The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults
δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear mechanisms. Elevated plasma apoB-lipoproteins (measu...
Saved in:
| Published in | The Journal of nutrition Vol. 149; no. 1; pp. 57 - 67 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
01.01.2019
Oxford University Press American Institute of Nutrition |
| Subjects | |
| Online Access | Get full text |
| ISSN | 0022-3166 1541-6100 1541-6100 |
| DOI | 10.1093/jn/nxy238 |
Cover
Loading…
| Abstract | δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear mechanisms. Elevated plasma apoB-lipoproteins (measured as plasma apoB), which can be reduced by n–3 PUFA intake, promote T2D risk factors.
The aim of this study was to test the hypothesis that the association of D5D and D6D activities with T2D risk factors is dependent on plasma apoB.
This is a pooled analysis of 2 populations recruited for 2 different metabolic studies. It is a post hoc analysis of baseline data of these subjects [n = 98; 60% women (postmenopausal); mean ± SD body mass index (in kg/m2): 32.8 ± 4.7; mean ± SD age: 57.6 ± 6.3 y]. Glucose-induced insulin secretion (GIIS) and insulin sensitivity (IS) were measured using Botnia clamps. Plasma clearance of a high-fat meal (600 kcal/m2, 66% fat) and white adipose tissue (WAT) function (storage of 3H-triolein-labeled substrate) were assessed in a subpopulation (n = 47). Desaturase activities were estimated from plasma phospholipid fatty acids. Associations were examined using Pearson and partial correlations.
While both desaturase activities were positively associated with percentage of eicosapentaenoic acid, only D5D was negatively associated with plasma apoB (r = −0.30, P = 0.003). Association of D5D activity with second-phase GIIS (r = −0.23, P = 0.029), IS (r = 0.33, P = 0.015, in women) and 6-h area-under-the-curve (AUC6h) of plasma chylomicrons (apoB48, r = −0.47, P = 0.020, in women) was independent of age and adiposity, but was eliminated after adjustment for plasma apoB. D6D activity was associated in the opposite direction with GIIS (r = 0.24, P = 0.049), IS (r = −0.36, P = 0.004) and AUC6h chylomicrons (r = 0.52, P = 0.004), independent of plasma apoB. Both desaturases were associated with plasma interleukin-1-receptor antagonist (D5D: r = −0.45, P < 0.001 in women; D6D: r = −0.33, P = 0.007) and WAT function (trend for D5D: r = 0.30, P = 0.05; D6D: r = 0.39, P = 0.027) independent of any adjustment.
Association of D5D activity with IS, lower GIIS, and plasma chylomicron clearance is dependent on plasma apoB in overweight and obese adults. |
|---|---|
| AbstractList | δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear mechanisms. Elevated plasma apoB-lipoproteins (measured as plasma apoB), which can be reduced by n–3 PUFA intake, promote T2D risk factors. The aim of this study was to test the hypothesis that the association of D5D and D6D activities with T2D risk factors is dependent on plasma apoB. This is a pooled analysis of 2 populations recruited for 2 different metabolic studies. It is a post hoc analysis of baseline data of these subjects [n = 98; 60% women (postmenopausal); mean ± SD body mass index (in kg/m²): 32.8 ± 4.7; mean ± SD age: 57.6 ± 6.3 y]. Glucose-induced insulin secretion (GIIS) and insulin sensitivity (IS) were measured using Botnia clamps. Plasma clearance of a high-fat meal (600 kcal/m², 66% fat) and white adipose tissue (WAT) function (storage of ³H-triolein-labeled substrate) were assessed in a subpopulation (n = 47). Desaturase activities were estimated from plasma phospholipid fatty acids. Associations were examined using Pearson and partial correlations. While both desaturase activities were positively associated with percentage of eicosapentaenoic acid, only D5D was negatively associated with plasma apoB (r = −0.30, P = 0.003). Association of D5D activity with second-phase GIIS (r = −0.23, P = 0.029), IS (r = 0.33, P = 0.015, in women) and 6-h area-under-the-curve (AUC₆ₕ) of plasma chylomicrons (apoB48, r = −0.47, P = 0.020, in women) was independent of age and adiposity, but was eliminated after adjustment for plasma apoB. D6D activity was associated in the opposite direction with GIIS (r = 0.24, P = 0.049), IS (r = −0.36, P = 0.004) and AUC₆ₕ chylomicrons (r = 0.52, P = 0.004), independent of plasma apoB. Both desaturases were associated with plasma interleukin-1-receptor antagonist (D5D: r = −0.45, P < 0.001 in women; D6D: r = −0.33, P = 0.007) and WAT function (trend for D5D: r = 0.30, P = 0.05; D6D: r = 0.39, P = 0.027) independent of any adjustment. Association of D5D activity with IS, lower GIIS, and plasma chylomicron clearance is dependent on plasma apoB in overweight and obese adults. ABSTRACT Background δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear mechanisms. Elevated plasma apoB-lipoproteins (measured as plasma apoB), which can be reduced by n–3 PUFA intake, promote T2D risk factors. Objective The aim of this study was to test the hypothesis that the association of D5D and D6D activities with T2D risk factors is dependent on plasma apoB. Methods This is a pooled analysis of 2 populations recruited for 2 different metabolic studies. It is a post hoc analysis of baseline data of these subjects [n = 98; 60% women (postmenopausal); mean ± SD body mass index (in kg/m2): 32.8 ± 4.7; mean ± SD age: 57.6 ± 6.3 y]. Glucose-induced insulin secretion (GIIS) and insulin sensitivity (IS) were measured using Botnia clamps. Plasma clearance of a high-fat meal (600 kcal/m2, 66% fat) and white adipose tissue (WAT) function (storage of 3H-triolein-labeled substrate) were assessed in a subpopulation (n = 47). Desaturase activities were estimated from plasma phospholipid fatty acids. Associations were examined using Pearson and partial correlations. Results While both desaturase activities were positively associated with percentage of eicosapentaenoic acid, only D5D was negatively associated with plasma apoB (r = −0.30, P = 0.003). Association of D5D activity with second-phase GIIS (r = −0.23, P = 0.029), IS (r = 0.33, P = 0.015, in women) and 6-h area-under-the-curve (AUC6h) of plasma chylomicrons (apoB48, r = −0.47, P = 0.020, in women) was independent of age and adiposity, but was eliminated after adjustment for plasma apoB. D6D activity was associated in the opposite direction with GIIS (r = 0.24, P = 0.049), IS (r = −0.36, P = 0.004) and AUC6h chylomicrons (r = 0.52, P = 0.004), independent of plasma apoB. Both desaturases were associated with plasma interleukin-1-receptor antagonist (D5D: r = −0.45, P < 0.001 in women; D6D: r = −0.33, P = 0.007) and WAT function (trend for D5D: r = 0.30, P = 0.05; D6D: r = 0.39, P = 0.027) independent of any adjustment. Conclusions Association of D5D activity with IS, lower GIIS, and plasma chylomicron clearance is dependent on plasma apoB in overweight and obese adults. δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n-3 (ω-3) and n-6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear mechanisms. Elevated plasma apoB-lipoproteins (measured as plasma apoB), which can be reduced by n-3 PUFA intake, promote T2D risk factors.Backgroundδ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n-3 (ω-3) and n-6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear mechanisms. Elevated plasma apoB-lipoproteins (measured as plasma apoB), which can be reduced by n-3 PUFA intake, promote T2D risk factors.The aim of this study was to test the hypothesis that the association of D5D and D6D activities with T2D risk factors is dependent on plasma apoB.ObjectiveThe aim of this study was to test the hypothesis that the association of D5D and D6D activities with T2D risk factors is dependent on plasma apoB.This is a pooled analysis of 2 populations recruited for 2 different metabolic studies. It is a post hoc analysis of baseline data of these subjects [n = 98; 60% women (postmenopausal); mean ± SD body