AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity

► Skeletal muscle AMPK regulated fatty acid metabolism and mitochondrial biogenesis. ► AMPK, exercise, metabolism and implications in obesity. ► AMPK mediated-adaptations to exercise training. ► AMPK as a potential therapeutic target for obesity-induced insulin resistance. Skeletal muscle plays an i...

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Bibliographic Details
Published inMolecular and cellular endocrinology Vol. 366; no. 2; pp. 135 - 151
Main Authors O’Neill, Hayley M., Holloway, Graham P., Steinberg, Gregory R.
Format Journal Article
LanguageEnglish
Published Ireland Elsevier Ireland Ltd 25.02.2013
Subjects
AMP-activated protein kinase
AMP-Activated Protein Kinases - genetics
AMP-Activated Protein Kinases - metabolism
AMPK
biogenesis
Energy Metabolism - physiology
Exercise
Exercise - physiology
Fatty acid
fatty acid metabolism
Fatty Acids - metabolism
Gene Expression Regulation
glucose
Glucose - metabolism
homeostasis
Humans
Insulin - metabolism
Insulin Resistance
Lipid Metabolism - physiology
lipid peroxidation
Mitochondria
Mitochondrial Turnover - physiology
Muscle, Skeletal - metabolism
muscles
noninsulin-dependent diabetes mellitus
Obesity
Obesity - genetics
Obesity - metabolism
Obesity - pathology
Oxidation-Reduction
Signal Transduction
skeletal muscle
MGCAT
ATGL
OXPHOS
LCFA
TZDs
Mitochondria
CREB
Exercise
CPT-I
Fatty acid
HSL
m.CoA
Obesity
PKA
DGAT
PGC-1α
SIRT1
ACC2
MCD
MEF
CaMKII
AMPK
GPA
Insulin resistance
AICAR
ZMP
GPAT
HDAC
Online AccessGet full text
ISSN0303-7207
1872-8057
1872-8057
DOI10.1016/j.mce.2012.06.019

