mass spectrometry(Elevated Energy) data collection technique was developed. The resulting dataset was analyzed by principal component analysis and partial least squares discriminant analysis. The identification of all potential biomarkers was performed using reference standard by comparing their mass spectra, MS(E) fragments information, isotopic pattern and MassLynx i-FIT algorithm.
By partial least squares-discriminate analysis, 15 biomarkers in rat urine were identified and 11 of them were related to the pathway of adenine metabolism and amino acid metabolism. Among these biomarkers, eight biomarkers like adenine, L-acetylcarnitine, 8-hydroxyadenine, hypoxanthine, creatine, methionine, phytosphingosine and phenylalanine were reversed to the control level in FLP-treated group and six biomarkers like 2,8-dihydroxyadenine, indole-3-carboxylic acid, 3-methyldioxyindole, ethyl-N2-acetyl-L-argininate, 3-O-methyldopa and xanthurenic acid were reversed to high control group by FLP, which indicates that the urinary metabolic pattern significantly changed after FLP treatment.
Our study indicates that FLP treatment can ameliorate CKD by intervening in some dominating metabolic pathways, such as adenine metabolism and amino acid metabolism. The metabonomic results not only supplied a systematic view of the development and progression of CKD and mechanism studies of FLP but also provided the theoretical basis for the prevention or treatment of CKD. ETHNOPHARMACOLOGICAL RELEVANCE: Poria cocos Wolf (Polyporaceae) is a well-known medicinal fungus. The epidermis of the sclerotia (“Fu-Ling-Pi” in Chinese) is used as a diuretic and traditionally used for promoting urination and reduce edema. AIM OF THE STUDY: Traditional Chinese medicines (TCM) treat many diseases through multi-components, multi-ways and multi-targets. However, the molecular mechanisms of TCM are not yet well understood. In the present work, ultra performance liquid chromatography-based metabonomics analysis was applied to investigate the urinary metabolite profiling of the renoprotective effect of FLP on adenine-induced chronic kidney disease (CKD) rat model and involved possible mechanism. MATERIAL AND METHODS: A metabonomic approach based on ultra performance liquid chromatography coupled with quadrupole time-of-flight high-sensitivity mass spectrometry and a novel mass spectrometryᴱˡᵉᵛᵃᵗᵉᵈ ᴱⁿᵉʳᵍʸ data collection technique was developed. The resulting dataset was analyzed by principal component analysis and partial least squares discriminant analysis. The identification of all potential biomarkers was performed using reference standard by comparing their mass spectra, MSᴱ fragments information, isotopic pattern and MassLynx i-FIT algorithm. RESULTS: By partial least squares-discriminate analysis, 15 biomarkers in rat urine were identified and 11 of them were related to the pathway of adenine metabolism and amino acid metabolism. Among these biomarkers, eight biomarkers like adenine, l-acetylcarnitine, 8-hydroxyadenine, hypoxanthine, creatine, methionine, phytosphingosine and phenylalanine were reversed to the control level in FLP-treated group and six biomarkers like 2,8-dihydroxyadenine, indole-3-carboxylic acid, 3-methyldioxyindole, ethyl-N₂-acetyl-l-argininate, 3-O-methyldopa and xanthurenic acid were reversed to high control group by FLP, which indicates that the urinary metabolic pattern significantly changed after FLP treatment. CONCLUSIONS: Our study indicates that FLP treatment can ameliorate CKD by intervening in some dominating metabolic pathways, such as adenine metabolism and amino acid metabolism. The metabonomic results not only supplied a systematic view of the development and progression of CKD and mechanism studies of FLP but also provided the theoretical basis for the prevention or treatment of CKD. Poria cocos Wolf (Polyporaceae) is a well-known medicinal fungus. The epidermis of the sclerotia (“Fu-Ling-Pi” in Chinese) is used as a diuretic and traditionally used for promoting urination and reduce edema. Traditional Chinese medicines (TCM) treat many diseases through multi-components, multi-ways and multi-targets. However, the molecular mechanisms of TCM are not yet well understood. In the present work, ultra performance liquid chromatography-based metabonomics analysis was applied to investigate the urinary metabolite profiling of the renoprotective effect of FLP on adenine-induced chronic kidney disease (CKD) rat model and involved possible mechanism. A metabonomic approach based on ultra performance liquid chromatography coupled with quadrupole time-of-flight high-sensitivity mass spectrometry and a novel mass spectrometryElevated Energy data collection technique was developed. The resulting dataset was analyzed by principal component analysis and partial least squares discriminant analysis. The identification of all potential biomarkers was performed using reference standard by comparing their mass spectra, MSE fragments information, isotopic pattern and MassLynx i-FIT algorithm. By partial least squares-discriminate analysis, 15 biomarkers in rat urine were identified and 11 of them were related to the pathway of adenine metabolism and amino acid metabolism. Among these biomarkers, eight biomarkers like adenine, l-acetylcarnitine, 8-hydroxyadenine, hypoxanthine, creatine, methionine, phytosphingosine and phenylalanine were reversed to the control level in FLP-treated group and six biomarkers like 2,8-dihydroxyadenine, indole-3-carboxylic acid, 3-methyldioxyindole, ethyl-N2-acetyl-l-argininate, 3-O-methyldopa and xanthurenic acid were reversed to high control group by FLP, which indicates that the urinary metabolic pattern significantly changed after FLP treatment. Our study indicates that FLP treatment can ameliorate CKD by intervening in some dominating metabolic pathways, such as adenine metabolism and amino acid metabolism. The metabonomic results not only supplied a systematic view of the development and progression of CKD and mechanism studies of FLP but also provided the theoretical basis for the prevention or treatment of CKD. [Display omitted] Poria cocos Wolf (Polyporaceae) is a well-known medicinal fungus. The epidermis of the