Genome-wide CRISPR screen reveals CLPTM1L as a lipid scramblase required for efficient glycosylphosphatidylinositol biosynthesis - Wang, Yicheng; Menon, Anant K.; Maki, Yuta; Liu, Yi-Shi; Iwasaki, Yugo; Fujita, Morihisa; Guerrero, Paula A.; Silva, Daniel Varó’n; Seeberger, Peter H.; Murakami, Yoshiko; Kinoshita, Taroh (Proceedings of the National Academy of Sciences - PNAS, 2022)
Keywords: Biological Sciences; Biosynthesis; Cell surface; Cleft lip/palate; Clustered Regularly Interspaced Short Palindromic Repeats; CRISPR; Cytosol; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Genomes; Glycolipids; Glycosylphosphatidylinositol; Glycosylphosphatidylinositols - metabolism; Lipids; Lipogenesis; Membrane proteins; Membrane Proteins - genetics; Membrane Proteins - metabolism; Membranes; Phosphatidylinositol; Phospholipids; Proteins; Translocation; CLPTM1L; glycosylphosphatidylinositol; scramblase; endoplasmic reticulum; glycobiology