Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 115; no. 8; pp. 1697 - 1706
• Main Authors: Zhou, Xiaopu, Chen, Yu, Mok, Kin Y., Zhao, Qianhua, Chen, Keliang, Chen, Yuewen, Hardy, John, Li, Yun, Fu, Amy K. Y., Guo, Qihao, Ip, Nancy Y.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 20.02.2018
• Series: Inaugural Article
• Subjects: Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease - genetics; Alzheimer Disease - immunology; Alzheimer Disease - pathology; Alzheimer's disease; Apolipoprotein E; Apolipoproteins E - genetics; Asian People - genetics; Biological Sciences; Biomarkers; Blood; China; Cohort Studies; Female; Gene expression; Gene sequencing; Genetic Predisposition to Disease; Genetics; Genome-Wide Association Study; Genomes; Genotype; Genotypes; Geriatrics; Humans; Immune system; Immune System - immunology; Loci; Male; Middle Aged; Network analysis; Neurodegenerative diseases; Older people; Pathogenesis; Phenotypes; Potassium Channels, Inwardly Rectifying - genetics; Potassium Channels, Inwardly Rectifying - immunology; Risk; Risk analysis; Risk Factors; Transcription; China; GWAS; immune; Alzheimer’s disease; whole-genome sequencing; risk variant

Alzheimer’s disease (AD) is a leading cause of mortality among the elderly. We performed a whole-genome sequencing study of AD in the Chinese population. In addition to the variants identified in or around the APOE locus (sentinel variant rs73052335, P = 1.44 × 10−14), two common variants, GCH1 (rs7...