sclerotia ("Fu-Ling-Pi" in Chinese) is used as a diuretic and traditionally used for promoting urination and reduce edema.ETHNOPHARMACOLOGICAL RELEVANCEPoria cocos Wolf (Polyporaceae) is a well-known medicinal fungus. The epidermis of the sclerotia ("Fu-Ling-Pi" in Chinese) is used as a diuretic and traditionally used for promoting urination and reduce edema.Traditional Chinese medicines (TCM) treat many diseases through multi-components, multi-ways and multi-targets. However, the molecular mechanisms of TCM are not yet well understood. In the present work, ultra performance liquid chromatography-based metabonomics analysis was applied to investigate the urinary metabolite profiling of the renoprotective effect of FLP on adenine-induced chronic kidney disease (CKD) rat model and involved possible mechanism.AIM OF THE STUDYTraditional Chinese medicines (TCM) treat many diseases through multi-components, multi-ways and multi-targets. However, the molecular mechanisms of TCM are not yet well understood. In the present work, ultra performance liquid chromatography-based metabonomics analysis was applied to investigate the urinary metabolite profiling of the renoprotective effect of FLP on adenine-induced chronic kidney disease (CKD) rat model and involved possible mechanism.A metabonomic approach based on ultra performance liquid chromatography coupled with quadrupole time-of-flight high-sensitivity mass spectrometry and a novel mass spectrometry(Elevated Energy) data collection technique was developed. The resulting dataset was analyzed by principal component analysis and partial least squares discriminant analysis. The identification of all potential biomarkers was performed using reference standard by comparing their mass spectra, MS(E) fragments information, isotopic pattern and MassLynx i-FIT algorithm.MATERIAL AND METHODSA metabonomic approach based on ultra performance liquid chromatography coupled with quadrupole time-of-flight high-sensitivity mass spectrometry and a novel mass spectrometry(Elevated Energy) data collection technique was developed. The resulting dataset was analyzed by principal component analysis and partial least squares discriminant analysis. The identification of all potential biomarkers was performed using reference standard by comparing their mass spectra, MS(E) fragments information, isotopic pattern and MassLynx i-FIT algorithm.By partial least squares-discriminate analysis, 15 biomarkers in rat urine were identified and 11 of them were related to the pathway of adenine metabolism and amino acid metabolism. Among these biomarkers, eight biomarkers like adenine, L-acetylcarnitine, 8-hydroxyadenine, hypoxanthine, creatine, methionine, phytosphingosine and phenylalanine were reversed to the control level in FLP-treated group and six biomarkers like 2,8-dihydroxyadenine, indole-3-carboxylic acid, 3-methyldioxyindole, ethyl-N2-acetyl-L-argininate, 3-O-methyldopa and xanthurenic acid were reversed to high control group by FLP, which indicates that the urinary metabolic pattern significantly changed after FLP treatment.RESULTSBy partial least squares-discriminate analysis, 15 biomarkers in rat urine were identified and 11 of them were related to the pathway of adenine metabolism and amino acid metabolism. Among these biomarkers, eight biomarkers like adenine, L-acetylcarnitine, 8-hydroxyadenine, hypoxanthine, creatine, methionine, phytosphingosine and phenylalanine were reversed to the control level in FLP-treated group and six biomarkers like 2,8-dihydroxyadenine, indole-3-carboxylic acid, 3-methyldioxyindole, ethyl-N2-acetyl-L-argininate, 3-O-methyldopa and xanthurenic acid were reversed to high control group by FLP, which indicates that the urinary metabolic pattern significantly changed after FLP treatment.Our study indicates that FLP treatment can ameliorate CKD by intervening in some dominating metabolic pathways, such as adenine metabolism and amino acid metabolism. The metabonomic results not only supplied a systematic view of the development and progression of CKD and mechanism studies of FLP but also provided the theoretical basis for the prevention or treatment of CKD.CONCLUSIONSOur study indicates that FLP treatment can ameliorate CKD by intervening in some dominating metabolic pathways, such as adenine metabolism and amino acid metabolism. The metabonomic results not only supplied a systematic view of the development and progression of CKD and mechanism studies of FLP but also provided the theoretical basis for the prevention or treatment of CKD. |
| Author | Zhao, Ying-Yong Lin, Rui-Chao Li, Hai-Tao Feng, Ya-Long Bai, Xu |
| Author_xml | – sequence: 1 givenname: Ying-Yong surname: Zhao fullname: Zhao, Ying-Yong email: zyy@nwu.edu.cn, zhaoyybr@163.com organization: Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, No. 169 Changle West Road, Xi'an 710032, PR China – sequence: 2 givenname: Hai-Tao surname: Li fullname: Li, Hai-Tao organization: Department of Biomedical Engineering, the Fourth Military Medical University, Xi’an 710032, PR China – sequence: 3 givenname: Ya-Long surname: Feng fullname: Feng, Ya-Long organization: Department of Pharmacology, School of Pharmacy, the Fourth Military Medical University, No. 169 Changle West Road, Xi'an 710032, PR China – sequence: 4 givenname: Xu surname: Bai fullname: Bai, Xu organization: Solution centrer, Waters Technologies (Shanghai) Ltd., No. 1387 Zhangdong Road, Shanghai 201203, PR China – sequence: 5 givenname: Rui-Chao surname: Lin fullname: Lin, Rui-Chao email: linrch307@sina.com organization: National Institutes for Food and Drug Control, State Food and Drug Administration, No. 2 Tiantan Xili, Beijing 100050, PR China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23612421$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkkFrFDEYhoNU7Lb6A7xojl52zZdkJjN4kmKrUFDQPYdM5ovNMpOsSaa4_94sWz14aCHwQXje94M8uSBnIQYk5DWwDTBo3-82O9xvOAOxYXLDoHtGVtApvlaNEmdkxYTq1p2ScE4uct4xxhRI9oKcc9EClxxW5Pc2-WDSgc5YzBBDnL2luSzjgUZHyx3SvCRnLNLJHDAdL7_F5A210cZMTT2BonNoi79HWhKaMmMo1MVE7V2KofYlDGaiPuyWusgHmkzJL8lzZ6aMrx7mJdlef_px9Xl9-_Xmy9XH27VtWF_WY9M7YNayhkkm296NvG2V6AcQjjsurJUOBtchIONDY3tr-0GgHJSS3cCZuCTvTr37FH8tmIuefbY4TSZgXLKGhktopFLt06jseQei7fqnUaGAK2BcVvTNA7oMM456n_xcH1z_dVABOAE2xZwTun8IMH30rHe6etZHz5pJXT3XjPovY30xxcdQkvHTo8m3p6QzUZufyWe9_V4BWX-H7ETbVOLDicCq5d5j0tl6DBZHn6pmPUb_SP8fvCPK2g |