mass index (in kg/m2): 32.8 ± 4.7; mean ± SD age: 57.6 ± 6.3 y]. Glucose-induced insulin secretion (GIIS) and insulin sensitivity (IS) were measured using Botnia clamps. Plasma clearance of a high-fat meal (600 kcal/m2, 66% fat) and white adipose tissue (WAT) function (storage of 3H-triolein-labeled substrate) were assessed in a subpopulation (n = 47). Desaturase activities were estimated from plasma phospholipid fatty acids. Associations were examined using Pearson and partial correlations.MethodsThis is a pooled analysis of 2 populations recruited for 2 different metabolic studies. It is a post hoc analysis of baseline data of these subjects [n = 98; 60% women (postmenopausal); mean ± SD body mass index (in kg/m2): 32.8 ± 4.7; mean ± SD age: 57.6 ± 6.3 y]. Glucose-induced insulin secretion (GIIS) and insulin sensitivity (IS) were measured using Botnia clamps. Plasma clearance of a high-fat meal (600 kcal/m2, 66% fat) and white adipose tissue (WAT) function (storage of 3H-triolein-labeled substrate) were assessed in a subpopulation (n = 47). Desaturase activities were estimated from plasma phospholipid fatty acids. Associations were examined using Pearson and partial correlations.While both desaturase activities were positively associated with percentage of eicosapentaenoic acid, only D5D was negatively associated with plasma apoB (r = -0.30, P = 0.003). Association of D5D activity with second-phase GIIS (r = -0.23, P = 0.029), IS (r = 0.33, P = 0.015, in women) and 6-h area-under-the-curve (AUC6h) of plasma chylomicrons (apoB48, r = -0.47, P = 0.020, in women) was independent of age and adiposity, but was eliminated after adjustment for plasma apoB. D6D activity was associated in the opposite direction with GIIS (r = 0.24, P = 0.049), IS (r = -0.36, P = 0.004) and AUC6h chylomicrons (r = 0.52, P = 0.004), independent of plasma apoB. Both desaturases were associated with plasma interleukin-1-receptor antagonist (D5D: r = -0.45, P < 0.001 in women; D6D: r = -0.33, P = 0.007) and WAT function (trend for D5D: r = 0.30, P = 0.05; D6D: r = 0.39, P = 0.027) independent of any adjustment.ResultsWhile both desaturase activities were positively associated with percentage of eicosapentaenoic acid, only D5D was negatively associated with plasma apoB (r = -0.30, P = 0.003). Association of D5D activity with second-phase GIIS (r = -0.23, P = 0.029), IS (r = 0.33, P = 0.015, in women) and 6-h area-under-the-curve (AUC6h) of plasma chylomicrons (apoB48, r = -0.47, P = 0.020, in women) was independent of age and adiposity, but was eliminated after adjustment for plasma apoB. D6D activity was associated in the opposite direction with GIIS (r = 0.24, P = 0.049), IS (r = -0.36, P = 0.004) and AUC6h chylomicrons (r = 0.52, P = 0.004), independent of plasma apoB. Both desaturases were associated with plasma interleukin-1-receptor antagonist (D5D: r = -0.45, P < 0.001 in women; D6D: r = -0.33, P = 0.007) and WAT function (trend for D5D: r = 0.30, P = 0.05; D6D: r = 0.39, P = 0.027) independent of any adjustment.Association of D5D activity with IS, lower GIIS, and plasma chylomicron clearance is dependent on plasma apoB in overweight and obese adults.ConclusionsAssociation of D5D activity with IS, lower GIIS, and plasma chylomicron clearance is dependent on plasma apoB in overweight and obese adults. δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear mechanisms. Elevated plasma apoB-lipoproteins (measured as plasma apoB), which can be reduced by n–3 PUFA intake, promote T2D risk factors. The aim of this study was to test the hypothesis that the association of D5D and D6D activities with T2D risk factors is dependent on plasma apoB. This is a pooled analysis of 2 populations recruited for 2 different metabolic studies. It is a post hoc analysis of baseline data of these subjects [n = 98; 60% women (postmenopausal); mean ± SD body mass index (in kg/m2): 32.8 ± 4.7; mean ± SD age: 57.6 ± 6.3 y]. Glucose-induced insulin secretion (GIIS) and insulin sensitivity (IS) were measured using Botnia clamps. Plasma clearance of a high-fat meal (600 kcal/m2, 66% fat) and white adipose tissue (WAT) function (storage of 3H-triolein-labeled substrate) were assessed in a subpopulation (n = 47). Desaturase activities were estimated from plasma phospholipid fatty acids. Associations were examined using Pearson and partial correlations. While both desaturase activities were positively associated with percentage of eicosapentaenoic acid, only D5D was negatively associated with plasma apoB (r = −0.30, P = 0.003). Association of D5D activity with second-phase GIIS (r = −0.23, P = 0.029), IS (r = 0.33, P = 0.015, in women) and 6-h area-under-the-curve (AUC6h) of plasma chylomicrons (apoB48, r = −0.47, P = 0.020, in women) was independent of age and adiposity, but was eliminated after adjustment for plasma apoB. D6D activity was associated in the opposite direction with GIIS (r = 0.24, P = 0.049), IS (r = −0.36, P = 0.004) and AUC6h chylomicrons (r = 0.52, P = 0.004), independent of plasma apoB. Both desaturases were associated with plasma interleukin-1-receptor antagonist (D5D: r = −0.45, P < 0.001 in women; D6D: r = −0.33, P = 0.007) and WAT function (trend for D5D: r = 0.30, P = 0.05; D6D: r = 0.39, P = 0.027) independent of any adjustment. Association of D5D activity with IS, lower GIIS, and plasma chylomicron clearance is dependent on plasma apoB in overweight and obese adults. δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n-3 (ω-3) and n-6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear mechanisms. Elevated plasma apoB-lipoproteins (measured as plasma apoB), which can be reduced by n-3 PUFA intake, promote T2D risk factors. The aim of this study was to test the hypothesis that the association of D5D and D6D activities with T2D risk factors is dependent on plasma apoB. This is a pooled analysis of 2 populations recruited for 2 different metabolic studies. It is a post hoc analysis of baseline data of these subjects [n = 98; 60% women (postmenopausal); mean ± SD body mass index (in kg/m2): 32.8 ± 4.7; mean ± SD age: 57.6 ± 6.3 y]. Glucose-induced insulin secretion (GIIS) and insulin sensitivity (IS) were measured using Botnia clamps. Plasma clearance of a high-fat meal (600 kcal/m2, 66% fat) and white adipose tissue (WAT) function (storage of 3H-triolein-labeled substrate) were assessed in a subpopulation (n = 47). Desaturase activities were estimated from plasma phospholipid fatty acids. Associations were examined using Pearson and partial correlations. While both desaturase activities were positively associated with percentage of eicosapentaenoic acid, only D5D was negatively associated with plasma apoB (r = -0.30, P = 0.003). Association of D5D activity with second-phase GIIS (r = -0.23, P = 0.029), IS (r = 0.33, P = 0.015, in women) and 6-h area-under-the-curve (AUC6h) of plasma chylomicrons (apoB48, r = -0.47, P = 0.020, in women) was independent of age and adiposity, but was eliminated after adjustment for plasma apoB. D6D activity was associated in the opposite direction with GIIS (r = 0.24, P = 0.049), IS (r = -0.36, P = 0.004) and AUC6h chylomicrons (r = 0.52, P = 0.004), independent of plasma apoB. Both desaturases were associated with plasma interleukin-1-receptor antagonist (D5D: r = -0.45, P < 0.001 in women; D6D: r = -0.33, P = 0.007) and WAT function (trend for D5D: r = 0.30, P = 0.05; D6D: r = 0.39, P = 0.027) independent of any adjustment. Association of D5D activity with IS, lower GIIS, and plasma chylomicron clearance is dependent on plasma apoB in overweight and obese adults. Background δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are negatively and positively associated with type 2 diabetes (T2D), respectively, by unclear mechanisms. Elevated plasma apoB-lipoproteins (measured as plasma apoB), which can be reduced by n–3 PUFA intake, promote T2D risk factors. Objective The aim of this study was to test the