Quantitative Proteomics Reveals Regulation of Karyopherin Subunit Alpha-2 (KPNA2) and Its Potential Novel Cargo Proteins in Nonsmall Cell Lung Cancer

• Published in: Molecular & cellular proteomics Vol. 11; no. 11; pp. 1105 - 1122
• Main Authors: Wang, Chun-I, Chien, Kun-Yi, Wang, Chih-Liang, Liu, Hao-Ping, Cheng, Chia-Chen, Chang, Yu-Sun, Yu, Jau-Song, Yu, Chia-Jung
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2012; The American Society for Biochemistry and Molecular Biology
• Subjects: alpha Karyopherins - chemistry; alpha Karyopherins - metabolism; Amino Acid Sequence; Carcinoma, Non-Small-Cell Lung - metabolism; Carcinoma, Non-Small-Cell Lung - pathology; Carrier Proteins - metabolism; Cell Line, Tumor; Cell Nucleus - metabolism; E2F1 Transcription Factor - metabolism; G2 Phase; Gene Knockdown Techniques; Humans; Isotope Labeling; Lung Neoplasms - metabolism; Lung Neoplasms - pathology; Mitosis; Models, Biological; Molecular Sequence Data; Neoplasm Proteins - metabolism; Protein Binding; Protein Transport; Proteome - metabolism; Proteomics - methods; Reproducibility of Results; RNA, Small Interfering - metabolism; Signal Transduction; Subcellular Fractions - metabolism

The process of nucleocytoplasmic shuttling is mediated by karyopherins. Dysregulated expression of karyopherins may trigger oncogenesis through aberrant distribution of cargo proteins. Karyopherin subunit alpha-2 (KPNA2) was previously identified as a potential biomarker for nonsmall cell lung cance...