| CitedBy_id | crossref_primary_10_1016_j_clinbiochem_2017_09_012 crossref_primary_10_1002_med_21596 crossref_primary_10_1016_j_cbi_2017_05_020 crossref_primary_10_1016_j_ejmech_2019_06_091 crossref_primary_10_1016_S1875_5364_16_30067_X crossref_primary_10_1016_j_biopha_2018_03_134 crossref_primary_10_1016_j_biopha_2017_08_115 crossref_primary_10_2174_1389200220666181231124439 crossref_primary_10_1016_j_cvsm_2015_02_009 crossref_primary_10_1016_j_freeradbiomed_2019_01_046 crossref_primary_10_1038_s41401_024_01404_7 crossref_primary_10_1080_13880209_2018_1435697 crossref_primary_10_1155_2017_2012585 crossref_primary_10_1016_j_jep_2021_114189 crossref_primary_10_3389_fphar_2016_00307 crossref_primary_10_1038_srep14472 crossref_primary_10_1039_C7RA08519B crossref_primary_10_1111_bph_14333 crossref_primary_10_1016_j_jep_2013_10_043 crossref_primary_10_1177_2040622319869116 crossref_primary_10_3390_genes14030710 crossref_primary_10_3389_fmicb_2021_695155 crossref_primary_10_1038_s41598_018_32115_9 crossref_primary_10_1186_s12967_019_2054_5 crossref_primary_10_1038_s41598_017_03249_z crossref_primary_10_1007_s00018_019_03155_9 crossref_primary_10_1016_j_jep_2017_09_003 crossref_primary_10_1080_21553769_2017_1279573 crossref_primary_10_1155_2017_6359730 crossref_primary_10_3389_fphar_2022_860588 crossref_primary_10_1002_mnfr_201900132 crossref_primary_10_1039_C6RA28595C crossref_primary_10_1002_bmc_4332 crossref_primary_10_1016_j_biopha_2019_108990 crossref_primary_10_1016_j_jchromb_2018_10_011 crossref_primary_10_3389_fphar_2021_719880 crossref_primary_10_1016_j_chemosphere_2017_03_129 crossref_primary_10_1016_j_clinbiochem_2014_07_019 crossref_primary_10_1038_srep15592 crossref_primary_10_1002_jssc_201500982 crossref_primary_10_1021_acs_jafc_5b05350 crossref_primary_10_1016_j_aqrep_2021_100632 crossref_primary_10_1016_j_abb_2015_07_018 crossref_primary_10_1016_j_phymed_2018_09_182 crossref_primary_10_1080_13880209_2017_1281969 crossref_primary_10_1155_2017_1480514 crossref_primary_10_1016_j_jep_2017_07_003 crossref_primary_10_4155_bio_14_309 crossref_primary_10_1038_srep22151 crossref_primary_10_3390_molecules24071331 crossref_primary_10_1590_1414_431x2024e14249 crossref_primary_10_1007_s40005_023_00658_3 crossref_primary_10_1016_j_jchromb_2016_05_019 crossref_primary_10_1016_j_jep_2013_11_031 crossref_primary_10_1155_2014_913687 crossref_primary_10_1039_C5AY00023H crossref_primary_10_1155_2020_6408202 crossref_primary_10_1016_j_cca_2019_08_030 crossref_primary_10_3109_13880209_2016_1168853 crossref_primary_10_1016_j_cbi_2018_07_008 crossref_primary_10_1016_j_jpba_2016_02_035 crossref_primary_10_1038_s41467_019_09329_0 crossref_primary_10_1155_2020_2716325 crossref_primary_10_3389_fphar_2020_505249 crossref_primary_10_1021_acs_jafc_8b00099 crossref_primary_10_1186_s13020_024_01004_x crossref_primary_10_1016_j_phymed_2017_10_008 crossref_primary_10_1002_cbdv_201900363 crossref_primary_10_1007_s11274_019_2602_4 crossref_primary_10_1155_2014_184162 crossref_primary_10_1371_journal_pone_0115467 crossref_primary_10_1016_j_phymed_2019_152913 crossref_primary_10_1016_j_cbi_2017_12_008 crossref_primary_10_1016_j_phymed_2020_153323 crossref_primary_10_1590_1806_9061_2017_0466 crossref_primary_10_1016_j_biopha_2018_02_127 crossref_primary_10_1016_j_cbi_2014_02_014 crossref_primary_10_3389_fphar_2020_01237 crossref_primary_10_1016_j_cbi_2017_06_011 crossref_primary_10_1016_j_freeradbiomed_2019_06_012 crossref_primary_10_1016_j_jchromb_2015_10_014 crossref_primary_10_1080_10408444_2019_1635987 crossref_primary_10_1002_bmc_3829 crossref_primary_10_1016_j_cbi_2015_09_005 crossref_primary_10_1038_s41467_020_19444_y crossref_primary_10_1039_C4RA10539G crossref_primary_10_2217_bmm_14_81 crossref_primary_10_1016_j_jep_2017_03_040 crossref_primary_10_1002_ctd2_233 |
| Cites_doi | 10.1002/ptr.1097 10.1016/j.carres.2003.10.006 10.1016/j.ddtec.2004.10.011 10.1055/s-0030-1270823 10.1053/j.ajkd.2005.10.006 10.1097/01.mnh.0000185982.10201.a7 10.1021/pr050404w 10.1007/s11306-008-0110-x 10.1016/j.procbio.2012.07.008 10.1016/j.cca.2011.12.014 10.1002/hlca.200800360 10.1093/jn/137.6.1539S 10.1159/000183992 10.1053/j.ackd.2011.02.005 10.1080/004982599238047 10.1002/ptr.1624 10.1016/0003-9861(57)90088-7 10.1080/10286020802133597 10.4155/bio.09.142 10.1016/0167-4889(88)90169-3 10.1093/bioinformatics/18.suppl_2.S241 10.1016/S0022-3476(82)80259-X 10.1016/0031-9422(95)00110-S 10.1016/j.jep.2012.09.033 10.1073/pnas.93.11.5307 10.1016/j.cca.2012.06.005 10.1016/j.jpba.2011.01.042 10.1002/9780470720301.ch12 10.1038/nrd728 10.1016/j.jchromb.2009.11.040 10.1016/j.fct.2004.01.018 10.1016/S1567-5769(03)00113-9 10.1055/s-0030-1250542 10.1021/np0780001 10.3109/1354750X.2012.724450 10.1016/S0031-9422(00)95099-4 10.1016/j.clinbiochem.2010.04.072 10.3109/1354750X.2011.637180 10.1021/pr3007792 10.1016/j.cbi.2012.12.002 10.1080/10286020701782742 |
| ContentType | Journal Article |
| Copyright | 2013 Elsevier Ireland Ltd. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
| Copyright_xml | – notice: 2013 Elsevier Ireland Ltd. – notice: Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
| DBID | FBQ AAYXX CITATION CGR CUY CVF ECM EIF NPM 7X8 7S9 L.6 |
| DOI | 10.1016/j.jep.2013.04.018 |
| DatabaseName | AGRIS CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | MEDLINE AGRICOLA MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: FBQ name: AGRIS url: http://www.fao.org/agris/Centre.asp?Menu_1ID=DB&Menu_2ID=DB1&Language=EN&Content=http://www.fao.org/agris/search?Language=EN sourceTypes: Publisher |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 1872-7573 |
| EndPage | 410 |