hypothesis that the association of D5D and D6D activities with T2D risk factors is dependent on plasma apoB. Methods This is a pooled analysis of 2 populations recruited for 2 different metabolic studies. It is a post hoc analysis of baseline data of these subjects [n = 98; 60% women (postmenopausal); mean ± SD body mass index (in kg/m2): 32.8 ± 4.7; mean ± SD age: 57.6 ± 6.3 y]. Glucose-induced insulin secretion (GIIS) and insulin sensitivity (IS) were measured using Botnia clamps. Plasma clearance of a high-fat meal (600 kcal/m2, 66% fat) and white adipose tissue (WAT) function (storage of 3H-triolein-labeled substrate) were assessed in a subpopulation (n = 47). Desaturase activities were estimated from plasma phospholipid fatty acids. Associations were examined using Pearson and partial correlations. Results While both desaturase activities were positively associated with percentage of eicosapentaenoic acid, only D5D was negatively associated with plasma apoB (r = −0.30, P = 0.003). Association of D5D activity with second-phase GIIS (r = −0.23, P = 0.029), IS (r = 0.33, P = 0.015, in women) and 6-h area-under-the-curve (AUC6h) of plasma chylomicrons (apoB48, r = −0.47, P = 0.020, in women) was independent of age and adiposity, but was eliminated after adjustment for plasma apoB. D6D activity was associated in the opposite direction with GIIS (r = 0.24, P = 0.049), IS (r = −0.36, P = 0.004) and AUC6h chylomicrons (r = 0.52, P = 0.004), independent of plasma apoB. Both desaturases were associated with plasma interleukin-1-receptor antagonist (D5D: r = −0.45, P < 0.001 in women; D6D: r = −0.33, P = 0.007) and WAT function (trend for D5D: r = 0.30, P = 0.05; D6D: r = 0.39, P = 0.027) independent of any adjustment. Conclusions Association of D5D activity with IS, lower GIIS, and plasma chylomicron clearance is dependent on plasma apoB in overweight and obese adults. |
| Author | Lamantia, Valérie Rosiers, Christine Des Faraj, May Provost, Viviane Devaux, Marie Daneault, Caroline Bissonnette, Simon Cyr, Yannick |
| AuthorAffiliation | 1 Faculty of Medicine, Université de Montréal, Montréal, Québec 2 Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec 3 Institut de Cardiologie de Montréal (ICM), Montréal, Québec 4 Montreal Diabetes Research Center (MDRC), Montréal, Québec |
| AuthorAffiliation_xml | – name: 3 Institut de Cardiologie de Montréal (ICM), Montréal, Québec – name: 4 Montreal Diabetes Research Center (MDRC), Montréal, Québec – name: 2 Institut de Recherches Cliniques de Montréal (IRCM), Montréal, Québec – name: 1 Faculty of Medicine, Université de Montréal, Montréal, Québec |
| Author_xml | – sequence: 1 givenname: Valérie orcidid: 0000-0002-4643-6462 surname: Lamantia fullname: Lamantia, Valérie organization: Faculty of Medicine, Université de Montréal, Montréal, Québec – sequence: 2 givenname: Simon surname: Bissonnette fullname: Bissonnette, Simon organization: Faculty of Medicine, Université de Montréal, Montréal, Québec – sequence: 3 givenname: Viviane surname: Provost fullname: Provost, Viviane organization: Faculty of Medicine, Université de Montréal, Montréal, Québec – sequence: 4 givenname: Marie surname: Devaux fullname: Devaux, Marie organization: Faculty of Medicine, Université de Montréal, Montréal, Québec – sequence: 5 givenname: Yannick surname: Cyr fullname: Cyr, Yannick organization: Faculty of Medicine, Université de Montréal, Montréal, Québec – sequence: 6 givenname: Caroline surname: Daneault fullname: Daneault, Caroline organization: Institut de Cardiologie de Montréal (ICM), Montréal, Québec – sequence: 7 givenname: Christine Des surname: Rosiers fullname: Rosiers, Christine Des organization: Faculty of Medicine, Université de Montréal, Montréal, Québec – sequence: 8 givenname: May surname: Faraj fullname: Faraj, May email: may.faraj@umontreal.ca organization: Faculty of Medicine, Université de Montréal, Montréal, Québec |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30535058$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFksFuEzEQhleoiKaFAy-ALMEBDkvs9dqbXJBCQ6FSpFQod8trzzYOG3tre1PyXn0OngmHLRVUFZx8-L__nxnPnGRH1lnIspcEvyd4SscbO7bf9wWdPMlGhJUk5wTjo2yEcVHklHB-nJ2EsMEYk3I6eZYdU8wow2wyym5Xa0CzEJwyMhpnkWvQpWv3vQ0y9l5G0OhcxrhHM2U0-nGbs3wOgxaSU0WzM0m9MXGNvprwLdEqOh9Q4zxa7TtABZobWUOEgC4CmkMHVoONKBW7bGXYSjTr3Md8YTrXeRfB2ICMRcsd-BswV-uIpNVoWcOhnu7bGJ5nTxvZBnhx955mq_NPq7Mv-WL5-eJstsgVw9OY1xOFG12yWmmsKqIqRShXktOGalkpPZUNrhpOZEnKA6trhmtJMaesVJrR0-zDENv19Ra0Sk172YrOm630e-GkEX8r1qzFlduJFEAInaSAt3cB3l33EKLYmqCgbaUF1wdRUFaUhOOS_R8ljBFeVpwn9PUDdON6b9NHJKriBeMlrhL16s_m77v-vfoEvBsA5V0IHpp7hGBxOCuxsWI4q8SOH7DKxF_3kuY27aOON4PD9d0_g-mAQVrjzoAXQRmwCrTxoKLQzjzi-gngFfLR |
| CitedBy_id | crossref_primary_10_1016_j_plefa_2020_102234 crossref_primary_10_14814_phy2_14721 crossref_primary_10_3389_fnut_2022_919357 crossref_primary_10_1038_s41598_023_45870_1 crossref_primary_10_1016_j_heliyon_2024_e35477 crossref_primary_10_1126_science_abj8894 crossref_primary_10_1177_20406223231156826 crossref_primary_10_1016_j_tranon_2021_101207 crossref_primary_10_1038_s41598_024_73672_6 crossref_primary_10_3389_fnut_2023_1237086 |
| Cites_doi | 10.1194/jlr.P023176 10.1016/j.metabol.2016.01.011 10.1194/jlr.M059113 10.1194/jlr.M300299-JLR200 10.1093/clinchem/42.5.732 10.1038/srep46658 10.1139/o03-078 10.1016/j.jacl.2015.06.012 10.1016/j.diabet.2007.02.004 10.3945/ajcn.112.043117 10.1371/journal.pgen.1002193 10.1016/j.jacl.2016.09.013 10.1016/S0006-291X(02)00666-6 10.1097/MOL.0b013e32834d2dc5 10.1038/nutd.2015.30 10.1139/apnm-2016-0043 10.1371/journal.pone.0147894 10.1016/S0022-2275(20)30473-9 10.3945/ajcn.117.152702 10.1016/j.febslet.2006.03.068 10.1194/jlr.P064170 10.1073/pnas.0707460104 10.1002/sim.1296 10.1007/s00125-005-0125-z 10.1016/j.celrep.2015.09.054 10.1159/000368325 10.1194/jlr.P032276 10.1038/sj.ijo.0803552 10.1007/s00592-014-0587-x 10.1152/ajpheart.01275.2010 10.1017/S0029665107005472 10.1016/j.febslet.2008.05.029 10.2337/diacare.26.5.1395 10.2337/db09-1568 10.3177/jnsv.55.400 10.1111/jhn.12272 10.1017/S0007114512005934 10.1146/annurev.immunol.021908.132612 10.1016/j.immuni.2013.05.015 10.1152/ajpendo.00398.2003 10.1007/s00125-006-0259-7 10.1373/clinchem.2009.136994 10.1007/s11033-010-0160-9 10.1016/S2213-8587(14)70146-9 10.3389/fphys.2011.00112 10.1186/1476-511X-8-37 10.1371/journal.pone.0010100 10.3389/fgene.2017.00021 10.1093/ajcn/nqy070 10.1161/ATVBAHA.112.300306 10.1002/oby.21753 10.1210/jc.2015-2693 10.3945/ajcn.114.102707 10.1016/j.bbrc.2014.07.010 10.1161/ATVBAHA.117.309660 10.1007/978-3-319-07320-0_7 10.1017/S0954422416000147 |
| ContentType | Journal Article |
| Copyright | 2019 American Society for Nutrition. 2018 American Society for Nutrition. 2019 Copyright American Institute of Nutrition Jan 2019 |
| Copyright_xml | – notice: 2019 American Society for Nutrition. – notice: 2018 American Society for Nutrition. 2019 – notice: Copyright American Institute of Nutrition Jan 2019 |
| DBID | 6I. AAFTH AAYXX CITATION CGR CUY CVF ECM EIF NPM K9. NAPCQ 7X8 7S9 L.6 5PM |
| DOI | 10.1093/jn/nxy238 |
| DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic AGRICOLA AGRICOLA - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Health & Medical Complete (Alumni) Nursing & Allied Health Premium MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AGRICOLA MEDLINE - Academic MEDLINE ProQuest Health & Medical Complete (Alumni) |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Diet & Clinical Nutrition |
| EISSN | 1541-6100 |
| EndPage | 67 |
| ExternalDocumentID | PMC6351138 30535058 10_1093_jn_nxy238 10.1093/jn/nxy238 S0022316622164382 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GrantInformation_xml | – fundername: Canadian Institute of Health Research grantid: MOP#93581; #123409 funderid: 10.13039/501100000024 – fundername: Fonds de recherche du Québec funderid: 10.13039/501100000156 – fundername: CIHR grantid: 123409 – fundername: CIHR grantid: MOP#93581 – fundername: ; ; ; – fundername: ; ; ; grantid: MOP#93581; #123409 |
