A Single-Amino-Acid Polymorphism in Chikungunya Virus E2 Glycoprotein Influences Glycosaminoglycan Utilization

• Published in: Journal of Virology Vol. 88; no. 5; pp. 2385 - 2397
• Main Authors: Silva, Laurie A., Khomandiak, Solomiia, Ashbrook, Alison W., Weller, Romy, Heise, Mark T., Morrison, Thomas E., Dermody, Terence S.
• Format: Journal Article
• Language: English
• Published: United States American Society for Microbiology 01.03.2014
• Subjects: Alphavirus Infections - metabolism; Amino Acid Substitution; Animals; Arbovirus; Cercopithecus aethiops; Chikungunya Fever; Chikungunya virus; Chikungunya virus - genetics; Chikungunya virus - metabolism; Chikungunya virus - physiology; CHO Cells; Cricetinae; Cricetulus; Endosomes - metabolism; Endosomes - virology; Genotype; Glycosaminoglycans - metabolism; Glycosaminoglycans - pharmacology; Heparitin Sulfate - metabolism; Heparitin Sulfate - pharmacology; Humans; Hydrogen Bonding; Kinetics; Models, Molecular; Mutation; Polymorphism, Single Nucleotide; Protein Multimerization; Static Electricity; Vero Cells; Viral Envelope Proteins - chemistry; Viral Envelope Proteins - genetics; Virus Attachment - drug effects; Virus Internalization - drug effects; Virus Replication - drug effects; Virus-Cell Interactions; Asia; Africa

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