| ExternalDocumentID | 23612421 10_1016_j_jep_2013_04_018 US201400048365 S0378874113002717 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .~1 0R~ 1B1 1RT 1~. 1~5 4.4 457 4G. 5GY 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AATCM AAWTL AAXUO ABFNM ABFRF ABJNI ABMAC ABXDB ABYKQ ABZDS ACDAQ ACGFO ACGFS ACIUM ACRLP ADBBV ADEZE AEBSH AEFWE AEKER AENEX AFKWA AFTJW AFXIZ AGUBO AGYEJ AIEXJ AIKHN AITUG AJBFU AJOXV ALCLG ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ AXJTR BKOJK BLXMC CS3 DU5 EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FIRID FNPLU FYGXN G-Q GBLVA IHE J1W KOM M34 M41 MO0 N9A O-L O9- OAUVE OGGZJ OZT P-8 P-9 P2P PC. Q38 RIG ROL RPZ SCC SDF SDG SDP SES SPCBC SPT SSP SSZ T5K TN5 ~G- ~KM .GJ 29K 53G AAQXK ABPIF ABPTK ADMUD AGHFR AHHHB ASPBG AVWKF AZFZN D-I FBQ FEDTE FGOYB G-2 HMT HVGLF HX~ HZ~ NCXOZ R2- SEW WUQ ZGI AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACRPL ACVFH ADCNI ADNMO ADVLN AEIPS AEUPX AFJKZ AFPUW AGCQF AGQPQ AGRNS AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP BNPGV CITATION SSH CGR CUY CVF ECM EIF NPM 7X8 EFKBS 7S9 L.6 |
| ID | FETCH-LOGICAL-c509t-d59f10cc05040469fd266739b13f2f23cc4f1bf8e1e02b5c9cc9b3e4b7748b203 |
| IEDL.DBID | .~1 |
| ISSN | 0378-8741 1872-7573 |
| IngestDate | Thu Jul 10 21:07:37 EDT 2025 Mon Jul 21 11:31:20 EDT 2025 Fri Jul 11 02:10:19 EDT 2025 Thu Apr 03 06:56:58 EDT 2025 Tue Jul 01 01:35:19 EDT 2025 Thu Apr 24 23:08:47 EDT 2025 Wed Dec 27 19:25:11 EST 2023 Fri Feb 23 02:23:15 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Ultra performance liquid chromatography Poria cocos PLS-DA Chronic kidney disease Mass spectrometryElevated Energy FLP PCA CRF Metabonomics BPI CKD UPLC Q-TOF/HSMS MSE TCM |
| Language | English |
| License | Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c509t-d59f10cc05040469fd266739b13f2f23cc4f1bf8e1e02b5c9cc9b3e4b7748b203 |
| Notes | http://dx.doi.org/10.1016/j.jep.2013.04.018 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| PMID | 23612421 |
| PQID | 1371271024 |
| PQPubID | 23479 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_1524154776 proquest_miscellaneous_1492813689 proquest_miscellaneous_1371271024 pubmed_primary_23612421 crossref_primary_10_1016_j_jep_2013_04_018 crossref_citationtrail_10_1016_j_jep_2013_04_018 fao_agris_US201400048365 elsevier_sciencedirect_doi_10_1016_j_jep_2013_04_018 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2013-07-09 |
| PublicationDateYYYYMMDD | 2013-07-09 |
| PublicationDate_xml | – month: 07 year: 2013 text: 2013-07-09 day: 09 |
| PublicationDecade | 2010 |
| PublicationPlace | Ireland |
| PublicationPlace_xml | – name: Ireland |
| PublicationTitle | Journal of ethnopharmacology |
| PublicationTitleAlternate | J Ethnopharmacol |
| PublicationYear | 2013 |
| Publisher | Elsevier Ireland Ltd |
| Publisher_xml | – name: Elsevier Ireland Ltd |
| References | Wang, Sun, Zhang, Sun, Wang, Wang (bib27) 2011; 55 Siu, Leung, Tong, Kwan (bib21) 2006; 47 Tai, Akahori, Shingu (bib22) 1993; 32 Chen, Chang (bib6) 2004; 42 Chen, Su, Zhao, Jiang, Liu, Cheng, Lai, Liu, Jia (bib5) 2006; 5 Zhao, Cheng, Wei, Bai, Lin (bib33) 2012; 17 Zhao, Shen, Cheng, Wei, Bai, Lin (bib38) 2012; 47 Anonymous (bib2) 2003 Zheng, Yang (bib42) 2008; 10 Lee, Jeon (bib14) 2003; 3 The State Pharmacopoeia Commission of PR China (bib25) 2010; vol. 1 Nicholson, Connelly, Lindon, Holmes (bib18) 2002; 1 Akihisa, Nakamura, Tokuda, Uchiyama, Suzuki, Kimura, Uchikura, Nishino (bib1) 2007; 70 Li, Liu, Li, Li, Chen, Bi, He (bib15) 2010; 43 Griffin (bib10) 2004; 1 Engle, Stockelman, Chen, Boivin, Yum, Davies, Ying, Sahota, Simmonds, Stambrook, Tischfield (bib8) 1996; 93 Nicholson, Lindon, Holmes (bib17) 1999; 29 Zhao, Cheng, Wei, Bai, Tan, Lin, Mei (bib39) 2013; 12 Taylor, King, Altmann, Fiehn (bib24) 2002; 2 Wang, Zhang, Ruan, Shashkov, Kilcoyne, Savage, Zhang (bib28) 2004; 339 Yang, Zhang, Liu, Zhang, Liu (bib30) 2009; 92 Zhao, Liu, Cheng, Bai, Lin (bib37) 2012; 413 De Vries, A., Sperling, O., 1977. Implications of disorders of purine metabolism for the kidney and the urinary tract. Ciba Foundation symposium 48, 179–206. Wang, Lamers, Korthout, van Nesselrooij, Witkamp, van der Heijden, Voshol, Havekes, Verpoorte, van der Greef (bib26) 2005; 19 Jia, Chen, Yin, Lu, Xu (bib12) 2008; 4 Zhao, Cheng, Wei, Bai, Lin (bib34) 2012; 413 Fernstrom, Fernstrom (bib9) 2007; 137 Zhao, Cheng, Wei, Xiao, Sun, Zhang, Lin (bib35) 2012; 17 Masera, Jankovic, Grazia (bib16) 1982; 100 Yokozawa, Zheng, Oura, Koizumi (bib31) 1986; 44 Boudonck, Rose, Karoly, Lee, Lawton, Lapinskas (bib4) 2009; 1 Janjua, Mahan (bib11) 2011; 18 Arduini, Mezzetti, Porreca, Lapenna, DeJulia, Marzio, Polidoro, Cuccurullo (bib3) 1988; 970 Tai, Shingu, Kikuchi, Tezuka, Akahor (bib23) 1995; 39 Kaori, Yoshiharu, Ryoko, Atsuko, Kenjiro, Toshimitsu (bib13) 2010; 878 Zheng, Yang (bib41) 2008; 10 Zoccali (bib43) 2005; 14 Wyngaarden, Dunn (bib29) 1957; 70 Zhang, Sun, Wang, Sun, Wang, Wang (bib32) 2010; 76 Zhao, Feng, Du, Xi, Cheng, Wei (bib36) 2012; 144 Zhao, Zhang, Long, Cheng, Bai, Wei, Lin (bib40) 2013; 301 Sekiya, Goto, Shimada, Endo, Sakakibara, Terasawa (bib20) 2003; 17 Ríos (bib19) 2011; 77 Yang (10.1016/j.jep.2013.04.018_bib30) 2009; 92 Anonymous (10.1016/j.jep.2013.04.018_bib2) 2003 Kaori (10.1016/j.jep.2013.04.018_bib13) 2010; 878 Li (10.1016/j.jep.2013.04.018_bib15) 2010; 43 Tai (10.1016/j.jep.2013.04.018_bib23) 1995; 39 Janjua (10.1016/j.jep.2013.04.018_bib11) 2011; 18 Griffin (10.1016/j.jep.2013.04.018_bib10) 2004; 1 Boudonck (10.1016/j.jep.2013.04.018_bib4) 2009; 1 Zhang (10.1016/j.jep.2013.04.018_bib32) 2010; 76 Zhao (10.1016/j.jep.2013.04.018_bib39) 2013; 12 Zhao (10.1016/j.jep.2013.04.018_bib40) 2013; 301 10.1016/j.jep.2013.04.018_bib7 The State Pharmacopoeia Commission of PR China (10.1016/j.jep.2013.04.018_bib25) 2010; vol. 1 Lee (10.1016/j.jep.2013.04.018_bib14) 2003; 3 Sekiya (10.1016/j.jep.2013.04.018_bib20) 2003; 17 Chen (10.1016/j.jep.2013.04.018_bib6) 2004; 42 Zhao (10.1016/j.jep.2013.04.018_bib36) 2012; 144 Zheng (10.1016/j.jep.2013.04.018_bib42) 2008; 10 Wang (10.1016/j.jep.2013.04.018_bib28) 2004; 339 Yokozawa (10.1016/j.jep.2013.04.018_bib31) 1986; 44 Zhao (10.1016/j.jep.2013.04.018_bib34) 2012; 413 Jia (10.1016/j.jep.2013.04.018_bib12) 2008; 4 Nicholson (10.1016/j.jep.2013.04.018_bib17) 1999; 29 Siu (10.1016/j.jep.2013.04.018_bib21) 2006; 47 Fernstrom (10.1016/j.jep.2013.04.018_bib9) 2007; 137 Zhao (10.1016/j.jep.2013.04.018_bib38) 2012; 47 Akihisa (10.1016/j.jep.2013.04.018_bib1) 2007; 70 Zhao (10.1016/j.jep.2013.04.018_bib37) 2012; 413 Arduini (10.1016/j.jep.2013.04.018_bib3) 1988; 970 Engle (10.1016/j.jep.2013.04.018_bib8) 1996; 93 Ríos (10.1016/j.jep.2013.04.018_bib19) 2011; 77 Taylor (10.1016/j.jep.2013.04.018_bib24) 2002; 2 Tai (10.1016/j.jep.2013.04.018_bib22) 1993; 32 Zhao (10.1016/j.jep.2013.04.018_bib35) 2012; 17 Zheng (10.1016/j.jep.2013.04.018_bib41) 2008; 10 Masera (10.1016/j.jep.2013.04.018_bib16) 1982; 100 Wang (10.1016/j.jep.2013.04.018_bib26) 2005; 19 Wyngaarden (10.1016/j.jep.2013.04.018_bib29) 1957; 70 Zoccali (10.1016/j.jep.2013.04.018_bib43) 2005; 14 Zhao (10.1016/j.jep.2013.04.018_bib33) 2012; 17 Chen (10.1016/j.jep.2013.04.018_bib5) 2006; 5 Wang (10.1016/j.jep.2013.04.018_bib27) 2011; 55 Nicholson (10.1016/j.jep.2013.04.018_bib18) 2002; 1 |