| GroupedDBID | --- -ET -~X .55 .GJ 0R~ 18M 29L 2WC 34G 39C 3O- 4.4 48X 53G 5GY 5RE 5VS 6I. 85S A8Z AABJS AABMN AABZA AACZT AAFTH AAJQQ AAPGJ AAPQZ AAUQX AAVAP AAWDT AAWTL AAXUO AAYJJ ABBTP ABJNI ABPTD ABSAR ABSGY ABWST ACFRR ACGFO ACGOD ACIHN ACIMA ACKIV ACNCT ACUFI ACUTJ ADBBV ADEIU ADGZP ADRTK ADVEK AEAQA AENEX AETBJ AETEA AFDAS AFFNX AFFZL AFMIJ AFOFC AFRAH AFXAL AGINJ AGQXC AGUTN AHMBA AHPSJ AIKOY AIMBJ AJEEA ALEEW ALMA_UNASSIGNED_HOLDINGS AMRAJ AQDSO AQKUS ASMCH AZQFJ BAWUL BAYMD BCR BCRHZ BES BEYMZ BKOMP BLC BTRTY BYORX C1A CASEJ CDBKE DAKXR DIK DPPUQ DU5 E3Z EBS EIHJH EJD ENERS EX3 F5P F9R FDB FECEO FLUFQ FOEOM FOTVD FQBLK FRP G8K GAUVT GJXCC GX1 HF~ HZ~ IH2 K-O KBUDW KOP KQ8 KSI KSN L7B MBLQV MHKGH MV1 MVM NHB NHCRO NOMLY NOYVH NVLIB O9- OAUYM ODMLO OHT OJZSN OK1 OPAEJ OVD P-O P2P PEA PQQKQ PRG R0Z RHF RHI ROL ROX SV3 TAE TEORI TMA TN5 TNT TR2 TWZ UCJ UHB UKR UPT W2D W8F WH7 WHG WOQ WOW X7M XFK XOL XSW Y6R YBU YHG YKV YQJ YQT YSK ZGI ZHY ZXP ~KM 0SF ADUKH ADVLN AFRQD AITUG AKRWK H13 UIG AAGQS AALRI AAYWO AAYXX ABDPE ACVFH ADCNI ADMTO AEUPX AFJKZ AFPUW AGCQF AGKRT AIGII AKBMS AKYEP APXCP CITATION NU- YR5 CGR CUY CVF ECM EIF NPM Z5M EFKBS K9. NAPCQ 7X8 7S9 L.6 5PM |
| ID | FETCH-LOGICAL-c509t-b8c0fd45bcd0c71c7c136ca63f3da7cd9af07f61a414b8c0db50ba306354cd53 |
| ISSN | 0022-3166 1541-6100 |
| IngestDate | Thu Aug 21 13:42:12 EDT 2025 Fri Jul 11 09:54:46 EDT 2025 Fri Jul 11 16:10:30 EDT 2025 Fri Jul 25 23:04:28 EDT 2025 Wed Feb 19 02:25:09 EST 2025 Tue Jul 01 03:31:28 EDT 2025 Thu Apr 24 23:12:11 EDT 2025 Wed Sep 11 04:47:15 EDT 2024 Fri Feb 23 02:35:29 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | interleukin-1 IL-1Ra T2D IR FADS IS WAT postprandial fat metabolism apoB-lipoproteins GIIS δ-6-desaturase TRL GIR plasma phospholipid fatty acids D5D type 2 diabetes D6D overweight and obese adult men and postmenopausal women SNP ALA IVGTT atherogenic dyslipidemia insulin resistance δ-5-desaturase |
| Language | English |
| License | http://www.elsevier.com/open-access/userlicense/1.0 This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c509t-b8c0fd45bcd0c71c7c136ca63f3da7cd9af07f61a414b8c0db50ba306354cd53 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-4643-6462 |
| OpenAccessLink | https://dx.doi.org/10.1093/jn/nxy238 |
| PMID | 30535058 |
| PQID | 2176256407 |
| PQPubID | 34400 |
| PageCount | 11 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_6351138 proquest_miscellaneous_2352416045 proquest_miscellaneous_2155164766 proquest_journals_2176256407 pubmed_primary_30535058 crossref_primary_10_1093_jn_nxy238 crossref_citationtrail_10_1093_jn_nxy238 oup_primary_10_1093_jn_nxy238 elsevier_sciencedirect_doi_10_1093_jn_nxy238 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2019-01-01 |
| PublicationDateYYYYMMDD | 2019-01-01 |
| PublicationDate_xml | – month: 01 year: 2019 text: 2019-01-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Bethesda |
| PublicationTitle | The Journal of nutrition |
| PublicationTitleAlternate | J Nutr |
| PublicationYear | 2019 |
| Publisher | Elsevier Inc Oxford University Press American Institute of Nutrition |
| Publisher_xml | – name: Elsevier Inc – name: Oxford University Press – name: American Institute of Nutrition |
| References | Wassef, Bissonnette, Saint-Pierre, Lamantia, Cyr, Chretien, Faraj (bib8) 2015; 9 Khan, Minihane, Talmud, Wright, Murphy, Williams, Griffin (bib46) 2002; 43 Kuniyasu, Hayashi, Nakayama (bib6) 2002; 295 D'Agostino, Vasan, Pencina, Wolf, Cobain, Massaro, Kannel (bib26) 2008; 117 Faraj, Lu, Cianflone (bib2) 2004; 82 Swisa, Glaser, Dor (bib1) 2017; 8 Lamantia, Bissonnette, Wassef, Cyr, Baass, Dufour, Rabasa-Lhoret, Faraj (bib7) 2017; 11 Gromovsky, Schugar, Brown, Helsley, Burrows, Ferguson, Zhang, Sansbury, Lee, Morton (bib54) 2018; 38 Gelinas, Thompson-Legault, Bouchard, Daneault, Mansour, Gillis, Charron, Gavino, Labarthe, Des Rosiers (bib32) 2011; 301 Schectman, Patsches, Sasse (bib29) 1996; 42 Vaittinen, Mannisto, Kakela, Agren, Tiainen, Schwab, Pihlajamaki (bib20) 2017; 25 Lemaitre, Tanaka, Tang, Manichaikul, Foy, Kabagambe, Nettleton, King, Weng, Bhattacharya (bib44) 2011; 7 Onat, Can, Hergenc, Yazici, Karabulut, Albayrak (bib12) 2007; 31 Lamantia, Sniderman, Faraj (bib16) 2016; 29 D'Archivio, Scazzocchio, Filesi, Vari, Maggiorella, Sernicola, Santangelo, Giovannini, Masella (bib5) 2008; 582 Sun, Wei, Li (bib47) 2011; 38 Bissonnette, Salem, Wassef, Saint-Pierre, Tardif, Baass, Dufour, Faraj (bib3) 2013; 54 Weitkunat, Schumann, Nickel, Hornemann, Petzke, Schulze, Pfeiffer, Klaus (bib60) 2017; 105 Roke, Jannas-Vela, Spriet, Mutch (bib52) 2016; 41 Wassef, Salem, Bissonnette, Baass, Dufour, Davignon, Faraj (bib28) 2012; 32 Pan, Maitin, Parathath, Andreo, Lin, St Germain, Yao, Maxfield, Williams, Fisher (bib49) 2008; 105 Turcot, Brunet, Daneault, Tardif, Des Rosiers, Lettre (bib31) 2015; 28 Warensjo, Rosell, Hellenius, Vessby, De Faire, Riserus (bib42) 2009; 8 Vaittinen, Walle, Kuosmanen, Mannisto, Kakela, Agren, Schwab, Pihlajamaki (bib53) 2016; 57 Pocock, Assmann, Enos, Kasten (bib38) 2002; 21 Ley, Harris, Connelly, Mamakeesick, Gittelsohn, Wolever, Hegele, Zinman, Hanley (bib15) 2010; 56 Hwang, Ahn, Park, Park (bib13) 2014; 51 Adiels, Taskinen, Packard, Caslake, Soro-Paavonen, Westerbacka, Vehkavaara, Hakkinen, Olofsson, Yki-Jarvinen (bib50) 2006; 49 Thompson Legault, Strittmatter, Tardif, Sharma, Tremblay-Vaillancourt, Aubut, Boucher, Clish, Cyr, Daneault (bib30) 2015; 13 Gillingham, Harding, Refideout, Yurkova, Cunnane, Eck, Jones (bib45) 2013; 97 Bastard, Vandernotte, Faraj, Karelis, Messier, Malita, Garrel, Prud'homme, Rabasa-Lhoret (bib34) 2007; 33 Dinarello (bib55) 2009; 27 Sijben, Calder (bib56) 2007; 66 Chiappini, Coilly, Kadar, Gual, Tran, Desterke, Samuel, Duclos-Vallee, Touboul, Bertrand-Michel (bib51) 2017; 7 Walle, Takkunen, Mannisto, Vaittinen, Lankinen, Karja, Kakela, Agren, Tiainen, Schwab (bib41) 2016; 65 Al-Hilal, Alsaleh, Maniou, Lewis, Hall, Sanders, O'Dell (bib40) 2013; 54 Jacobs, Schiller, Jansen, Boeing, Schulze, Kroger (bib22) 2015; 102 Ingelsson, Langenberg, Hivert, Prokopenko, Lyssenko, Dupuis, Magi, Sharp, Jackson, Assimes (bib19) 2010; 59 Bissonnette, Saint-Pierre, Lamantia, Leroux, Provost, Cyr, Rabasa-Lhoret, Faraj (bib9) 2018; 108 Jensen, Rustad, Kolnes, Lai (bib35) 2011; 2 Forouhi, Koulman, Sharp, Imamura, Kroger, Schulze, Crowe, Huerta, Guevara, Beulens (bib58) 2014; 2 Kawashima, Sugawara, Okita, Akahane, Fukui, Hashiuchi, Kataoka, Tsukamoto (bib25) 2009; 55 Tosi, Sartori, Guarini, Olivieri, Martinelli (bib39) 2014; 824 Wolters, Schlenz, Bornhorst, Rise, Galli, Moreno, Pala, Siani, Veidebaum, Tornaritis (bib21) 2015; 100 Golley, Hendrie (bib59) 2014; 65 Vessby, Gustafsson, Tengblad, Berglund (bib43) 2013; 110 Salomaa, Havulinna, Saarela, Zeller, Jousilahti, Jula, Muenzel, Aromaa, Evans, Kuulasmaa (bib14) 2010; 5 Yan, Jiang, Spinetti, Tardivel, Castillo, Bourquin, Guarda, Tian, Tschopp, Zhou (bib57) 2013; 38 Bissonnette, Saint-Pierre, Lamantia, Cyr, Wassef, Faraj (bib10) 2015; 5 Faraj, Cianflone (bib37) 2004; 287 Zhao, Chen (bib48) 2014; 450 Tripathy, Wessman, Gullstrom, Tuomi, Groop (bib33) 2003; 26 Faraj, Sniderman, Cianflone (bib36) 2004; 45 Cyr, Wassef, Bissonnette, Lamantia, Davignon, Faraj (bib27) 2016; 57 Faraj, Messier, Bastard, Tardif, Godbout, Prud'homme, Rabasa-Lhoret (bib11) 2006; 49 Dupuis, Langenberg, Prokopenko, Saxena, Soranzo, Jackson, Wheeler, Glazer, Bouatia-Naji, Gloyn (bib18) 2010; 42 Do, Chung, Moon, Shin (bib24) 2011; 49 Kroger, Schulze (bib17) 2012; 23 Harris, Luo, Pottala, Margolis, Espeland, Robinson (bib23) 2016; 11 Masella, Vari, D'Archivio, Santangelo, Scazzocchio, Maggiorella, Sernicola, Titti, Sanchez, Di Mario (bib4) 2006; 580 Swisa (10.1093/jn/nxy238_bib1) 2017; 8 Warensjo (10.1093/jn/nxy238_bib42) 2009; 8 Thompson Legault (10.1093/jn/nxy238_bib30) 2015; 13 Hwang (10.1093/jn/nxy238_bib13) 2014; 51 Walle (10.1093/jn/nxy238_bib41) 2016; 65 