Neural mechanism for hypothalamic-mediated autonomic responses to light during migraine

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 28; pp. E5683 - E5692
• Main Authors: Noseda, Rodrigo, Lee, Alice J., Nir, Rony-Reuven, Bernstein, Carolyn A., Kainz, Vanessa M., Bertisch, Suzanne M., Buettner, Catherine, Borsook, David, Burstein, Rami
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 11.07.2017
• Series: From the Cover
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anatomy; Animals; Autonomic nervous system; Autonomic Nervous System - physiology; Aversion; Axons; Biological Sciences; Brain; Brain stem; Case-Control Studies; Color; Dopamine; Emotions; Female; Headache; Histamine; Humans; Hypothalamus; Hypothalamus - physiology; Light; Light effects; Male; Melanin; Melanin-concentrating hormone; Middle Aged; Migraine; Migraine Disorders - physiopathology; Models, Neurological; Neurons; Neurons - physiology; Nuclei (cytology); Orexins; Oxytocin; Parasympathetic nervous system; Photophobia; PNAS Plus; Rats; Rats, Sprague-Dawley; Retina; Retina - physiology; Retinal ganglion cells; Rodents; Spinal cord; Sympathetic Nervous System - physiology; Vasopressin; Young Adult; emotions; parasympathetic; sympathetic; photophobia; colors

Migraineurs avoid light because it intensifies their headache. However, this is not the only reason for their aversion to light. Studying migraineurs and control subjects, we found that lights triggered more changes in autonomic functions and negative emotions during, rather than in the absence of,...