Limitations in transplantation of astroglia-biomatrix bridges to stimulate corticospinal axon regrowth across large spinal lesion gaps

• Published in: Neuroscience letters Vol. 400; no. 3; pp. 208 - 212
• Main Authors: Deumens, Ronald, Koopmans, Guido C., Honig, Wiel M.M., Maquet, Véronique, Jérôme, Robert, Steinbusch, Harry W.M., Joosten, Elbert A.J.
• Format: Journal Article Web Resource
• Language: English
• Published: Shannon Elsevier Ireland Ltd 12.06.2006; Elsevier
• Subjects: Alignment; Animals; Astrocytes - transplantation; Axons - pathology; Biocompatible Materials - chemistry; Biological and medical sciences; biomaterial; Biomimetic Materials - chemistry; Chemistry; Chimie; Corticospinal; Development. Senescence. Regeneration. Transplantation; Engineering, computing & technology; Extracellular Matrix - chemistry; Fundamental and applied biological sciences. Psychology; Ingénierie, informatique & technologie; Locomotion; Male; Materials science & engineering; Nerve Regeneration - physiology; Physical, chemical, mathematical & earth Sciences; Physique, chimie, mathématiques & sciences de la terre; Polyesters - chemistry; Polylactides; Pyramidal Tracts - growth & development; Pyramidal Tracts - injuries; Rat; Rats; Rats, Inbred Lew; scaffold; Science des matériaux & ingénierie; Spinal Cord Injuries - diagnosis; Spinal Cord Injuries - physiopathology; Spinal Cord Injuries - surgery; Spinal cord injury; Thoracic Vertebrae - injuries; Tissue Engineering - methods; Treatment Outcome; Vertebrates: nervous system and sense organs; Locomotion; Alignment; Polylactides; Rat; Spinal cord injury; Corticospinal; Spinal cord; Rodentia; Central nervous system; Axon; Corticospinal bundle; Transplantation; Vertebrata; Mammalia; Pyramidal motor pathway; Animal; Lesion; Motricity

Regrowth of injured axons across rather small spinal cord lesion gaps and subsequent functional recovery has been obtained after many interventions. Long-distance regeneration of injured axons across clinically relevant large spinal lesion gaps is relatively unexplored. Here, we aimed at stimulating...