Ingelsson (10.1093/jn/nxy238_bib19) 2010; 59 Onat (10.1093/jn/nxy238_bib12) 2007; 31 Faraj (10.1093/jn/nxy238_bib2) 2004; 82 Pocock (10.1093/jn/nxy238_bib38) 2002; 21 Zhao (10.1093/jn/nxy238_bib48) 2014; 450 Forouhi (10.1093/jn/nxy238_bib58) 2014; 2 D'Agostino (10.1093/jn/nxy238_bib26) 2008; 117 Roke (10.1093/jn/nxy238_bib52) 2016; 41 Jensen (10.1093/jn/nxy238_bib35) 2011; 2 Dinarello (10.1093/jn/nxy238_bib55) 2009; 27 Bissonnette (10.1093/jn/nxy238_bib3) 2013; 54 Kawashima (10.1093/jn/nxy238_bib25) 2009; 55 Sijben (10.1093/jn/nxy238_bib56) 2007; 66 Lamantia (10.1093/jn/nxy238_bib16) 2016; 29 Bastard (10.1093/jn/nxy238_bib34) 2007; 33 Masella (10.1093/jn/nxy238_bib4) 2006; 580 Ley (10.1093/jn/nxy238_bib15) 2010; 56 Tripathy (10.1093/jn/nxy238_bib33) 2003; 26 Harris (10.1093/jn/nxy238_bib23) 2016; 11 Bissonnette (10.1093/jn/nxy238_bib9) 2018; 108 Bissonnette (10.1093/jn/nxy238_bib10) 2015; 5 D'Archivio (10.1093/jn/nxy238_bib5) 2008; 582 Faraj (10.1093/jn/nxy238_bib11) 2006; 49 Wassef (10.1093/jn/nxy238_bib8) 2015; 9 Vaittinen (10.1093/jn/nxy238_bib20) 2017; 25 Faraj (10.1093/jn/nxy238_bib37) 2004; 287 Yan (10.1093/jn/nxy238_bib57) 2013; 38 Cyr (10.1093/jn/nxy238_bib27) 2016; 57 Lamantia (10.1093/jn/nxy238_bib7) 2017; 11 Turcot (10.1093/jn/nxy238_bib31) 2015; 28 Lemaitre (10.1093/jn/nxy238_bib44) 2011; 7 Vaittinen (10.1093/jn/nxy238_bib53) 2016; 57 Khan (10.1093/jn/nxy238_bib46) 2002; 43 Wolters (10.1093/jn/nxy238_bib21) 2015; 100 Al-Hilal (10.1093/jn/nxy238_bib40) 2013; 54 Vessby (10.1093/jn/nxy238_bib43) 2013; 110 Golley (10.1093/jn/nxy238_bib59) 2014; 65 Adiels (10.1093/jn/nxy238_bib50) 2006; 49 Chiappini (10.1093/jn/nxy238_bib51) 2017; 7 Weitkunat (10.1093/jn/nxy238_bib60) 2017; 105 Kuniyasu (10.1093/jn/nxy238_bib6) 2002; 295 Salomaa (10.1093/jn/nxy238_bib14) 2010; 5 Sun (10.1093/jn/nxy238_bib47) 2011; 38 Jacobs (10.1093/jn/nxy238_bib22) 2015; 102 Gromovsky (10.1093/jn/nxy238_bib54) 2018; 38 Schectman (10.1093/jn/nxy238_bib29) 1996; 42 Gillingham (10.1093/jn/nxy238_bib45) 2013; 97 Kroger (10.1093/jn/nxy238_bib17) 2012; 23 Tosi (10.1093/jn/nxy238_bib39) 2014; 824 Dupuis (10.1093/jn/nxy238_bib18) 2010; 42 Faraj (10.1093/jn/nxy238_bib36) 2004; 45 Do (10.1093/jn/nxy238_bib24) 2011; 49 Pan (10.1093/jn/nxy238_bib49) 2008; 105 Wassef (10.1093/jn/nxy238_bib28) 2012; 32 Gelinas (10.1093/jn/nxy238_bib32) 2011; 301 |
| References_xml | – volume: 56 year: 2010 ident: bib15 article-title: Association of apolipoprotein B with incident type 2 diabetes in an aboriginal Canadian population publication-title: Clin Chem – volume: 82 year: 2004 ident: bib2 article-title: Diabetes, lipids, and adipocyte secretagogues publication-title: Biochem Cell Biol – volume: 31 year: 2007 ident: bib12 article-title: Serum apolipoprotein B predicts dyslipidemia, metabolic syndrome and, in women, hypertension and diabetes, independent of markers of central obesity and inflammation publication-title: Int J Obes (Lond) – volume: 49 year: 2006 ident: bib50 article-title: Overproduction of large VLDL particles is driven by increased liver fat content in man publication-title: Diabetologia – volume: 8 start-page: 37 year: 2009 ident: bib42 article-title: Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance publication-title: Lipids Health Dis – volume: 100 year: 2015 ident: bib21 article-title: Desaturase activity is associated with weight status and metabolic risk markers in young children publication-title: J Clin Endocrinol Metab – volume: 65 year: 2014 ident: bib59 article-title: Evaluation of the relative concentration of serum fatty acids C14:0, C15:0 and C17:0 as markers of children's dairy fat intake publication-title: Ann Nutr Metab – volume: 2 start-page: 112 year: 2011 ident: bib35 article-title: The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise publication-title: Front Physiol – volume: 301 start-page: H813 year: 2011 end-page: 23 ident: bib32 article-title: Prolonged QT interval and lipid alterations beyond beta-oxidation in very long-chain acyl-CoA dehydrogenase null mouse hearts publication-title: Am J Physiol Heart Circ Physiol – volume: 5 start-page: e10100 year: 2010 ident: bib14 article-title: Thirty-one novel biomarkers as predictors for clinically incident diabetes publication-title: PLoS One – volume: 21 year: 2002 ident: bib38 article-title: Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: current practice and problems publication-title: Stat Med – volume: 7 start-page: 46658 year: 2017 ident: bib51 article-title: Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients publication-title: Sci Rep – volume: 26 year: 2003 ident: bib33 article-title: Importance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test: results with the Botnia clamp publication-title: Diabetes Care – volume: 9 year: 2015 ident: bib8 article-title: The apoB-to-PCSK9 ratio: a new index for metabolic risk in humans publication-title: J Clin Lipidol – volume: 41 year: 2016 ident: bib52 article-title: FADS2 genotype influences whole-body resting fat oxidation in young adult men publication-title: Appl Physiol Nutr Metab – volume: 295 year: 2002 ident: bib6 article-title: Adipocytes recognize and degrade oxidized low density lipoprotein through CD36 publication-title: Biochem Biophys Res Commun – volume: 45 year: 2004 ident: bib36 article-title: ASP enhances in situ lipoprotein lipase activity by increasing fatty acid trapping in adipocytes publication-title: J Lipid Res – volume: 27 year: 2009 ident: bib55 article-title: Immunological and inflammatory functions of the interleukin-1 family publication-title: Annu Rev Immunol – volume: 580 year: 2006 ident: bib4 article-title: Oxidised LDL modulate adipogenesis in 3T3-L1 preadipocytes by affecting the balance between cell proliferation and differentiation publication-title: FEBS Lett – volume: 28 year: 2015 ident: bib31 article-title: Validation of fatty acid intakes estimated by a food frequency questionnaire using erythrocyte fatty acid profiling in the Montreal Heart Institute Biobank publication-title: J Hum Nutr Diet – volume: 11 start-page: e0147894 year: 2016 ident: bib23 article-title: Red blood cell fatty acids and incident diabetes mellitus in the women's health initiative memory study publication-title: PLoS One – volume: 110 year: 2013 ident: bib43 article-title: Indices of fatty acid desaturase activity in healthy human subjects: effects of different types of dietary fat publication-title: Br J Nutr – volume: 11 start-page: 34 year: 2017 end-page: 45 ident: bib7 article-title: ApoB-lipoproteins and dysfunctional white adipose tissue: relation to risk factors for type 2 diabetes in humans publication-title: J Clin Lipidol – volume: 105 year: 2017 ident: bib60 article-title: Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate publication-title: Am J Clin Nutr – volume: 65 year: 2016 ident: bib41 article-title: Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity publication-title: Metabolism – volume: 49 year: 2011 ident: bib24 article-title: Relationship between the estimates of desaturase activities and cardiometabolic phenotypes in Koreans publication-title: J Clin Biochem Nutr – volume: 38 year: 2013 ident: bib57 article-title: Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation publication-title: Immunity – volume: 43 year: 2002 ident: bib46 article-title: Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype publication-title: J Lipid Res – volume: 108 start-page: 62 year: 2018 end-page: 76 ident: bib9 article-title: High plasma apolipoprotein B identifies obese subjects who best ameliorate white adipose tissue dysfunction and glucose-induced hyperinsulinemia after a hypocaloric diet publication-title: Am J Clin Nutr – volume: 5 start-page: e180 year: 2015 ident: bib10 article-title: Plasma IL-1Ra: linking hyperapoB to risk factors for type 2 diabetes independent of obesity in humans publication-title: Nutr Diabetes – volume: 450 year: 2014 ident: bib48 article-title: