Subretinal Transplant of Human Amniotic Membrane in Advanced Age-Related Macular Degeneration
Macular neovascularization (MNV) and geographic atrophy can complicate age-related macular degeneration (AMD) and lead to severe visual acuity reduction. Despite the medical treatments available, with a defect in the retinal pigmented epithelium (RPE) there is no possibility of restoring acceptable...
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Published in | Life (Basel, Switzerland) Vol. 12; no. 12; p. 1998 |
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30.11.2022
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Abstract | Macular neovascularization (MNV) and geographic atrophy can complicate age-related macular degeneration (AMD) and lead to severe visual acuity reduction. Despite the medical treatments available, with a defect in the retinal pigmented epithelium (RPE) there is no possibility of restoring acceptable visual acuity. We evaluated postoperative outcomes in patients affected by advanced AMD who underwent subretinal implant of the human amniotic membrane (hAM) as a source of pluripotent stem cells. This retrospective, consecutive, non-randomized interventional study included 23 eyes of 21 patients affected by AMD complicated by MNV, and five eyes of five patients affected by geographic atrophy. All eyes underwent a pars plana vitrectomy, neovascular membrane removal for the MNV group, a subretinal implant of hAM, and gas tamponade, and were followed for 12 months. The primary study outcome was visual acuity improvement. Secondary outcomes were postoperative complications, OCT-angiography parameters correlated with best-corrected visual acuity (BCVA) and MNV recurrence. The mean preoperative BCVA was 1.9 logMAR, and the mean final BCVA value was 1.2 logMAR. In the MNV group, the mean BCVA improved from 1.84 logMAR to 1.26 logMAR, and from 1.84 logMAR to 1.32 logMAR in the geographic atrophy group. No MNV recurrence was evident in 12 months of follow-up. An OCT-angiography scan was used to evaluate the retinal vascularization in the treated eye, which showed a high correlation between BCVA and deep vascular density. This study demonstrates the hAM potential and safety in promoting a partial restoration of retinal function together with an increase in visual acuity. |
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AbstractList | Macular neovascularization (MNV) and geographic atrophy can complicate age-related macular degeneration (AMD) and lead to severe visual acuity reduction. Despite the medical treatments available, with a defect in the retinal pigmented epithelium (RPE) there is no possibility of restoring acceptable visual acuity. We evaluated postoperative outcomes in patients affected by advanced AMD who underwent subretinal implant of the human amniotic membrane (hAM) as a source of pluripotent stem cells. This retrospective, consecutive, non-randomized interventional study included 23 eyes of 21 patients affected by AMD complicated by MNV, and five eyes of five patients affected by geographic atrophy. All eyes underwent a pars plana vitrectomy, neovascular membrane removal for the MNV group, a subretinal implant of hAM, and gas tamponade, and were followed for 12 months. The primary study outcome was visual acuity improvement. Secondary outcomes were postoperative complications, OCT-angiography parameters correlated with best-corrected visual acuity (BCVA) and MNV recurrence. The mean preoperative BCVA was 1.9 logMAR, and the mean final BCVA value was 1.2 logMAR. In the MNV group, the mean BCVA improved from 1.84 logMAR to 1.26 logMAR, and from 1.84 logMAR to 1.32 logMAR in the geographic atrophy group. No MNV recurrence was evident in 12 months of follow-up. An OCT-angiography scan was used to evaluate the retinal vascularization in the treated eye, which showed a high correlation between BCVA and deep vascular density. This study demonstrates the hAM potential and safety in promoting a partial restoration of retinal function together with an increase in visual acuity. |
Audience | Academic |
Author | Caporossi, Tomaso Baldascino, Antonio Governatori, Lorenzo Rizzo, Stanislao Carlà, Matteo Mario Kilian, Raphael Rizzo, Clara Gambini, Gloria Crincoli, Emanuele Pacini, Bianca Bacherini, Daniela Scampoli, Alessandra |
AuthorAffiliation | 6 Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, 56124 Pisa, Italy 3 Department of NEUROFARBA, Ophthalmology, University of Florence, Careggi, 50139 Florence, Italy 5 Ophthalmology Unit, University of Verona, 37129 Verona, Italy 2 Ophthalmology Unit, Catholic University “Sacro Cuore”, 00168 Rome, Italy 1 Ophthalmology Unit, “Fondazione Policlinico Universitario A. Gemelli IRCCS”, 00168 Rome, Italy 4 Ophthalmology Unit, Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, 56122 Pisa, Italy |
