Bile Acid Receptor Activation Modulates Hepatic Monocyte Activity and Improves Nonalcoholic Fatty Liver Disease

• Published in: The Journal of biological chemistry Vol. 288; no. 17; pp. 11761 - 11770
• Main Authors: McMahan, Rachel H., Wang, Xiaoxin X., Cheng, Lin Ling, Krisko, Tibor, Smith, Maxwell, El Kasmi, Karim, Pruzanski, Mark, Adorini, Luciano, Golden-Mason, Lucy, Levi, Moshe, Rosen, Hugo R.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 26.04.2013; American Society for Biochemistry and Molecular Biology
• Subjects: Animals; Cyclic AMP - immunology; Cyclic AMP - metabolism; Fatty Liver - immunology; Fatty Liver - metabolism; Fatty Liver - pathology; FXR; Gene Expression Regulation - immunology; Humans; IL-10; Immunology; Intercellular Signaling Peptides and Proteins - biosynthesis; Intercellular Signaling Peptides and Proteins - immunology; Interleukin-10 - biosynthesis; Interleukin-10 - immunology; Lectins, C-Type - biosynthesis; Lectins, C-Type - immunology; Liver; Liver - immunology; Liver - metabolism; Liver - pathology; Macrophage Activation - immunology; Macrophages; Macrophages - immunology; Macrophages - metabolism; Male; Mannose-Binding Lectins - biosynthesis; Mannose-Binding Lectins - immunology; Mice; Mice, Obese; Monocytes; Monocytes - immunology; Monocytes - metabolism; Monocytes - pathology; Mouse; Non-alcoholic Fatty Liver Disease; Receptors, Cell Surface - biosynthesis; Receptors, Cell Surface - immunology; Receptors, Cytoplasmic and Nuclear - immunology; Receptors, Cytoplasmic and Nuclear - metabolism; Receptors, G-Protein-Coupled - immunology; Receptors, G-Protein-Coupled - metabolism; Steatosis; TGR5; FXR; TGR5; Monocytes; Immunology; Mouse; Liver; Macrophages; IL-10; Steatosis

Nonalcoholic fatty liver disease (NAFLD) affects a large proportion of the American population. The spectrum of disease ranges from bland steatosis without inflammation to nonalcoholic steatohepatitis and cirrhosis. Bile acids are critical regulators of hepatic lipid and glucose metabolism and signa...