Eicosapentaenoic acid promotes thermogenic and fatty acid storage capacity in mouse subcutaneous adipocytes publication-title: Biochem Biophys Res Commun – volume: 54 year: 2013 ident: bib3 article-title: Low density lipoprotein delays clearance of triglycerefide-rich lipoprotein by human subcutaneous adipose tissue publication-title: J Lipid Res – volume: 7 start-page: e1002193 year: 2011 ident: bib44 article-title: Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium publication-title: PLoS Genet – volume: 582 year: 2008 ident: bib5 article-title: Oxidised LDL up-regulate CD36 expression by the Nrf2 pathway in 3T3-L1 preadipocytes publication-title: FEBS Lett – volume: 824 start-page: 61 year: 2014 end-page: 81 ident: bib39 article-title: Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease publication-title: Adv Exp Med Biol – volume: 23 start-page: 4 year: 2012 end-page: 10 ident: bib17 article-title: Recent insights into the relation of δ5 desaturase and δ6 desaturase activity to the development of type 2 diabetes publication-title: Curr Opin Lipidol – volume: 2 year: 2014 ident: bib58 article-title: Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study publication-title: Lancet Diabetes Endocrinol – volume: 57 year: 2016 ident: bib27 article-title: WAT apoC-I secretion: role in delayed chylomicron clearance in vivo and ex vivo in WAT in obese subjects publication-title: J Lipid Res – volume: 117 year: 2008 ident: bib26 article-title: General cardiovascular risk profile for use in primary care: the Framingham Heart Study publication-title: Circulation – volume: 59 year: 2010 ident: bib19 article-title: Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans publication-title: Diabetes – volume: 38 year: 2011 ident: bib47 article-title: DHA regulates lipogenesis and lipolysis genes in mice adipose and liver publication-title: Mol Biol Rep – volume: 66 year: 2007 ident: bib56 article-title: Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease publication-title: Proc Nutr Soc – volume: 38 year: 2018 ident: bib54 article-title: Δ-5 Fatty Acid Desaturase FADS1 impacts metabolic disease by balancing proinflammatory and proresolving lipid mediators publication-title: Arterioscler Thromb Vasc Biol – volume: 25 year: 2017 ident: bib20 article-title: Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity publication-title: Obesity (Silver Spring) – volume: 42 year: 1996 ident: bib29 article-title: Variability in cholesterol measurements: comparison of calculated and direct LDL cholesterol determinations publication-title: Clin Chem – volume: 97 year: 2013 ident: bib45 article-title: Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition publication-title: Am J Clin Nutr – volume: 287 start-page: E150 year: 2004 end-page: 9 ident: bib37 article-title: Differential regulation of fatty acid trapping in mouse adipose tissue and muscle by ASP publication-title: Am J Physiol Endocrinol Metab – volume: 54 year: 2013 ident: bib40 article-title: Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement publication-title: J Lipid Res – volume: 13 year: 2015 ident: bib30 article-title: A metabolic signature of mitochondrial dysfunction revealed through a monogenic form of Leigh syndrome publication-title: Cell Rep – volume: 42 year: 2010 ident: bib18 article-title: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk publication-title: Nat Genet – volume: 55 year: 2009 ident: bib25 article-title: Plasma fatty acid composition, estimated desaturase activities, and intakes of energy and nutrient in Japanese men with abdominal obesity or metabolic syndrome publication-title: J Nutr Sci Vitaminol (Tokyo) – volume: 102 year: 2015 ident: bib22 article-title: Evaluation of various biomarkers as potential mediators of the association between δ5 desaturase, δ6 desaturase, and stearoyl-CoA desaturase activity and incident type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition-Potsdam Study publication-title: Am J Clin Nutr – volume: 29 year: 2016 ident: bib16 article-title: Nutritional management of hyperapoB publication-title: Nutr Res Rev – volume: 33 year: 2007 ident: bib34 article-title: Relationship between the hyperinsulinemic-euglycaemic clamp and a new simple index assessing insulin sensitivity in overweight and obese postmenopausal women publication-title: Diabetes Metab – volume: 8 start-page: 21 year: 2017 ident: bib1 article-title: Metabolic stress and compromised identity of pancreatic beta cells publication-title: Front Genet – volume: 49 year: 2006 ident: bib11 article-title: Apolipoprotein B: a predictor of inflammatory status in postmenopausal overweight and obese women publication-title: Diabetologia – volume: 105 year: 2008 ident: bib49 article-title: Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control publication-title: Proc Natl Acad Sci U S A – volume: 51 year: 2014 ident: bib13 article-title: Apolipoprotein B and non-HDL cholesterol are more powerful predictors for incident type 2 diabetes than fasting glucose or glycated hemoglobin in subjects with normal glucose tolerance: a 3.3-year retrospective longitudinal study publication-title: Acta Diabetol – volume: 32 year: 2012 ident: bib28 article-title: White adipose tissue apolipoprotein C-I secretion in relation to delayed plasma clearance of dietary fat in humans publication-title: Arterioscler Thromb Vasc Biol – volume: 57 start-page: 56 year: 2016 end-page: 65 ident: bib53 article-title: FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue publication-title: J Lipid Res – volume: 54 year: 2013 ident: 10.1093/jn/nxy238_bib3 article-title: Low density lipoprotein delays clearance of triglycerefide-rich lipoprotein by human subcutaneous adipose tissue publication-title: J Lipid Res doi: 10.1194/jlr.P023176 – volume: 65 year: 2016 ident: 10.1093/jn/nxy238_bib41 article-title: Fatty acid metabolism is altered in non-alcoholic steatohepatitis independent of obesity publication-title: Metabolism doi: 10.1016/j.metabol.2016.01.011 – volume: 57 start-page: 56 year: 2016 ident: 10.1093/jn/nxy238_bib53 article-title: FADS2 genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue publication-title: J Lipid Res doi: 10.1194/jlr.M059113 – volume: 45 year: 2004 ident: 10.1093/jn/nxy238_bib36 article-title: ASP enhances in situ lipoprotein lipase activity by increasing fatty acid trapping in adipocytes publication-title: J Lipid Res doi: 10.1194/jlr.M300299-JLR200 – volume: 42 year: 1996 ident: 10.1093/jn/nxy238_bib29 article-title: Variability in cholesterol measurements: comparison of calculated and direct LDL cholesterol determinations publication-title: Clin Chem doi: 10.1093/clinchem/42.5.732 – volume: 7 start-page: 46658 year: 2017 ident: 10.1093/jn/nxy238_bib51 article-title: Metabolism dysregulation induces a specific lipid signature of nonalcoholic steatohepatitis in patients publication-title: Sci Rep doi: 10.1038/srep46658 – volume: 42 year: 2010 ident: 10.1093/jn/nxy238_bib18 article-title: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk publication-title: Nat Genet – volume: 82 year: 2004 ident: 10.1093/jn/nxy238_bib2 article-title: Diabetes, lipids, and adipocyte secretagogues publication-title: Biochem Cell Biol doi: 10.1139/o03-078 – volume: 9 year: 2015 ident: 10.1093/jn/nxy238_bib8 article-title: The apoB-to-PCSK9 ratio: a new index for metabolic risk in humans publication-title: J Clin Lipidol doi: 10.1016/j.jacl.2015.06.012 – volume: 33 year: 2007 ident: 10.1093/jn/nxy238_bib34 article-title: Relationship between the hyperinsulinemic-euglycaemic clamp and a new simple index assessing insulin sensitivity in overweight and obese postmenopausal women publication-title: Diabetes Metab doi: 10.1016/j.diabet.2007.02.004 – volume: 97 year: 2013 ident: 10.1093/jn/nxy238_bib45 article-title: Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition publication-title: Am J Clin Nutr doi: 10.3945/ajcn.112.043117 – volume: 7 