Androgen-induced Long Noncoding RNA (lncRNA) SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells

• Published in: The Journal of biological chemistry Vol. 291; no. 34; pp. 17861 - 17880
• Main Authors: Misawa, Aya, Takayama, Ken-ichi, Urano, Tomohiko, Inoue, Satoshi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 19.08.2016; American Society for Biochemistry and Molecular Biology
• Subjects: androgen; androgen receptor; Androgens - pharmacology; apoptosis; Apoptosis - drug effects; Cell Line, Tumor; Epigenesis, Genetic - drug effects; Epigenesis, Genetic - genetics; Gene Expression Regulation, Neoplastic - drug effects; Gene Expression Regulation, Neoplastic - genetics; Gene Regulation; Humans; long noncoding RNA (lncRNA); Male; Neoplasm Proteins - biosynthesis; Neoplasm Proteins - genetics; prostate cancer; Prostatic Neoplasms, Castration-Resistant - genetics; Prostatic Neoplasms, Castration-Resistant - metabolism; Prostatic Neoplasms, Castration-Resistant - pathology; Receptors, Androgen - biosynthesis; Receptors, Androgen - genetics; RNA, Long Noncoding - biosynthesis; RNA, Long Noncoding - genetics; RNA, Neoplasm - biosynthesis; RNA, Neoplasm - genetics; Signal Transduction - drug effects; Signal Transduction - genetics; TNF-Related Apoptosis-Inducing Ligand - biosynthesis; TNF-Related Apoptosis-Inducing Ligand - genetics; Up-Regulation - drug effects; Up-Regulation - genetics; long noncoding RNA (lncRNA); apoptosis; androgen; prostate cancer; androgen receptor

Long noncoding RNAs (lncRNA) have been associated with the development of cancer. However, the interplay between lncRNAs and androgen receptor (AR) signaling in prostate cancer is still unclear. Here, we identified lncRNAs induced by androgen in AR-positive prostate cancer cells, where induction was...