Transmembrane Peptides Influence the Affinity of Sterols for Phospholipid Bilayers

• Published in: Biophysical journal Vol. 99; no. 2; pp. 526 - 533
• Main Authors: Nyström, Joel H., Lönnfors, Max, Nyholm, Thomas K.M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.07.2010; Biophysical Society; The Biophysical Society
• Subjects: Affinity; Anisotropy; beta-Cyclodextrins - pharmacology; Biophysics; Cellular biology; Cholestenes - metabolism; Cholesterol; Dimyristoylphosphatidylcholine - chemistry; Diphenylhexatriene - chemistry; Eukaryotes; Lipid Bilayers - metabolism; Lipids; Membrane; Membranes; Partitioning; Peptides; Peptides - pharmacology; Phosphatidylcholines - chemistry; Phospholipids; Phospholipids - chemistry; Plasma; Proteins; Sterols; DTPC; POPC; mβCD; CTL; DLPC; PSM; DMPC; LUV; DPH; KX

Cholesterol is distributed unevenly between different cellular membrane compartments, and the cholesterol content increases from the inner bilayers toward the plasma membrane. It has been suggested that this cholesterol gradient is important in the sorting of transmembrane proteins. Cholesterol has...