start-page: e1002193 year: 2011 ident: 10.1093/jn/nxy238_bib44 article-title: Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium publication-title: PLoS Genet doi: 10.1371/journal.pgen.1002193 – volume: 11 start-page: 34 year: 2017 ident: 10.1093/jn/nxy238_bib7 article-title: ApoB-lipoproteins and dysfunctional white adipose tissue: relation to risk factors for type 2 diabetes in humans publication-title: J Clin Lipidol doi: 10.1016/j.jacl.2016.09.013 – volume: 295 year: 2002 ident: 10.1093/jn/nxy238_bib6 article-title: Adipocytes recognize and degrade oxidized low density lipoprotein through CD36 publication-title: Biochem Biophys Res Commun doi: 10.1016/S0006-291X(02)00666-6 – volume: 23 start-page: 4 year: 2012 ident: 10.1093/jn/nxy238_bib17 article-title: Recent insights into the relation of δ5 desaturase and δ6 desaturase activity to the development of type 2 diabetes publication-title: Curr Opin Lipidol doi: 10.1097/MOL.0b013e32834d2dc5 – volume: 5 start-page: e180 year: 2015 ident: 10.1093/jn/nxy238_bib10 article-title: Plasma IL-1Ra: linking hyperapoB to risk factors for type 2 diabetes independent of obesity in humans publication-title: Nutr Diabetes doi: 10.1038/nutd.2015.30 – volume: 41 year: 2016 ident: 10.1093/jn/nxy238_bib52 article-title: FADS2 genotype influences whole-body resting fat oxidation in young adult men publication-title: Appl Physiol Nutr Metab doi: 10.1139/apnm-2016-0043 – volume: 11 start-page: e0147894 year: 2016 ident: 10.1093/jn/nxy238_bib23 article-title: Red blood cell fatty acids and incident diabetes mellitus in the women's health initiative memory study publication-title: PLoS One doi: 10.1371/journal.pone.0147894 – volume: 43 year: 2002 ident: 10.1093/jn/nxy238_bib46 article-title: Dietary long-chain n-3 PUFAs increase LPL gene expression in adipose tissue of subjects with an atherogenic lipoprotein phenotype publication-title: J Lipid Res doi: 10.1016/S0022-2275(20)30473-9 – volume: 105 year: 2017 ident: 10.1093/jn/nxy238_bib60 article-title: Odd-chain fatty acids as a biomarker for dietary fiber intake: a novel pathway for endogenous production from propionate publication-title: Am J Clin Nutr doi: 10.3945/ajcn.117.152702 – volume: 580 year: 2006 ident: 10.1093/jn/nxy238_bib4 article-title: Oxidised LDL modulate adipogenesis in 3T3-L1 preadipocytes by affecting the balance between cell proliferation and differentiation publication-title: FEBS Lett doi: 10.1016/j.febslet.2006.03.068 – volume: 49 year: 2011 ident: 10.1093/jn/nxy238_bib24 article-title: Relationship between the estimates of desaturase activities and cardiometabolic phenotypes in Koreans publication-title: J Clin Biochem Nutr – volume: 57 year: 2016 ident: 10.1093/jn/nxy238_bib27 article-title: WAT apoC-I secretion: role in delayed chylomicron clearance in vivo and ex vivo in WAT in obese subjects publication-title: J Lipid Res doi: 10.1194/jlr.P064170 – volume: 105 year: 2008 ident: 10.1093/jn/nxy238_bib49 article-title: Presecretory oxidation, aggregation, and autophagic destruction of apoprotein-B: a pathway for late-stage quality control publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0707460104 – volume: 21 year: 2002 ident: 10.1093/jn/nxy238_bib38 article-title: Subgroup analysis, covariate adjustment and baseline comparisons in clinical trial reporting: current practice and problems publication-title: Stat Med doi: 10.1002/sim.1296 – volume: 49 year: 2006 ident: 10.1093/jn/nxy238_bib50 article-title: Overproduction of large VLDL particles is driven by increased liver fat content in man publication-title: Diabetologia doi: 10.1007/s00125-005-0125-z – volume: 13 year: 2015 ident: 10.1093/jn/nxy238_bib30 article-title: A metabolic signature of mitochondrial dysfunction revealed through a monogenic form of Leigh syndrome publication-title: Cell Rep doi: 10.1016/j.celrep.2015.09.054 – volume: 65 year: 2014 ident: 10.1093/jn/nxy238_bib59 article-title: Evaluation of the relative concentration of serum fatty acids C14:0, C15:0 and C17:0 as markers of children's dairy fat intake publication-title: Ann Nutr Metab doi: 10.1159/000368325 – volume: 54 year: 2013 ident: 10.1093/jn/nxy238_bib40 article-title: Genetic variation at the FADS1-FADS2 gene locus influences delta-5 desaturase activity and LC-PUFA proportions after fish oil supplement publication-title: J Lipid Res doi: 10.1194/jlr.P032276 – volume: 31 year: 2007 ident: 10.1093/jn/nxy238_bib12 article-title: Serum apolipoprotein B predicts dyslipidemia, metabolic syndrome and, in women, hypertension and diabetes, independent of markers of central obesity and inflammation publication-title: Int J Obes (Lond) doi: 10.1038/sj.ijo.0803552 – volume: 51 year: 2014 ident: 10.1093/jn/nxy238_bib13 article-title: Apolipoprotein B and non-HDL cholesterol are more powerful predictors for incident type 2 diabetes than fasting glucose or glycated hemoglobin in subjects with normal glucose tolerance: a 3.3-year retrospective longitudinal study publication-title: Acta Diabetol doi: 10.1007/s00592-014-0587-x – volume: 301 start-page: H813 year: 2011 ident: 10.1093/jn/nxy238_bib32 article-title: Prolonged QT interval and lipid alterations beyond beta-oxidation in very long-chain acyl-CoA dehydrogenase null mouse hearts publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.01275.2010 – volume: 66 year: 2007 ident: 10.1093/jn/nxy238_bib56 article-title: Differential immunomodulation with long-chain n-3 PUFA in health and chronic disease publication-title: Proc Nutr Soc doi: 10.1017/S0029665107005472 – volume: 582 year: 2008 ident: 10.1093/jn/nxy238_bib5 article-title: Oxidised LDL up-regulate CD36 expression by the Nrf2 pathway in 3T3-L1 preadipocytes publication-title: FEBS Lett doi: 10.1016/j.febslet.2008.05.029 – volume: 26 year: 2003 ident: 10.1093/jn/nxy238_bib33 article-title: Importance of obtaining independent measures of insulin secretion and insulin sensitivity during the same test: results with the Botnia clamp publication-title: Diabetes Care doi: 10.2337/diacare.26.5.1395 – volume: 59 year: 2010 ident: 10.1093/jn/nxy238_bib19 article-title: Detailed physiologic characterization reveals diverse mechanisms for novel genetic loci regulating glucose and insulin metabolism in humans publication-title: Diabetes doi: 10.2337/db09-1568 – volume: 55 year: 2009 ident: 10.1093/jn/nxy238_bib25 article-title: Plasma fatty acid composition, estimated desaturase activities, and intakes of energy and nutrient in Japanese men with abdominal obesity or metabolic syndrome publication-title: J Nutr Sci Vitaminol (Tokyo) doi: 10.3177/jnsv.55.400 – volume: 28 year: 2015 ident: 10.1093/jn/nxy238_bib31 article-title: Validation of fatty acid intakes estimated by a food frequency questionnaire using erythrocyte fatty acid profiling in the Montreal Heart Institute Biobank publication-title: J Hum Nutr Diet doi: 10.1111/jhn.12272 – volume: 110 year: 2013 ident: 10.1093/jn/nxy238_bib43 article-title: Indices of fatty acid desaturase activity in healthy human subjects: effects of different types of dietary fat publication-title: Br J Nutr doi: 10.1017/S0007114512005934 – volume: 117 year: 2008 ident: 10.1093/jn/nxy238_bib26 article-title: General cardiovascular risk profile for use in primary care: the Framingham Heart Study publication-title: Circulation – volume: 27 year: 2009 ident: 10.1093/jn/nxy238_bib55 article-title: Immunological and inflammatory functions of the interleukin-1 family publication-title: Annu Rev Immunol doi: 10.1146/annurev.immunol.021908.132612 – volume: 38 year: 2013 ident: 10.1093/jn/nxy238_bib57 article-title: Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation publication-title: Immunity doi: 10.1016/j.immuni.2013.05.015 – volume: 287 start-page: E150 year: 2004 ident: 10.1093/jn/nxy238_bib37 article-title: Differential regulation of fatty acid trapping in mouse adipose tissue and muscle by ASP publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00398.2003 – volume: 49 year: 2006 ident: 10.1093/jn/nxy238_bib11 article-title: Apolipoprotein B: a predictor of inflammatory status in postmenopausal overweight and obese women publication-title: Diabetologia doi: 10.1007/s00125-006-0259-7 – volume: 56 year: 2010 ident: 10.1093/jn/nxy238_bib15 article-title: Association of apolipoprotein B with incident type 2 diabetes in an aboriginal Canadian population publication-title: Clin Chem doi: 10.1373/clinchem.2009.136994 – volume: 38 year: 2011 ident: 10.1093/jn/nxy238_bib47 article-title: DHA regulates lipogenesis and lipolysis genes in mice adipose and liver publication-title: Mol Biol Rep doi: 10.1007/s11033-010-0160-9 – volume: 2 year: 2014 ident: 10.1093/jn/nxy238_bib58 article-title: Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study publication-title: Lancet Diabetes Endocrinol doi: 10.1016/S2213-8587(14)70146-9 – volume: 2 start-page: 112 year: 2011 ident: 10.1093/jn/nxy238_bib35 article-title: The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise publication-title: Front Physiol doi: 10.3389/fphys.2011.00112 – volume: 8 start-page: 37 year: 2009 ident: 10.1093/jn/nxy238_bib42 article-title: Associations between estimated fatty acid desaturase activities in serum lipids and adipose tissue in humans: links to obesity and insulin resistance publication-title: Lipids Health Dis doi: 10.1186/1476-511X-8-37 – volume: 5 start-page: e10100 year: 2010 ident: 10.1093/jn/nxy238_bib14 article-title: Thirty-one novel biomarkers as predictors for clinically incident diabetes publication-title: PLoS One doi: 10.1371/journal.pone.0010100 – volume: 8 start-page: 21 year: 2017 ident: 10.1093/jn/nxy238_bib1 article-title: Metabolic stress and compromised identity of pancreatic beta cells publication-title: Front Genet doi: 10.3389/fgene.2017.00021 – volume: 108 start-page: 62 year: 2018 ident: 10.1093/jn/nxy238_bib9 article-title: High plasma apolipoprotein B identifies obese subjects who best ameliorate white adipose tissue dysfunction and glucose-induced hyperinsulinemia after a hypocaloric diet publication-title: Am J Clin Nutr doi: 10.1093/ajcn/nqy070 – volume: 32 year: 2012 ident: 10.1093/jn/nxy238_bib28 article-title: White adipose tissue apolipoprotein C-I secretion in relation to delayed plasma clearance of dietary fat in humans publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.112.300306 – volume: 25 year: 2017 ident: 10.1093/jn/nxy238_bib20 article-title: Interorgan cross talk between fatty acid metabolism, tissue inflammation, and FADS2 genotype in humans with obesity publication-title: Obesity (Silver Spring) doi: 10.1002/oby.21753 – volume: 100 year: 2015 ident: 10.1093/jn/nxy238_bib21 article-title: Desaturase activity is associated with weight status and metabolic risk markers in young children publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2015-2693 – volume: 102 year: 2015 ident: 10.1093/jn/nxy238_bib22 publication-title: Am J Clin Nutr doi: 10.3945/ajcn.114.102707 – volume: 450 year: 2014 ident: 10.1093/jn/nxy238_bib48 article-title: Eicosapentaenoic acid promotes thermogenic and fatty acid storage capacity in mouse subcutaneous adipocytes publication-title: Biochem Biophys Res Commun doi: 10.1016/j.bbrc.2014.07.010 – volume: 38 year: 2018 ident: 10.1093/jn/nxy238_bib54 article-title: Δ-5 Fatty Acid Desaturase FADS1 impacts metabolic disease by balancing proinflammatory and proresolving lipid mediators publication-title: Arterioscler Thromb Vasc Biol doi: 10.1161/ATVBAHA.117.309660 – volume: 824 start-page: 61 year: 2014 ident: 10.1093/jn/nxy238_bib39 article-title: Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease publication-title: Adv Exp Med Biol doi: 10.1007/978-3-319-07320-0_7 – volume: 29 year: 2016 ident: 10.1093/jn/nxy238_bib16 article-title: Nutritional management of hyperapoB publication-title: Nutr Res Rev doi: 10.1017/S0954422416000147 |
| SSID | ssj0001498 |
| Score | 2.3538275 |
| Snippet | δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are... ABSTRACT Background δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs).... δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n-3 (ω-3) and n-6 (ω-6) polyunsaturated fatty acids (PUFAs). Their activities are... Background δ-5 and δ-6 desaturases (D5D and D6D) catalyze the endogenous conversion of n–3 (ω-3) and n–6 (ω-6) polyunsaturated fatty acids (PUFAs). Their... |
| SourceID | pubmedcentral proquest pubmed crossref oup elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 57 |
| SubjectTerms | Adipose tissue adiposity Adults antagonists apoB-lipoproteins Apolipoproteins B - blood atherogenic dyslipidemia Body mass index Body size Body weight Chylomicrons Clamps Data processing Delta-5 Fatty Acid Desaturase Desaturase Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - metabolism Eicosapentaenoic acid enzyme activity enzymes Fatty Acid Desaturases - genetics Fatty Acid Desaturases - metabolism Fatty acids Female Gene Expression Regulation, Enzymologic high fat foods Humans Insulin insulin resistance Insulin secretion Interleukin 1 lipid content Lipoproteins Male metabolic studies Middle Aged noninsulin-dependent diabetes mellitus Obesity omega-3 fatty acids Original Overweight Overweight - metabolism overweight and obese adult men and postmenopausal women phospholipid fatty acids Phospholipids Plasma plasma phospholipid fatty acids Polyunsaturated fatty acids Post-menopause postmenopause postprandial fat metabolism Risk analysis Risk Factors Substrates Triolein type 2 diabetes white adipose tissue women δ-5-desaturase δ-6-desaturase |
| Title | The Association of Polyunsaturated Fatty Acid δ-5-Desaturase Activity with Risk Factors for Type 2 Diabetes Is Dependent on Plasma ApoB-Lipoproteins in Overweight and Obese Adults |
| URI | https://dx.doi.org/10.1093/jn/nxy238 https://www.ncbi.nlm.nih.gov/pubmed/30535058 https://www.proquest.com/docview/2176256407 https://www.proquest.com/docview/2155164766 https://www.proquest.com/docview/2352416045 https://pubmed.ncbi.nlm.nih.gov/PMC6351138 |
| Volume | 149 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3bbtNAEF2FVEJ9QdwJtGhAFCGBqe-Xx7Rp1FIoVQmlb9ZmbQtHiRMlTtXyXf0OvokZ79q5NK2AFyvKjtdO5nh9Znf2DGNv_MjRY8ewtBjJsGaLJNL8wOCab8bo8JgbPqd5yC9H7v53-9OZc1arzSsET_PuR_Fr5b6S__Eqfod-pV2y_-DZqlP8Aj-jf_GIHsbjX_t47v9V-WyX02xCcp2cyGSb50izmyKN3m_t7m3t2JqjYaxZtJMmiVDVI4r52BPKM2-rCjyUf9iRE7StcoL2YIIDlKyam9MywzFy7wFHKjvc0T6no2Gh-pDK3PSvRco1xf7FAgVVIKD6z9O-1I4qGfFsb1pfJpWo6gBVphAfoPNlSu8p78uF_XE6SwZA5FCyTi7r_H1LB7Nzj8fDc7Wp5RR_Jp-lELTicz69UJuVVGdq7oO2W1VzH7Ear20Do19dXxjQpQjqAnLl8Cy1sK-9NaSiVo_ei9nFpSnlZubwMxoUALJIC0eXSvNLIt1l0x22ZmK8YtbZWvPw5MdhRQrwnvxS2CqwtnvZtrzSOrtbnnsTM1rYeDkX_yyn8c7xos59dk-5DpoSnQ9YLc4eskYrjXN4C0p1tg9HpVsfsSv0OMyhFoYJLKEWCtQCoRZ-Xy0gFkrEAiEWCLGgEAuIWCDEggklYuFgAhViAS8mEQvXEAtpBjPEAiIWCsSCROxj1mnvdXb3NVU7RBNIgXOt6ws9iWynKyJdeIbwhGG5grtWYkXcE1HAE91LXIPbhk22UdfRuxzjZ8uxReRYT1g9G2bxMwbcTmxXiCByg8BOvChwPeTwBhHtKHZMr8HelW4LhdLVp_Iu_VDmd1hhLwulsxvsdWU6kmIyq4w-lL4PFQuW7DZEuK4y30R83NbdRomcUA1dk9A0kAM5tIbfYK-qZnyx0GohPozDKdnQGrrtue4tNhi-YUSHYWGDPZVgrO6khHWDeQswrQxI2H6xJUt_FgL3LmU3WP7zG_t8wdZnw8EGq-fjabyJwUHefakevD-CuRtg |
| linkProvider | Library Specific Holdings |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+Association+of+Polyunsaturated+Fatty+Acid+%CE%B4-5-Desaturase+Activity+with+Risk+Factors+for+Type+2+Diabetes+Is+Dependent+on+Plasma+ApoB-Lipoproteins+in+Overweight+and+Obese+Adults&rft.jtitle=The+Journal+of+nutrition&rft.au=Lamantia%2C+Val%C3%A9rie&rft.au=Bissonnette%2C+Simon&rft.au=Provost%2C+Viviane&rft.au=Devaux%2C+Marie&rft.date=2019-01-01&rft.eissn=1541-6100&rft.volume=149&rft.issue=1&rft.spage=57&rft_id=info:doi/10.1093%2Fjn%2Fnxy238&rft_id=info%3Apmid%2F30535058&rft.externalDocID=30535058 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0022-3166&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0022-3166&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0022-3166&client=summon |