Brain-wide functional architecture remodeling by alcohol dependence and abstinence

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 117; no. 4; pp. 2149 - 2159
• Main Authors: Kimbrough, Adam, Lurie, Daniel J., Collazo, Andres, Kreifeldt, Max, Sidhu, Harpreet, Macedo, Giovana Camila, D’Esposito, Mark, Contet, Candice, George, Olivier
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 28.01.2020
• Series: PNAS Plus
• Subjects: Abuse; Alcohol use; Alcohols; Amygdala; Animal models; Architecture; Biological Sciences; Biomarkers; Brain; Brain architecture; Brain research; Dependence; Drinking behavior; Drug abuse; Drug dependence; Mesencephalon; Modularity; Modules; Neostriatum; Neuroimaging; PNAS Plus; Social problems; Target recognition; Thalamus; dependence; network analysis; Fos; iDISCO; graph theory

Alcohol abuse and alcohol dependence are key factors in the development of alcohol use disorder, which is a pervasive societal problem with substantial economic, medical, and psychiatric consequences. Although our understanding of the neurocircuitry that underlies alcohol use has improved, novel bra...