PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 45; pp. 11944 - 11949
• Main Authors: Wang, Huibing, Meng, Huyan, Li, Xingyan, Zhu, Kezhou, Dong, Kangyun, Mookhtiar, Adnan K., Wei, Huiting, Li, Ying, Sun, Shao-Cong, Yuan, Junying
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 07.11.2017
• Subjects: Activation; Apoptosis; Binding sites; Biological Sciences; c-FLIP protein; Caspase; Caspase-8; Cell death; Cells; Enzymes; FLIP protein; mRNA; Necroptosis; Ribonucleic acid; RNA; Rodents; Tumor necrosis factor-α; Ubiquitin; Ubiquitin-protein ligase; Ubiquitination; Peli1; apoptosis; ubiquitination; TNF; necroptosis

Apoptosis and necroptosis are two distinct cell death mechanisms that may be activated in cells on stimulation by TNFα. It is still unclear, however, how apoptosis and necroptosis may be differentially regulated. Here we screened for E3 ubiquitin ligases that could mediate necroptosis. We found that...