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Abstract ► Skeletal muscle AMPK regulated fatty acid metabolism and mitochondrial biogenesis. ► AMPK, exercise, metabolism and implications in obesity. ► AMPK mediated-adaptations to exercise training. ► AMPK as a potential therapeutic target for obesity-induced insulin resistance. Skeletal muscle plays an important role in regulating whole-body energy expenditure given it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally linked through their association with skeletal muscle insulin resistance, while conversely exercise is known to improve whole body glucose homeostasis simultaneously with muscle insulin sensitivity. Exercise activates skeletal muscle AMP-activated protein kinase (AMPK). AMPK plays a role in regulating exercise capacity, skeletal muscle mitochondrial content and contraction-stimulated glucose uptake. Skeletal muscle AMPK is also thought to be important for regulating fatty acid metabolism; however, direct genetic evidence in this area is currently lacking. This review will discuss the current paradigms regarding the influence of AMPK in regulating skeletal muscle fatty acid metabolism and mitochondrial biogenesis at rest and during exercise, and highlight the potential implications in the development of insulin resistance.
AbstractList Skeletal muscle plays an important role in regulating whole-body energy expenditure given it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally linked through their association with skeletal muscle insulin resistance, while conversely exercise is known to improve whole body glucose homeostasis simultaneously with muscle insulin sensitivity. Exercise activates skeletal muscle AMP-activated protein kinase (AMPK). AMPK plays a role in regulating exercise capacity, skeletal muscle mitochondrial content and contraction-stimulated glucose uptake. Skeletal muscle AMPK is also thought to be important for regulating fatty acid metabolism; however, direct genetic evidence in this area is currently lacking. This review will discuss the current paradigms regarding the influence of AMPK in regulating skeletal muscle fatty acid metabolism and mitochondrial biogenesis at rest and during exercise, and highlight the potential implications in the development of insulin resistance.Skeletal muscle plays an important role in regulating whole-body energy expenditure given it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally linked through their association with skeletal muscle insulin resistance, while conversely exercise is known to improve whole body glucose homeostasis simultaneously with muscle insulin sensitivity. Exercise activates skeletal muscle AMP-activated protein kinase (AMPK). AMPK plays a role in regulating exercise capacity, skeletal muscle mitochondrial content and contraction-stimulated glucose uptake. Skeletal muscle AMPK is also thought to be important for regulating fatty acid metabolism; however, direct genetic evidence in this area is currently lacking. This review will discuss the current paradigms regarding the influence of AMPK in regulating skeletal muscle fatty acid metabolism and mitochondrial biogenesis at rest and during exercise, and highlight the potential implications in the development of insulin resistance.
Skeletal muscle plays an important role in regulating whole-body energy expenditure given it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally linked through their association with skeletal muscle insulin resistance, while conversely exercise is known to improve whole body glucose homeostasis simultaneously with muscle insulin sensitivity. Exercise activates skeletal muscle AMP-activated protein kinase (AMPK). AMPK plays a role in regulating exercise capacity, skeletal muscle mitochondrial content and contraction-stimulated glucose uptake. Skeletal muscle AMPK is also thought to be important for regulating fatty acid metabolism; however, direct genetic evidence in this area is currently lacking. This review will discuss the current paradigms regarding the influence of AMPK in regulating skeletal muscle fatty acid metabolism and mitochondrial biogenesis at rest and during exercise, and highlight the potential implications in the development of insulin resistance.
► Skeletal muscle AMPK regulated fatty acid metabolism and mitochondrial biogenesis. ► AMPK, exercise, metabolism and implications in obesity. ► AMPK mediated-adaptations to exercise training. ► AMPK as a potential therapeutic target for obesity-induced insulin resistance. Skeletal muscle plays an important role in regulating whole-body energy expenditure given it is a major site for glucose and lipid oxidation. Obesity and type 2 diabetes are causally linked through their association with skeletal muscle insulin resistance, while conversely exercise is known to improve whole body glucose homeostasis simultaneously with muscle insulin sensitivity. Exercise activates skeletal muscle AMP-activated protein kinase (AMPK). AMPK plays a role in regulating exercise capacity, skeletal muscle mitochondrial content and contraction-stimulated glucose uptake. Skeletal muscle AMPK is also thought to be important for regulating fatty acid metabolism; however, direct genetic evidence in this area is currently lacking. This review will discuss the current paradigms regarding the influence of AMPK in regulating skeletal muscle fatty acid metabolism and mitochondrial biogenesis at rest and during exercise, and highlight the potential implications in the development of insulin resistance.
Author O’Neill, Hayley M.
Holloway, Graham P.
Steinberg, Gregory R.
Author_xml – sequence: 1
  givenname: Hayley M.
  surname: O’Neill
  fullname: O’Neill, Hayley M.
  email: honeill@mcmaster.ca
  organization: University of Melbourne, Department of Medicine, St. Vincent’s Institute of Medical Research, Melbourne, Victoria 3065, Australia
– sequence: 2
  givenname: Graham P.
  surname: Holloway
  fullname: Holloway, Graham P.
  organization: University of Guelph, Department of Human Health and Nutritional Science, Guelph, Ontario, Canada N1G 2W1
– sequence: 3
  givenname: Gregory R.
  surname: Steinberg
  fullname: Steinberg, Gregory R.
  organization: McMaster University, Department of Medicine, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5
BackLink https://www.ncbi.nlm.nih.gov/pubmed/22750049$$D View this record in MEDLINE/PubMed
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Issue 2
Keywords MGCAT
ATGL
OXPHOS
LCFA
TZDs
Mitochondria
CREB
Exercise
CPT-I
Fatty acid
HSL
m.CoA
Obesity
PKA
DGAT
PGC-1α
SIRT1
ACC2
MCD
MEF
CaMKII
AMPK
GPA
Insulin resistance
AICAR
ZMP
GPAT
HDAC
Language English
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Snippet ► Skeletal muscle AMPK regulated fatty acid metabolism and mitochondrial biogenesis. ► AMPK, exercise, metabolism and implications in obesity. ► AMPK...
Skeletal muscle plays an important role in regulating whole-body energy expenditure given it is a major site for glucose and lipid oxidation. Obesity and type...
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SubjectTerms AMP-activated protein kinase
AMP-Activated Protein Kinases - genetics
AMP-Activated Protein Kinases - metabolism
AMPK
biogenesis
Energy Metabolism - physiology
Exercise
Exercise - physiology
Fatty acid
fatty acid metabolism
Fatty Acids - metabolism
Gene Expression Regulation
glucose
Glucose - metabolism
homeostasis
Humans
Insulin - metabolism
Insulin Resistance
Lipid Metabolism - physiology
lipid peroxidation
Mitochondria
Mitochondrial Turnover - physiology
Muscle, Skeletal - metabolism
muscles
noninsulin-dependent diabetes mellitus
Obesity
Obesity - genetics
Obesity - metabolism
Obesity - pathology
Oxidation-Reduction
Signal Transduction
skeletal muscle
Title AMPK regulation of fatty acid metabolism and mitochondrial biogenesis: Implications for obesity
URI https://dx.doi.org/10.1016/j.mce.2012.06.019
https://www.ncbi.nlm.nih.gov/pubmed/22750049
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https://www.proquest.com/docview/1694485507
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