Early Passage Dependence of Mesenchymal Stem Cell Mechanics Influences Cellular Invasion and Migration

• Published in: Annals of biomedical engineering Vol. 44; no. 7; pp. 2123 - 2131
• Main Authors: Spagnol, Stephen T., Lin, Wei-Chun, Booth, Elizabeth A., Ladoux, Benoit, Lazarus, Hillard M., Dahl, Kris Noel
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2016; Springer Nature B.V; Springer Verlag
• Subjects: Arrays; Biochemistry; Biochemistry, Molecular Biology; Biological and Medical Physics; Biological Physics; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Biophysics; Cell Culture Techniques - methods; Cell Movement; Cell Survival; Cells, Cultured; Classical Mechanics; Deformation; Formability; Human health and pathology; Humans; In vivo methods and tests; Injection; Life Sciences; Mechanical properties; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - metabolism; Migration; Optimization; Physics; Stem cells; Micropipette aspiration; Human mesenchymal stem cells; Mechanobiology; Cell mechanics

The cellular structures and mechanical properties of human mesenchymal stem cells (hMSCs) vary significantly during culture and with differentiation. Previously, studies to measure mechanics have provided divergent results using different quantitative parameters and mechanical models of deformation....