Combined visual and quantitative assessment of somatostatin receptor scintigraphy for staging and restaging of neuroendocrine tumors

• Published in: Japanese journal of radiology Vol. 42; no. 5; pp. 519 - 535
• Main Authors: Ueki, Yuya, Otsuka, Hideki, Otani, Tamaki, Kasai, Ryosuke, Otomi, Yoichi, Ikemitsu, Daiki, Azane, Shota, Kunikane, Yamato, Bando, Takanori, Matsuda, Noritake, Okada, Yasuyuki, Takayama, Tetsuji, Harada, Masafumi
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.05.2024; Springer Nature B.V
• Subjects: Adult; Aged; Aged, 80 and over; Computed tomography; Female; Humans; Imaging; Kidneys; Lesions; Liver; Male; Medical imaging; Medicine; Medicine & Public Health; Metastases; Middle Aged; Neoplasm Staging; Neuroendocrine tumors; Neuroendocrine Tumors - diagnostic imaging; Neuroendocrine Tumors - pathology; Nuclear Medicine; Octreotide; Original Article; Photon emission; Physiology; Quantitative analysis; Radiology; Radiopharmaceuticals; Radiotherapy; Receptors; Receptors, Somatostatin - metabolism; Retrospective Studies; Scintigraphy; Single photon emission computed tomography; Somatostatin; Somatostatin - analogs & derivatives; Spleen; Tomography, Emission-Computed, Single-Photon - methods; Tumor markers; Tumors; Standardized uptake value (SUV); Becquerel calibration factor (BCF); Somatostatin receptor (SSTR); In-pentetreotide; Neuroendocrine tumors (NETs); Somatostatin receptor scintigraphy (SRS); 111In-pentetreotide
• ISSN: 1867-1071; 1867-108X; 1867-108X
• DOI: 10.1007/s11604-024-01529-z

Purpose Somatostatin receptor scintigraphy (SRS) using 111 In-DTPA-DPhe 1 -octreotide (pentetreotide) has become an integral part of neuroendocrine neoplasm management. The lack of precise quantification is a disadvantage of SRS. This study aimed to adapt the standardized uptake value (SUV) to SRS, establish the SUV range for physiological uptake in the liver, kidney, and spleen, and elucidate the utility of combined visual and quantitative SRS assessment for staging and restaging of neuroendocrine tumors (NETs). Materials and methods This study included 21 patients with NETs who underwent 111 In-pentetreotide SRS. The SUV of physiological and pathological uptake was calculated using bone single-photon emission computed tomography (SPECT) quantitative analysis software (GI-BONE). For visual analysis, the primary and metastatic lesions were scored visually on planar and SPECT images using a five-point scale. We assessed the relationships between the SUVs of the liver, kidney, and spleen in the dual phase, and among quantitative indices, visual score, and pathological lesions classification. Results Sixty-three NEN lesions were evaluated. The mean ± standard deviation maximum SUVs (SUVmax) were liver: 4 h, 2.6 ± 1.0; 24 h, 2.2 ± 1.0; kidney: 4 h, 8.9 ± 1.8; 24 h, 7.0 ± 2.0; and spleen; 4 h, 11.3 ± 4.5; 24 h, 11.5 ± 7.6. Higher SUVmax was significantly associated with higher visual scores on dual-phase SPECT (4 h, p  < 0.001; 24 h, p  < 0.001) (4 h: scores 3 and 4, p  < 0.05; scores 3 and 5: p  < 0.01; scores 4 and 5: p  < 0.01; 24 h: scores 3 and 4, p  = 0.0748; scores 3 and 5: p  < 0.01; scores 4 and 5: p  < 0.01). Conclusion We adapted the SUV to SRS and established the range of SUV for physiological uptake in the liver, kidney, and spleen. Combined visual and quantitative assessment is useful for imaging individual lesions in greater detail, and may serve as a new tumor marker of SRS for staging and restaging of NETs.