Striatal Dopamine Predicts Outcome-Specific Reversal Learning and Its Sensitivity to Dopaminergic Drug Administration

• Published in: The Journal of neuroscience Vol. 29; no. 5; pp. 1538 - 1543
• Main Authors: Cools, Roshan, Frank, Michael J, Gibbs, Sasha E, Miyakawa, Asako, Jagust, William, D'Esposito, Mark
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 04.02.2009; Society for Neuroscience
• Subjects: Bromocriptine - administration & dosage; Corpus Striatum - drug effects; Corpus Striatum - metabolism; Cross-Over Studies; Dopamine - metabolism; Dopamine - pharmacology; Dopamine Agonists - administration & dosage; Double-Blind Method; Female; Humans; Photic Stimulation; Positron-Emission Tomography; Predictive Value of Tests; Reversal Learning - drug effects; Reversal Learning - physiology; Reward; Young Adult

Individual variability in reward-based learning has been ascribed to quantitative variation in baseline levels of striatal dopamine. However, direct evidence for this pervasive hypothesis has hitherto been unavailable. We demonstrate that individual differences in reward-based reversal learning refl...