Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 114; no. 37; pp. E7697 - E7706
• Main Authors: Satoh, Kiyotoshi, Yachida, Shinichi, Sugimoto, Masahiro, Oshima, Minoru, Nakagawa, Toshitaka, Akamoto, Shintaro, Tabata, Sho, Saitoh, Kaori, Kato, Keiko, Sato, Saya, Igarashi, Kaori, Aizawa, Yumi, Kajino-Sakamoto, Rie, Kojima, Yasushi, Fujishita, Teruaki, Enomoto, Ayame, Hirayama, Akiyoshi, Ishikawa, Takamasa, Taketo, Makoto Mark, Kushida, Yoshio, Haba, Reiji, Okano, Keiichi, Tomita, Masaru, Suzuki, Yasuyuki, Fukuda, Shinji, Aoki, Masahiro, Soga, Tomoyoshi
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 12.09.2017
• Series: PNAS Plus
• Subjects: Aberration; Adenoma; Biological Sciences; Cancer; Cancer therapies; Carcinogenesis; Carcinogens; Colorectal cancer; Colorectal carcinoma; Deoxyribonucleic acid; DNA; DNA methylation; Evolution; Gene expression; Genes; Macromolecules; Metabolism; Mitochondria; Mutation; Myc protein; PNAS Plus; Studies; Tumors; metabolism; colorectal cancer; omics; metabolomics; MYC

Cancer cells alter their metabolism for the production of precursors of macromolecules. However, the control mechanisms underlying this reprogramming are poorly understood. Here we show that metabolic reprogramming of colorectal cancer is caused chiefly by aberrant MYC expression. Multiomics-based a...