AuthorAffiliation_xml | – name: 6 Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, 56124 Pisa, Italy – name: 5 Ophthalmology Unit, University of Verona, 37129 Verona, Italy – name: 2 Ophthalmology Unit, Catholic University “Sacro Cuore”, 00168 Rome, Italy – name: 3 Department of NEUROFARBA, Ophthalmology, University of Florence, Careggi, 50139 Florence, Italy – name: 4 Ophthalmology Unit, Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, 56122 Pisa, Italy – name: 1 Ophthalmology Unit, “Fondazione Policlinico Universitario A. Gemelli IRCCS”, 00168 Rome, Italy |
Author_xml | – sequence: 1 givenname: Tomaso orcidid: 0000-0002-6902-2983 surname: Caporossi fullname: Caporossi, Tomaso organization: Ophthalmology Unit, Catholic University "Sacro Cuore", 00168 Rome, Italy – sequence: 2 givenname: Alessandra surname: Scampoli fullname: Scampoli, Alessandra organization: Ophthalmology Unit, Catholic University "Sacro Cuore", 00168 Rome, Italy – sequence: 3 givenname: Antonio orcidid: 0000-0002-8934-8665 surname: Baldascino fullname: Baldascino, Antonio organization: Ophthalmology Unit, Catholic University "Sacro Cuore", 00168 Rome, Italy – sequence: 4 givenname: Gloria surname: Gambini fullname: Gambini, Gloria organization: Ophthalmology Unit, Catholic University "Sacro Cuore", 00168 Rome, Italy – sequence: 5 givenname: Bianca surname: Pacini fullname: Pacini, Bianca organization: Department of NEUROFARBA, Ophthalmology, University of Florence, Careggi, 50139 Florence, Italy – sequence: 6 givenname: Lorenzo surname: Governatori fullname: Governatori, Lorenzo organization: Department of NEUROFARBA, Ophthalmology, University of Florence, Careggi, 50139 Florence, Italy – sequence: 7 givenname: Daniela orcidid: 0000-0001-7578-7563 surname: Bacherini fullname: Bacherini, Daniela organization: Department of NEUROFARBA, Ophthalmology, University of Florence, Careggi, 50139 Florence, Italy – sequence: 8 givenname: Matteo Mario orcidid: 0000-0003-2979-1638 surname: Carlà fullname: Carlà, Matteo Mario organization: Ophthalmology Unit, Catholic University "Sacro Cuore", 00168 Rome, Italy – sequence: 9 givenname: Emanuele orcidid: 0000-0001-9996-9871 surname: Crincoli fullname: Crincoli, Emanuele organization: Ophthalmology Unit, Catholic University "Sacro Cuore", 00168 Rome, Italy – sequence: 10 givenname: Clara surname: Rizzo fullname: Rizzo, Clara organization: Ophthalmology Unit, Department of Surgical, Medical, Molecular and Critical Area Pathology, University of Pisa, 56122 Pisa, Italy – sequence: 11 givenname: Raphael surname: Kilian fullname: Kilian, Raphael organization: Ophthalmology Unit, University of Verona, 37129 Verona, Italy – sequence: 12 givenname: Stanislao surname: Rizzo fullname: Rizzo, Stanislao organization: Consiglio Nazionale delle Ricerche, Istituto di Neuroscienze, 56124 Pisa, Italy |
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Keywords | OCT-angiography stem cells regenerative ophthalmology macular neovascularization human amniotic membrane vitrectomy age-related macular degeneration |
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Snippet | Macular neovascularization (MNV) and geographic atrophy can complicate age-related macular degeneration (AMD) and lead to severe visual acuity reduction.... |
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StartPage | 1998 |
SubjectTerms | Acuity Age Age related diseases age-related macular degeneration Amnion Amniotic membrane Amniotic sac Angiography Atrophy Care and treatment Complications Epithelium Extracellular matrix Eye Eye diseases Growth factors Health aspects Homeopathy human amniotic membrane Immunology Laboratories Macular degeneration macular neovascularization Materia medica and therapeutics Medical imaging Medical research Medical treatment Medicine, Experimental Membranes Methods OCT-angiography Photoreceptors Physiological aspects Pluripotency Postoperative regenerative ophthalmology Retina Retinal detachment Retinal pigment epithelium Statistical analysis Stem cells Surgery Tamponade Therapeutics Transplantation of organs, tissues, etc Variance analysis Vascularization Visual acuity |
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Title | Subretinal Transplant of Human Amniotic Membrane in Advanced Age-Related Macular Degeneration |
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