Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 6; pp. 3326 - 3336
• Main Authors: Dudek, Katarzyna A., Dion-Albert, Laurence, Lebel, Manon, LeClairc, Katherine, Labrecque, Simon, Tuck, Ellen, Perez, Carmen Ferrer, Golden, Sam A., Tamminga, Carol, Turecki, Gustavo, Mechawar, Naguib, Russo, Scott J., Menard, Caroline
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 11.02.2020
• Subjects: Adaptation; Animals; Antidepressants; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Autopsy; Biological Sciences; Blood; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain; Claudin-5 - metabolism; Cytokines; Depression - drug therapy; Depression - metabolism; Depressive Disorder, Major - metabolism; Disease Models, Animal; Endothelial cells; Endothelium; Epigenesis, Genetic - drug effects; Epigenesis, Genetic - physiology; FOXO1 protein; Histone Deacetylase 1 - metabolism; Humans; Inflammation; Inflammation - metabolism; Male; Mental depression; Mice; Mice, Inbred C57BL; Mood; NF-κB protein; Nucleus accumbens; Nucleus Accumbens - metabolism; Pathogenesis; Resilience; Signal Transduction - drug effects; Signal Transduction - physiology; Social interactions; Stress; Stress, Psychological - metabolism; Therapeutic applications; Tumor necrosis factor-α; epigenetic; inflammation; vascular; mood disorders; antidepressant

Preclinical and clinical studies suggest that inflammation and vascular dysfunction contribute to the pathogenesis of major depressive disorder (MDD). Chronic social stress alters blood–brain barrier (BBB) integrity through loss of tight junction protein claudin-5 (cldn5) in male mice, promoting pas...