| References_xml | – volume: 39 start-page: 1165 year: 1995 end-page: 1169 ident: bib23 article-title: Triterpenes from the surface layer of publication-title: Phytochemistry – volume: 10 start-page: 289 year: 2008 end-page: 292 ident: bib41 article-title: Two new lanostane triterpenoids from publication-title: Journal of Asian Natural Products Research – volume: 32 start-page: 1239 year: 1993 end-page: 1244 ident: bib22 article-title: Triterpenes of publication-title: Phytochemistry – volume: 17 start-page: 721 year: 2012 end-page: 729 ident: bib33 article-title: Application of faecal metabonomics on an experimental model of tubulointerstitial fibrosis by ultra performance liquid chromatography/high-sensitivity mass spectrometry with MS publication-title: Biomarkers – volume: 10 start-page: 640 year: 2008 end-page: 646 ident: bib42 article-title: Poriacosones A and B: two new lanostane triterpenoids from publication-title: Journal of Asian Natural Products Research – volume: 2 start-page: 241 year: 2002 end-page: 248 ident: bib24 article-title: Application of metabolomics to plant genotype discrimination using statistics and machine learning publication-title: Bioinformatics – volume: 42 start-page: 759 year: 2004 end-page: 769 ident: bib6 article-title: Antiproliferative and differentiating effects of polysaccharide fraction from fu-ling ( publication-title: Food and Chemical Toxicology – volume: 413 start-page: 642 year: 2012 end-page: 649 ident: bib37 article-title: Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS publication-title: Clinica Chimica Acta – start-page: 2003 year: 2003 ident: bib2 article-title: The Inner Canon of Emperor Huang – volume: 1 start-page: 1645 year: 2009 end-page: 1663 ident: bib4 article-title: Metabolomics for early detection of drug-induced kidney injury: review of the current status publication-title: Bioanalysis – volume: vol. 1 start-page: 224 year: 2010 end-page: 225 ident: bib25 publication-title: Pharmacopoeia of the People's Republic of China – volume: 301 start-page: 31 year: 2013 end-page: 38 ident: bib40 article-title: UPLC-Q-TOF/HSMS/MS publication-title: Chemico-Biological Interactions – volume: 970 start-page: 113 year: 1988 end-page: 121 ident: bib3 article-title: Effect of ischemia and reperfusion on antioxidant enzymes and mitochondrial inner membrane proteins in perfused rat heart publication-title: Biochimica et Biophysica Acta – volume: 76 start-page: 2026 year: 2010 end-page: 2035 ident: bib32 article-title: Metabolomics: towards understanding traditional Chinese medicine publication-title: Planta Medica – volume: 55 start-page: 859 year: 2011 end-page: 868 ident: bib27 article-title: Potential role of metabolomics approaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine publication-title: Journal of Pharmaceutical and Biomedical Analysis – volume: 17 start-page: 160 year: 2003 end-page: 162 ident: bib20 article-title: Inhibitory effects of triterpenes isolated from hoelen on free radical-induced lysis of red blood cells publication-title: Phytotherapy Research – volume: 70 start-page: 150 year: 1957 end-page: 156 ident: bib29 article-title: 8-hydroxyadenine as the metabolic intermediate in the oxidation of adenine to 2,8-dihydroxyadenine by xanthine oxidase publication-title: Archives of Biochemistry and Biophysics – volume: 100 start-page: 152 year: 1982 end-page: 155 ident: bib16 article-title: Urate-oxidase prophylaxis of uric acid-induced renal damage in childhood leukemia publication-title: Journal of Pediatrics – volume: 144 start-page: 775 year: 2012 end-page: 778 ident: bib36 article-title: Diuretic activity the ethanol and aqueous extracts of the surface layer of publication-title: Journal of Ethnopharmacology – volume: 47 start-page: 51 year: 2006 end-page: 59 ident: bib21 article-title: Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level publication-title: American Journal of Kidney Diseases – volume: 3 start-page: 1353 year: 2003 end-page: 1362 ident: bib14 article-title: Polysaccharide isolated from publication-title: International Immunopharmacology – volume: 92 start-page: 660 year: 2009 end-page: 667 ident: bib30 article-title: Two new triterpenes from the surface layer of publication-title: Helvetica Chimica Acta – volume: 137 start-page: S1539 year: 2007 end-page: S1547 ident: bib9 article-title: Tyrosine, phenylalanine and catecholamine synthesis and function in brain publication-title: Journal of Nutrition – volume: 878 start-page: 1662 year: 2010 end-page: 1668 ident: bib13 article-title: Metabolomic analysis of uremic toxins by liquid chromatography/electrospray ionization-tandem mass spectrometry publication-title: Journal of Chromatography B – volume: 17 start-page: 48 year: 2012 end-page: 55 ident: bib35 article-title: Serum metabonomics study of adenine-induced chronic renal failure rat by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry publication-title: Biomarkers – volume: 70 start-page: 948 year: 2007 end-page: 953 ident: bib1 article-title: Triterpene acids from publication-title: Journal of Natural Products – volume: 1 start-page: 285 year: 2004 end-page: 293 ident: bib10 article-title: The potential of metabonomics in drug safety and toxicology publication-title: Drug Discovery Today: Technologies – volume: 1 start-page: 153 year: 2002 end-page: 161 ident: bib18 article-title: Metabonomics: a platform for studying drug toxicity and gene function publication-title: Nature Reviews Drug Discovery – reference: De Vries, A., Sperling, O., 1977. Implications of disorders of purine metabolism for the kidney