Mechanisms and modulation of microvesicle uptake in a model of alveolar cell communication

• Published in: The Journal of biological chemistry Vol. 292; no. 51; pp. 20897 - 20910
• Main Authors: Schneider, Daniel J., Speth, Jennifer M., Penke, Loka R., Wettlaufer, Scott H., Swanson, Joel A., Peters-Golden, Marc
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 22.12.2017; American Society for Biochemistry and Molecular Biology
• Subjects: actin; Actins - metabolism; Acute Lung Injury - physiopathology; albumin; alveolar; Alveolar Epithelial Cells - physiology; Animals; Cell Biology; Cell Communication - physiology; Cell Line; Cell-Derived Microparticles - physiology; Dynamins - metabolism; Endocytosis; epithelial; extracellular vesicles; Female; Ligands; macrophage; Macrophages, Alveolar - physiology; macropinocytosis; Models, Biological; Nicotiana - toxicity; oxidation; Oxidation-Reduction; Rats; Rats, Wistar; Receptors, Cell Surface - metabolism; Signal Transduction; Smoke - adverse effects; actin; extracellular vesicles; macropinocytosis; albumin; oxidation; endocytosis; macrophage; epithelial; alveolar

Extracellular vesicles, including exosomes and shed microvesicles (MVs), can be internalized by recipient cells to modulate function. Although the mechanism by which extracellular vesicles are internalized is incompletely characterized, it is generally considered to involve endocytosis and an initia...