Molecular adaptations of the blood–brain barrier promote stress resilience vs. depression - Dudek, Katarzyna A.; Dion-Albert, Laurence; Lebel, Manon; LeClairc, Katherine; Labrecque, Simon; Tuck, Ellen; Perez, Carmen Ferrer; Golden, Sam A.; Tamminga, Carol; Turecki, Gustavo; Mechawar, Naguib; Russo, Scott J.; et al. (Proceedings of the National Academy of Sciences - PNAS, 2020)
Keywords: Adaptation; Animals; Antidepressants; Antidepressive Agents - pharmacology; Antidepressive Agents - therapeutic use; Autopsy; Biological Sciences; Blood; Blood-brain barrier; Blood-Brain Barrier - metabolism; Brain; Claudin-5 - metabolism; Cytokines; Depression - drug therapy; Depression - metabolism; Depressive Disorder, Major - metabolism; Disease Models, Animal; Endothelial cells; Endothelium; Epigenesis, Genetic - drug effects; Epigenesis, Genetic - physiology; FOXO1 protein; Histone Deacetylase 1 - metabolism; Humans; Inflammation; Inflammation - metabolism; Male; Mental depression; Mice; Mice, Inbred C57BL; Mood; NF-κB protein; Nucleus accumbens; Nucleus Accumbens - metabolism; Pathogenesis; Resilience; Signal Transduction - drug effects; Signal Transduction - physiology; Social interactions; Stress; Stress, Psychological - metabolism; Therapeutic applications; Tumor necrosis factor-α; epigenetic; inflammation; vascular; mood disorders; antidepressant