and the urinary tract. Ciba Foundation symposium 48, 179–206. – volume: 47 start-page: 1980 year: 2012 end-page: 1987 ident: bib38 article-title: Urinary metabonomics study on the protective effects of ergosta-4,6,8(14),22-tetraen-3-one on chronic renal failure in rats using UPLC Q-TOF/MS and a novel MS publication-title: Process Biochemistry – volume: 18 start-page: 324 year: 2011 end-page: 331 ident: bib11 article-title: Growth in chronic kidney disease publication-title: Advances in Chronic Kidney Disease – volume: 77 start-page: 681 year: 2011 end-page: 691 ident: bib19 article-title: Chemical constituents and pharmacological properties of publication-title: Planta Medica – volume: 339 start-page: 327 year: 2004 end-page: 334 ident: bib28 article-title: Chemical components and molecular mass of six polysaccharides isolated from the sclerotium of publication-title: Carbohydrate Research – volume: 12 start-page: 692 year: 2013 end-page: 703 ident: bib39 article-title: Intrarenal metabolomic investigation of chronic kidney disease and its TGF-β1 mechanism in induced-adenine rats using UPLC Q-TOF/HSMS/MS publication-title: Journal of Proteome Research – volume: 14 start-page: 532 year: 2005 end-page: 537 ident: bib43 article-title: Biomarkers in chronic kidney disease: utility and issues towards better understanding publication-title: Current Opinion in Nephrology and Hypertension – volume: 4 start-page: 183 year: 2008 end-page: 189 ident: bib12 article-title: Serum metabonomics study of chronic renal failure by ultra performance liquid chromatography coupled with Q-TOF mass spectrometry publication-title: Metabolomics – volume: 44 start-page: 230 year: 1986 end-page: 234 ident: bib31 article-title: Animal model of adenine-induced chronic renal failure in rats publication-title: Nephron – volume: 43 start-page: 992 year: 2010 end-page: 997 ident: bib15 article-title: Plasma metabolic profiling of Alzheimer's disease by liquid chromatography/mass spectrometry publication-title: Clinical Biochemistry – volume: 19 start-page: 173 year: 2005 end-page: 182 ident: bib26 article-title: Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology publication-title: Phytotherapy Research – volume: 93 start-page: 5307 year: 1996 end-page: 5312 ident: bib8 article-title: Adenine phosphoribosyltransferase-deficientmice develop 2,8-dihydroxyadenine nephrolithiasis publication-title: Proceedings of the National Academy of Sciences – volume: 413 start-page: 1438 year: 2012 end-page: 1445 ident: bib34 article-title: Effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) on adenine-induced chronic renal failure rat: a serum metabonomics study based on ultra performance liquid chromatography/high-sensitivity mass spectrometry coupled with MassLynx publication-title: Clinica Chimica Acta – volume: 29 start-page: 1181 year: 1999 end-page: 1189 ident: bib17 article-title: “Metabonomics”: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data publication-title: Xenobiotica – volume: 5 start-page: 995 year: 2006 end-page: 1002 ident: bib5 article-title: Metabonomic study of aristolochic acid-induced nephrotoxicity in rats publication-title: Journal of Proteome Research – start-page: 2003 year: 2003 ident: 10.1016/j.jep.2013.04.018_bib2 – volume: 17 start-page: 160 year: 2003 ident: 10.1016/j.jep.2013.04.018_bib20 article-title: Inhibitory effects of triterpenes isolated from hoelen on free radical-induced lysis of red blood cells publication-title: Phytotherapy Research doi: 10.1002/ptr.1097 – volume: 339 start-page: 327 year: 2004 ident: 10.1016/j.jep.2013.04.018_bib28 article-title: Chemical components and molecular mass of six polysaccharides isolated from the sclerotium of Poria cocos publication-title: Carbohydrate Research doi: 10.1016/j.carres.2003.10.006 – volume: 1 start-page: 285 year: 2004 ident: 10.1016/j.jep.2013.04.018_bib10 article-title: The potential of metabonomics in drug safety and toxicology publication-title: Drug Discovery Today: Technologies doi: 10.1016/j.ddtec.2004.10.011 – volume: 77 start-page: 681 year: 2011 ident: 10.1016/j.jep.2013.04.018_bib19 article-title: Chemical constituents and pharmacological properties of Poria cocos publication-title: Planta Medica doi: 10.1055/s-0030-1270823 – volume: 47 start-page: 51 year: 2006 ident: 10.1016/j.jep.2013.04.018_bib21 article-title: Use of allopurinol in slowing the progression of renal disease through its ability to lower serum uric acid level publication-title: American Journal of Kidney Diseases doi: 10.1053/j.ajkd.2005.10.006 – volume: 14 start-page: 532 year: 2005 ident: 10.1016/j.jep.2013.04.018_bib43 article-title: Biomarkers in chronic kidney disease: utility and issues towards better understanding publication-title: Current Opinion in Nephrology and Hypertension doi: 10.1097/01.mnh.0000185982.10201.a7 – volume: 5 start-page: 995 year: 2006 ident: 10.1016/j.jep.2013.04.018_bib5 article-title: Metabonomic study of aristolochic acid-induced nephrotoxicity in rats publication-title: Journal of Proteome Research doi: 10.1021/pr050404w – volume: 4 start-page: 183 year: 2008 ident: 10.1016/j.jep.2013.04.018_bib12 article-title: Serum metabonomics study of chronic renal failure by ultra performance liquid chromatography coupled with Q-TOF mass spectrometry publication-title: Metabolomics doi: 10.1007/s11306-008-0110-x – volume: 47 start-page: 1980 year: 2012 ident: 10.1016/j.jep.2013.04.018_bib38 article-title: Urinary metabonomics study on the protective effects of ergosta-4,6,8(14),22-tetraen-3-one on chronic renal failure in rats using UPLC Q-TOF/MS and a novel MSE data collection technique publication-title: Process Biochemistry doi: 10.1016/j.procbio.2012.07.008 – volume: 413 start-page: 642 year: 2012 ident: 10.1016/j.jep.2013.04.018_bib37 article-title: Urinary metabonomics study on biochemical changes in an experimental model of chronic renal failure by adenine based on UPLC Q-TOF/MS publication-title: Clinica Chimica Acta doi: 10.1016/j.cca.2011.12.014 – volume: vol. 1 start-page: 224 year: 2010 ident: 10.1016/j.jep.2013.04.018_bib25 – volume: 92 start-page: 660 year: 2009 ident: 10.1016/j.jep.2013.04.018_bib30 article-title: Two new triterpenes from the