MTAP immunohistochemistry is an accurate and reproducible surrogate for CDKN2A fluorescence in situ hybridization in diagnosis of malignant pleural mesothelioma

• Published in: Modern pathology Vol. 33; no. 2; pp. 245 - 254
• Main Authors: Chapel, David B., Schulte, Jefree J., Berg, Kyra, Churg, Andrew, Dacic, Sanja, Fitzpatrick, Carrie, Galateau-Salle, Francoise, Hiroshima, Kenzo, Krausz, Thomas, Le Stang, Nolwenn, McGregor, Stephanie, Nabeshima, Kazuki, Husain, Aliya N.
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.02.2020; Elsevier Limited
• Subjects: 13/51; 38/32; 631/67/1641; 692/53/2421; 692/699/67/1641; Biomarkers, Tumor - analysis; Biomarkers, Tumor - genetics; Copy number; Cyclin-Dependent Kinase Inhibitor p16 - genetics; Diagnosis; Fluorescence in situ hybridization; France; Gene deletion; Humans; Hybridization; Immunohistochemistry; In Situ Hybridization, Fluorescence; Laboratories; Laboratory Medicine; Medical diagnosis; Medicine; Medicine & Public Health; Mesothelioma; Mesothelioma, Malignant - enzymology; Mesothelioma, Malignant - genetics; Mesothelioma, Malignant - pathology; North America; Observer Variation; Pathology; Pleural Neoplasms - enzymology; Pleural Neoplasms - genetics; Pleural Neoplasms - pathology; Predictive Value of Tests; Purine-Nucleoside Phosphorylase - analysis; Reproducibility of Results; Tokyo; France; Tokyo; North America

Ancillary studies facilitate accurate diagnosis of morphologically challenging mesothelial proliferations. The current diagnostic algorithm proceeds from BAP1 immunohistochemistry to CDKN2A fluorescence in situ hybridization. While MTAP immunohistochemistry has recently shown promise as a surrogate...