Kinetics and Persistence of the Cellular and Humoral Immune Responses to BNT162b2 mRNA Vaccine in SARS-CoV-2-Naive and -Experienced Subjects: Impact of Booster Dose and Breakthrough Infections

• Published in: Frontiers in immunology Vol. 13; p. 863554
• Main Authors: Desmecht, Salomé, Tashkeev, Aleksandr, El Moussaoui, Majdouline, Marechal, Nicole, Perée, Hélène, Tokunaga, Yumie, Fombellida-Lopez, Celine, Polese, Barbara, Legrand, Céline, Wéry, Marie, Mni, Myriam, Fouillien, Nicolas, Toussaint, Françoise, Gillet, Laurent, Bureau, Fabrice, Lutteri, Laurence, Hayette, Marie-Pierre, Moutschen, Michel, Meuris, Christelle, Vermeersch, Pieter, Desmecht, Daniel, Rahmouni, Souad, Darcis, Gilles
• Format: Journal Article Web Resource
• Language: English
• Published: Switzerland Frontiers Research Foundation 31.05.2022; Frontiers Media S.A
• Subjects: Antibodies, Viral; BNT162 Vaccine; BNT162b2 mRNA vaccine; COVID-19; COVID-19 - prevention & control; COVID-19 Vaccines; Human health sciences; Humans; IFN-γ; Immunity, Humoral; Immunoglobulin G; Immunologie & maladie infectieuse; Immunology; Immunology & infectious disease; Immunology and Allergy; Kinetics; mRNA Vaccines; neutralizing antibodies; Prospective Studies; SARS- CoV-2; Sciences de la santé humaine; Vaccines, Synthetic; Viral Vaccines; BNT162b2 mRNA vaccine; COVID-19; neutralizing antibodies; IFN-γ; SARS- CoV-2

Understanding and measuring the individual level of immune protection and its persistence at both humoral and cellular levels after SARS-CoV-2 vaccination is mandatory for the management of the vaccination booster campaign. Our prospective study was designed to assess the immunogenicity of the BNT16...