surface layer of Poria cocos publication-title: Helvetica Chimica Acta doi: 10.1002/hlca.200800360 – volume: 137 start-page: S1539 year: 2007 ident: 10.1016/j.jep.2013.04.018_bib9 article-title: Tyrosine, phenylalanine and catecholamine synthesis and function in brain publication-title: Journal of Nutrition doi: 10.1093/jn/137.6.1539S – volume: 44 start-page: 230 year: 1986 ident: 10.1016/j.jep.2013.04.018_bib31 article-title: Animal model of adenine-induced chronic renal failure in rats publication-title: Nephron doi: 10.1159/000183992 – volume: 18 start-page: 324 year: 2011 ident: 10.1016/j.jep.2013.04.018_bib11 article-title: Growth in chronic kidney disease publication-title: Advances in Chronic Kidney Disease doi: 10.1053/j.ackd.2011.02.005 – volume: 29 start-page: 1181 year: 1999 ident: 10.1016/j.jep.2013.04.018_bib17 article-title: “Metabonomics”: understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data publication-title: Xenobiotica doi: 10.1080/004982599238047 – volume: 19 start-page: 173 year: 2005 ident: 10.1016/j.jep.2013.04.018_bib26 article-title: Metabolomics in the context of systems biology: bridging traditional Chinese medicine and molecular pharmacology publication-title: Phytotherapy Research doi: 10.1002/ptr.1624 – volume: 70 start-page: 150 year: 1957 ident: 10.1016/j.jep.2013.04.018_bib29 article-title: 8-hydroxyadenine as the metabolic intermediate in the oxidation of adenine to 2,8-dihydroxyadenine by xanthine oxidase publication-title: Archives of Biochemistry and Biophysics doi: 10.1016/0003-9861(57)90088-7 – volume: 10 start-page: 640 year: 2008 ident: 10.1016/j.jep.2013.04.018_bib42 article-title: Poriacosones A and B: two new lanostane triterpenoids from Poria cocos publication-title: Journal of Asian Natural Products Research doi: 10.1080/10286020802133597 – volume: 1 start-page: 1645 year: 2009 ident: 10.1016/j.jep.2013.04.018_bib4 article-title: Metabolomics for early detection of drug-induced kidney injury: review of the current status publication-title: Bioanalysis doi: 10.4155/bio.09.142 – volume: 970 start-page: 113 year: 1988 ident: 10.1016/j.jep.2013.04.018_bib3 article-title: Effect of ischemia and reperfusion on antioxidant enzymes and mitochondrial inner membrane proteins in perfused rat heart publication-title: Biochimica et Biophysica Acta doi: 10.1016/0167-4889(88)90169-3 – volume: 2 start-page: 241 year: 2002 ident: 10.1016/j.jep.2013.04.018_bib24 article-title: Application of metabolomics to plant genotype discrimination using statistics and machine learning publication-title: Bioinformatics doi: 10.1093/bioinformatics/18.suppl_2.S241 – volume: 100 start-page: 152 year: 1982 ident: 10.1016/j.jep.2013.04.018_bib16 article-title: Urate-oxidase prophylaxis of uric acid-induced renal damage in childhood leukemia publication-title: Journal of Pediatrics doi: 10.1016/S0022-3476(82)80259-X – volume: 39 start-page: 1165 year: 1995 ident: 10.1016/j.jep.2013.04.018_bib23 article-title: Triterpenes from the surface layer of Poria cocos publication-title: Phytochemistry doi: 10.1016/0031-9422(95)00110-S – volume: 144 start-page: 775 year: 2012 ident: 10.1016/j.jep.2013.04.018_bib36 article-title: Diuretic activity the ethanol and aqueous extracts of the surface layer of Poria cocos in rat publication-title: Journal of Ethnopharmacology doi: 10.1016/j.jep.2012.09.033 – volume: 93 start-page: 5307 year: 1996 ident: 10.1016/j.jep.2013.04.018_bib8 article-title: Adenine phosphoribosyltransferase-deficientmice develop 2,8-dihydroxyadenine nephrolithiasis publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.93.11.5307 – volume: 413 start-page: 1438 year: 2012 ident: 10.1016/j.jep.2013.04.018_bib34 article-title: Effect of ergosta-4,6,8(14),22-tetraen-3-one (ergone) on adenine-induced chronic renal failure rat: a serum metabonomics study based on ultra performance liquid chromatography/high-sensitivity mass spectrometry coupled with MassLynx i-FIT algorithm publication-title: Clinica Chimica Acta doi: 10.1016/j.cca.2012.06.005 – volume: 55 start-page: 859 year: 2011 ident: 10.1016/j.jep.2013.04.018_bib27 article-title: Potential role of metabolomics approaches in the area of traditional Chinese medicine: as pillars of the bridge between Chinese and Western medicine publication-title: Journal of Pharmaceutical and Biomedical Analysis doi: 10.1016/j.jpba.2011.01.042 – ident: 10.1016/j.jep.2013.04.018_bib7 doi: 10.1002/9780470720301.ch12 – volume: 1 start-page: 153 year: 2002 ident: 10.1016/j.jep.2013.04.018_bib18 article-title: Metabonomics: a platform for studying drug toxicity and gene function publication-title: Nature Reviews Drug Discovery doi: 10.1038/nrd728 – volume: 878 start-page: 1662 year: 2010 ident: 10.1016/j.jep.2013.04.018_bib13 article-title: Metabolomic analysis of uremic toxins by liquid chromatography/electrospray ionization-tandem mass spectrometry publication-title: Journal of Chromatography B doi: 10.1016/j.jchromb.2009.11.040 – volume: 42 start-page: 759 year: 2004 ident: 10.1016/j.jep.2013.04.018_bib6 article-title: Antiproliferative and differentiating effects of polysaccharide fraction from fu-ling (Poria cocos) on human leukemic U937 and HL-60 cells publication-title: Food and Chemical Toxicology doi: 10.1016/j.fct.2004.01.018 – volume: 3 start-page: 1353 year: 2003 ident: 10.1016/j.jep.2013.04.018_bib14 article-title: Polysaccharide isolated from Poria cocos sclerotium induces NF-jB/Rel activation and iNOS expression in murine macrophages publication-title: International Immunopharmacology doi: 10.1016/S1567-5769(03)00113-9 – volume: 76 start-page: 2026 year: 2010 ident: 10.1016/j.jep.2013.04.018_bib32 article-title: Metabolomics: towards understanding traditional Chinese medicine publication-title: Planta Medica doi: 10.1055/s-0030-1250542 – volume: 70 start-page: 948 year: 2007 ident: 10.1016/j.jep.2013.04.018_bib1 article-title: Triterpene acids from Poria cocos and their anti-tumor-promoting effects publication-title: Journal of Natural Products doi: 10.1021/np0780001 – volume: 17 start-page: 721 year: 2012 ident: 10.1016/j.jep.2013.04.018_bib33 article-title: Application of faecal metabonomics on an experimental model of tubulointerstitial fibrosis