Enhancer priming by H3K4 methyltransferase MLL4 controls cell fate transition

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 113; no. 42; pp. 11871 - 11876
• Main Authors: Wang, Chaochen, Lee, Ji-Eun, Lai, Binbin, Macfarlan, Todd S., Xu, Shiliyang, Zhuang, Lenan, Liu, Chengyu, Peng, Weiqun, Ge, Kai
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 18.10.2016
• Subjects: Biological Sciences; Cellular biology; Gene expression; Genes; Leukemia; Methylation; Stem cells; Transcription factors; cell fate transition; p300; MLL4/KMT2D; enhancer; H3K4 methyltransferase

Transcriptional enhancers control cell-type–specific gene expression. Primed enhancers are marked by histone H3 lysine 4 (H3K4) mono/di-methylation (H3K4me1/2). Active enhancers are further marked by H3K27 acetylation (H3K27ac). Mixed-lineage leukemia 4 (MLL4/KMT2D) is a major enhancer H3K4me1/2 met...