Targeting the PI3K/Akt signaling pathway in gastric carcinoma: A reality for personalized medicine?

• Published in: World journal of gastroenterology : WJG Vol. 21; no. 43; pp. 12261 - 12273
• Main Author: Singh, Shikha Satendra
• Format: Journal Article
• Language: English
• Published: United States Baishideng Publishing Group Inc 21.11.2015
• Subjects: Animals; Antineoplastic Agents - therapeutic use; Biomarkers, Tumor - antagonists & inhibitors; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; cancer;PI3K/Akt; Carcinoma - drug therapy; Carcinoma - enzymology; Carcinoma - genetics; Carcinoma - pathology; Drug Discovery - methods; Epidemiology;Gastric; Humans; Molecular Targeted Therapy; pathwa; Phosphatidylinositol 3-Kinase - antagonists & inhibitors; Phosphatidylinositol 3-Kinase - genetics; Phosphatidylinositol 3-Kinase - metabolism; Precision Medicine; Protein Kinase Inhibitors - therapeutic use; Proto-Oncogene Proteins c-akt - antagonists & inhibitors; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; Signal Transduction - drug effects; Stomach Neoplasms - drug therapy; Stomach Neoplasms - enzymology; Stomach Neoplasms - genetics; Stomach Neoplasms - pathology; Topic Highlight; TOR; TOR Serine-Threonine Kinases - antagonists & inhibitors; TOR Serine-Threonine Kinases - metabolism; Treatment Outcome; Targeted therapy; Epidemiology; Gastric cancer; PI3K/Akt/mTOR pathway; Predictive biomarkers

Frequent activation of phosphatidylinositol-3 kinases(PI3K)/Akt/m TOR signaling pathway in gastric cancer(GC) is gaining immense popularity with identification of mutations and/or amplifications of PIK3 CA gene or loss of function of PTEN,a tumor suppressor protein,to name a few; both playing a cruc...