by ultra performance liquid chromatography/high-sensitivity mass spectrometry with MSE data collection technique publication-title: Biomarkers doi: 10.3109/1354750X.2012.724450 – volume: 32 start-page: 1239 year: 1993 ident: 10.1016/j.jep.2013.04.018_bib22 article-title: Triterpenes of Poria cocos publication-title: Phytochemistry doi: 10.1016/S0031-9422(00)95099-4 – volume: 43 start-page: 992 year: 2010 ident: 10.1016/j.jep.2013.04.018_bib15 article-title: Plasma metabolic profiling of Alzheimer's disease by liquid chromatography/mass spectrometry publication-title: Clinical Biochemistry doi: 10.1016/j.clinbiochem.2010.04.072 – volume: 17 start-page: 48 year: 2012 ident: 10.1016/j.jep.2013.04.018_bib35 article-title: Serum metabonomics study of adenine-induced chronic renal failure rat by ultra performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry publication-title: Biomarkers doi: 10.3109/1354750X.2011.637180 – volume: 12 start-page: 692 year: 2013 ident: 10.1016/j.jep.2013.04.018_bib39 article-title: Intrarenal metabolomic investigation of chronic kidney disease and its TGF-β1 mechanism in induced-adenine rats using UPLC Q-TOF/HSMS/MSE publication-title: Journal of Proteome Research doi: 10.1021/pr3007792 – volume: 301 start-page: 31 year: 2013 ident: 10.1016/j.jep.2013.04.018_bib40 article-title: UPLC-Q-TOF/HSMS/MSE-based metabonomics for adenine-induced changes in metabolic profiles of rat faeces and intervention effects of ergosta-4,6,8(14),22-tetraen-3-one publication-title: Chemico-Biological Interactions doi: 10.1016/j.cbi.2012.12.002 – volume: 10 start-page: 289 year: 2008 ident: 10.1016/j.jep.2013.04.018_bib41 article-title: Two new lanostane triterpenoids from Poria cocos publication-title: Journal of Asian Natural Products Research doi: 10.1080/10286020701782742 |
| SSID | ssj0007140 |
| Score | 2.4345016 |
| Snippet | Poria cocos Wolf (Polyporaceae) is a well-known medicinal fungus. The epidermis of the sclerotia (“Fu-Ling-Pi” in Chinese) is used as a diuretic and... ETHNOPHARMACOLOGICAL RELEVANCE: Poria cocos Wolf (Polyporaceae) is a well-known medicinal fungus. The epidermis of the sclerotia (“Fu-Ling-Pi” in Chinese) is... Poria cocos Wolf (Polyporaceae) is a well-known medicinal fungus. The epidermis of the sclerotia ("Fu-Ling-Pi" in Chinese) is used as a diuretic and... |
| SourceID | proquest pubmed crossref fao elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 403 |
| SubjectTerms | adenine Adenine - metabolism algorithms amino acid metabolism animal models Animals biochemical pathways biomarkers Biomarkers - metabolism Chromatography, High Pressure Liquid Chromatography, High Pressure Liquid - methods Chronic kidney disease Cocos creatine data collection discriminant analysis Diuretics Diuretics - pharmacology drug effects drug therapy Drugs, Chinese Herbal Drugs, Chinese Herbal - pharmacology edema Edema - drug therapy fungi hypoxanthine Kidney Kidney - drug effects Kidney - metabolism Kidney Failure, Chronic Kidney Failure, Chronic - drug therapy Kidney Failure, Chronic - metabolism Kidney Failure, Chronic - urine kidneys least squares Male mass spectrometry Mass spectrometryElevated Energy Medicine, Chinese Traditional Medicine, Chinese Traditional - methods metabolism Metabolomics Metabolomics - methods Metabonomics methionine methods pharmacology phenylalanine Plant Preparations Plant Preparations - pharmacology Poria Poria cocos principal component analysis Principal Component Analysis - methods Rats Rats, Sprague-Dawley renoprotective effect Ultra performance liquid chromatography Urination urine Wolfiporia Wolfiporia cocos xanthurenic acid |
| Title | Urinary metabonomic study of the surface layer of Poria cocos as an effective treatment for chronic renal injury in rats |
| URI | https://dx.doi.org/10.1016/j.jep.2013.04.018 https://www.ncbi.nlm.nih.gov/pubmed/23612421 https://www.proquest.com/docview/1371271024 https://www.proquest.com/docview/1492813689 https://www.proquest.com/docview/1524154776 |
| Volume | 148 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZpeuml9J3tI6hQcihR15IlP44hNGxbGhaShdyEJEtll8QO611oLvntmZHtXQrtHgoGgxmBpBmNPlkz3xDyCRCAt5XirAJ8y2RhLLNwDGHS5C4YUYTM4H_In-fZZCa_X6mrPXI65MJgWGXv-zufHr11_2Xcz-b4dj4fXyRIhQ4bIl7ICDiVYAa7zNHKv9xvwzzyLikShRlKDzebMcZr4ZGykqeR7RTrfvx9b3oUTPNvBBp3orNn5GkPIelJ18vnZM_XL8jRtOOgvjuml9uUqvaYHtHplp367iX5PVvGFFx641dgADErmUaSWdoECnCQtutlMM7TawNwHD9OG7BSCp6zaamBp6ZdFAg4SroJVKeAfqnrqHbp0mMP5_UCNAYvCmbWviKzs6-XpxPWl19gDlDEilWqDDxxLlGw0OEUHSqBNUJLy9Mggkidk4HbUHjuE2GVK50rbeqlBURZWJGkr8l-3dT-AOOnlJRe-grQjyxUZQA2hkI68K3cVIGPSDJMvHY9NzmWyLjWQxDaQoOuNOpKJ1KDrkbk86bJbUfMsUtYDtrUf1iXho1jV7MD0Lw2v8Df6tmFwNNo5ODP1Ih8HMxBw4LEWxZT-2bdap7mXCBukztkZCkKnmZFuUNGIbiSeZ6NyJvO3jYDRcYcvMt_-3_jekeeiFjVI2dJ-Z7sr5Zr_wGw1coexsVzSB6ffPsxOX8ADm8hoQ |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swEBdt-rC9jH03-9Rg9GHUxJIlfzyWspKubQg0gb4JSZZKQmeXOIH1v9-dbKcMtjwMDAZzAkl3Ov1k3f2OkK-AAJwpJYtKwLeRyLWJDBxDIqEz6zXPfarxP-TVJB3PxY8bebNHTvtcGAyr7Hx_69ODt-6-jLrZHN0vFqPrGKnQYUPECxkOp5J9coDsVHJADk7OL8aTrUPO2rxIlI-wQX-5GcK8lg5ZK1kSCE-x9Mfft6d9r-t_g9CwGZ09J886FElP2o6-IHuuekmOpi0N9cMxnT1mVTXH9IhOHwmqH16RX_NVyMKlP90abCAkJtPAM0trTwER0maz8to6eqcBkePHaQ2GSsF51g3V8FS0DQQBX0m3seoUADC1LdsuXTns4aJagtLgRcHSmtdkfvZ9djqOugoMkQUgsY5KWXgWWxtLWOtwkPYlxzKhhWGJ554n1grPjM8dczE30hbWFiZxwgCozA2PkzdkUNWVO8QQKimEE64EACRyWWpAjj4XFtwr06VnQxL3E69sR0-OVTLuVB-HtlSgK4W6UrFQoKsh-bZtct9yc-wSFr021R8GpmDv2NXsEDSv9C24XDW_5nggDTT8qRySL705KFiTeNGiK1dvGsWSjHGEbmKHjCh4zpI0L3bISMRXIsvSIXnb2tt2oEiag9f57_5vXJ_Jk_Hs6lJdnk8u3pOnPBT5yKK4-EAG69XGfQSotTafuqX0G-qcJFI |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Urinary+metabonomic+study+of+the+surface+layer+of+Poria+cocos+as+an+effective+treatment+for+chronic+renal+injury+in+rats&rft.jtitle=Journal+of+ethnopharmacology&rft.au=Zhao%2C+Ying-Yong&rft.au=Li%2C+Hai-Tao&rft.au=Feng%2C+Ya-Long&rft.au=Bai%2C+Xu&rft.date=2013-07-09&rft.issn=0378-8741&rft.volume=148&rft.issue=2+p.403-410&rft.spage=403&rft.epage=410&rft_id=info:doi/10.1016%2Fj.jep.2013.04.018&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0378-8741&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0378-8741&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0378-8741&client=summon |